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Chunkit Fung, Sophie D. Fossa, Clair J. Beard and Lois B. Travis

relative survival rates of men with TC are both 95%. 2 , 3 This success results in not only an average gain of an additional 37 years of life 4 but also the emergence of considerable morbidities. These include second malignant neoplasms (SMNs), which have

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Chunkit Fung, Paul C. Dinh Jr, Sophie D. Fossa and Lois B. Travis

-related complications, including second malignant neoplasms (SMNs), cardiovascular disease (CVD), ototoxicity, neurotoxicity, nephrotoxicity, pulmonary toxicity, hypogonadism, infertility, anxiety, depression, cognitive impairment, and chronic cancer-related fatigue

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Andrea K. Ng and Lois B. Travis

Exposure to ionizing radiation has clearly been established as one of the risk factors for the development of breast cancer. Much data on the relationship between radiation exposures and subsequent breast cancer are derived from atomic bomb survivors and women who received medical exposures either for diagnostic or therapeutic purposes. Although these populations differ in background breast cancer risks and the dose, quality, and timing of radiation, consistent findings include an increased risk with younger age at exposure, long latency to breast cancer development, and increasing risk with increasing radiation dose. Although therapeutic radiation is rarely used to treat benign conditions, it remains an important and effective treatment modality for a wide range of cancers. Increased knowledge of radiation-related breast cancer and modifying influences plays an important role in guiding the initial treatment approach for young women and optimizing long-term follow-up care.

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Germ Cell Tumors Feldman Darren R. a c MD Schaffer Wendy L. b c MD, PhD Steingart Richard M. b c MD 4 2012 10 10 4 4 537 537 544 544 0100537 10.6004/jnccn.2012.0051 Second Malignant Neoplasms in Testicular Cancer Survivors Fung

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Debra L. Friedman and Louis S. Constine

reducing mortality and improving quality of life in long-term survivors of Hodgkin's disease: July 9-16, 2003, Bellagio, Italy . Eur J Haematol Suppl 2005 ; 66 : 68 – 76 . 3. Neglia JP Friedman DL Yasui Y . Second malignant neoplasms in five

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Mod C. Chandhanayingyong, Nicholas M. Bernthal, Piti Ungarreevittaya, Scott D. Nelson, Sant P. Chawla and Arun S. Singh

keratoses. and 35%, respectively. 7 – 10 Furthermore, patients with CS who have been diagnosed with one cancer have a 7-fold increased risk of developing subsequent cancers or second malignant neoplasms (SMNs). 11 A recent multicenter prospective

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Borislav Hristov, Ori Shokek and Deborah A. Frassica

. 62. Kleer CG Unni KK McLeod RA . Epithelioid hemangioendothelioma of bone . Am J Surg Pathol 1996 ; 20 : 1301 – 1311 . 63. Newton WA Jr Meadows AT Shimada H . Bone sarcomas as second malignant neoplasms following childhood cancer

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Eve Henry, Victor Villalobos, Lynn Million, Kristin C. Jensen, Robert West, Kristen Ganjoo, Alexandra Lebensohn, James M. Ford and Melinda L. Telli

SJ de Vathaire F Chrompret A . Radiation and genetic factors in the risk of second malignant neoplasm’s after a first cancer in childhood . Lancet 1997 ; 350 : 91 – 95 . 8 Li FP Fraumeni JF Jr Mulvihill JJ . A cancer family syndrome

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Eleni Efstathiou and Christopher J. Logothetis

– 612 . 13. Zagars GK Ballo MT Lee AK . Mortality after cure of testicular seminoma . J Clin Oncol 2004 ; 22 : 640 – 647 . 14. Travis LB Curtis RE Storm H . Risk of second malignant neoplasms among long-term survivors of

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Stefanie L. Thorsness, Azael Freites-Martinez, Michael A. Marchetti, Cristian Navarrete-Dechent, Mario E. Lacouture and Emily S. Tonorezos

, Scélo G , Pastore G , . Risk of second malignant neoplasms after childhood leukemia and lymphoma: an international study . J Natl Cancer Inst 2007 ; 99 : 790 – 800 . 10.1093/jnci/djk180 7. Meadows AT , Friedman DL , Neglia JP