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Matthew E. Nielsen, Bruce J. Trock, and Patrick C. Walsh

overall survival estimates in SWOG 8794: 74% for patients randomized to adjuvant RT versus 66% for those randomized to initial observation. 6 Figure 1 Actuarial prostate cancer–specific survival estimates at 10 years following salvage radiotherapy

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Ashley E. Ross

likelihood of developing metastasis after radical prostatectomy or salvage radiotherapy.” “Localized prostate cancer is characterized by extraordinary genomic complexity, with various copy number alterations—including deletions and amplifications

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Eli Rosenbaum, Alan Partin, and Mario A. Eisenberger

RD Haseman MK . Radioimmunoscintigraphy with In-111-labeled capromab pendetide predicts prostate cancer response to salvage radiotherapy after failed radical prostatectomy . J Clin Oncol 1998 ; 16 : 284 – 289 . 28 Thomas CT Bradshaw PT

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Andrew K. Lee and Christopher L. Amling

Radiotherapy After RP Approximately 30% of men treated with RP for clinically localized prostate cancer will experience biochemical recurrence within 10 years of surgery. Many of these patients will be candidates for salvage radiotherapy. Although most men

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Philip W. Kantoff and James L. Mohler

considered” in the presence of a diffusely positive surgical margin and positive surgical margin plus persistent PSA, Dr. Mohler advised. Regarding salvage radiotherapy, he pointed out that PSA elevation after radical prostatectomy does not necessarily lead

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Jeffrey M. Martin, Tianyu Li, Matthew E. Johnson, Colin T. Murphy, Alan G. Howald, Marc C. Smaldone, Alexander Kutikov, David Y.T. Chen, Rosalia Viterbo, Richard E. Greenberg, Robert G. Uzzo, and Eric M. Horwitz

. Postoperative radiotherapy after radical prostatectomy for high-risk prostate cancer: long-term results of a randomised controlled trial (EORTC trial 22911) . Lancet 2012 ; 380 : 2018 – 2027 . 8. King CR . Adjuvant versus salvage radiotherapy for

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James Mohler, Robert R. Bahnson, Barry Boston, J. Erik Busby, Anthony D'Amico, James A. Eastham, Charles A. Enke, Daniel George, Eric Mark Horwitz, Robert P. Huben, Philip Kantoff, Mark Kawachi, Michael Kuettel, Paul H. Lange, Gary MacVicar, Elizabeth R. Plimack, Julio M. Pow-Sang, Mack Roach III, Eric Rohren, Bruce J. Roth, Dennis C. Shrieve, Matthew R. Smith, Sandy Srinivas, Przemyslaw Twardowski, and Patrick C. Walsh

Kamat AM de Crevoisier R . Outcome of salvage radiotherapy for biochemical failure after radical prostatectomy with or without hormonal therapy . Int J Radiat Oncol Biol Phys 2005 ; 63 : 134 – 140 . 146. Lee AK D'Amico AV . Utility of

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James L. Mohler, Andrew J. Armstrong, Robert R. Bahnson, Anthony Victor D'Amico, Brian J. Davis, James A. Eastham, Charles A. Enke, Thomas A. Farrington, Celestia S. Higano, Eric M. Horwitz, Michael Hurwitz, Christopher J. Kane, Mark H. Kawachi, Michael Kuettel, Richard J. Lee, Joshua J. Meeks, David F. Penson, Elizabeth R. Plimack, Julio M. Pow-Sang, David Raben, Sylvia Richey, Mack Roach III, Stan Rosenfeld, Edward Schaeffer, Ted A. Skolarus, Eric J. Small, Guru Sonpavde, Sandy Srinivas, Seth A. Strope, Jonathan Tward, Dorothy A. Shead, and Deborah A. Freedman-Cass

independent of NCCN risk groups, that include likelihood of death with conservative management, likelihood of biochemical recurrence after surgery or radiotherapy, and likelihood of developing metastasis after surgery or salvage radiotherapy. 22 – 26 No

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Celestia S. Higano

. Early salvage radiotherapy following radical prostatectomy . Eur Urol , in press . 15. Higano C Shields A Wood N . Bone mineral density in patients with prostate cancer without bone metastases treated with intermittent androgen suppression

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Brandon A. Mahal, Ming-Hui Chen, Andrew A. Renshaw, Marian J. Loffredo, Philip W. Kantoff, and Anthony V. D'Amico

recurrent prostate cancer . N Engl J Med 2017 ; 376 : 417 – 428 . 11. Carrie C Hasbini A de Laroche G . Salvage radiotherapy with or without short-term hormone therapy for rising prostate-specific antigen concentration after radical