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Elizabeth R. Plimack and Gary R. Hudes

metastatic clear cell RCC Describe second-line management of patients with metastatic clear cell RCC I n the past 5 years, 6 new agents were approved for the treatment of renal cell carcinoma (RCC). These can be broadly categorized into 2 groups: vascular

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Gary R. Hudes, Michael A. Carducci, Toni K. Choueiri, Peg Esper, Eric Jonasch, Rashmi Kumar, Kim A. Margolin, M. Dror Michaelson, Robert J. Motzer, Roberto Pili, Susan Roethke and Sandy Srinivas

cases consist of renal cell carcinomas (RCCs), which are genetically and histologically distinct from cancers of the renal pelvis. An increased understanding of RCC biology coupled with new clinical trials data have resulted in the availability of

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Matthew P. Banegas, Linda C. Harlan, Bhupinder Mann and K. Robin Yabroff

In 2013, approximately 65,150 individuals in the United States were diagnosed with renal cell cancer (RCC). 1 Most (>60%) will have localized disease at diagnosis, although recurrences will develop in approximately 40% of patients initially

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Eric Jonasch and Robert J. Motzer

In the past 10 years, much has changed in the management of advanced renal cell carcinoma (RCC; Figure 1 ). The treatment of early-stage disease has become less morbid, with the widespread adoption of robotic surgical techniques and the increased

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Carlotta Palumbo, Francesco A. Mistretta, Sophie Knipper, Angela Pecoraro, Zhe Tian, Shahrokh F. Shariat, Fred Saad, Claudio Simeone, Alberto Briganti, Alessandro Antonelli and Pierre I. Karakiewicz

-up have a higher probability of remaining disease-free. 1 However, the magnitude of improved survival is difficult to estimate. Two studies 2 , 3 address cancer-specific CS in patients with nonmetastatic renal cell carcinoma (nmRCC): one is a population

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Pablo Maroto, Georgia Anguera, Juan Maria Roldan-Romero, Maria Apellániz-Ruiz, Ferran Algaba, Jacqueline Boonman, Mark Nellist, Cristina Montero-Conde, Alberto Cascón, Mercedes Robledo and Cristina Rodríguez-Antona

Chromophobe renal cell carcinoma (chRCC) is the third most frequent kidney cancer histologic subtype, accounting for approximately 5% of all RCC cases. At diagnosis, chRCC is generally confined to the kidney but can metastasize. At advanced stages

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Juan Francisco Rodríguez-Moreno, María Apellaniz-Ruiz, Juan María Roldan-Romero, Ignacio Durán, Luis Beltrán, Cristina Montero-Conde, Alberto Cascón, Mercedes Robledo, Jesus García-Donas and Cristina Rodríguez-Antona

Treatment of advanced renal cell carcinoma (RCC) has changed drastically in the past decade. The mTORC1 inhibitors, everolimus and temsirolimus (also known as rapalogs ), have been shown to be key drugs for use in first-line treatment 1 and

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Toni K. Choueiri

For the treatment of advanced renal cell cancer (RCC), 7 targeted agents have been approved in less than 8 years, which has greatly extended progression-free survival (PFS; Table 1 ). As even more targeted agents emerge from the pipeline, the

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Philip J. Saylor and M. Dror Michaelson

Petrylak D Thompson S . Cytotoxic chemotherapy for advanced renal cell carcinoma . Urol Clin North Am 1993 ; 20 : 303 – 321 . 3 Atkins MB Regan M McDermott D . Update on the role of interleukin 2 and other cytokines in the treatment of

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Saby George, Roberto Pili, Michael A. Carducci and Jenny J. Kim

inhibitors. Although the new agents result in a progression-free survival benefit, high-dose IL-2 remains the only agent with proven efficacy in producing durable complete and partial responses in patients with metastatic renal cell carcinoma (RCC