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Martha Wadleigh and Richard M. Stone

Desforges JF Schenkein DP . Granulocyte-macrophage colony stimulating factor (GM-CSF) priming in the treatment of elderly patients with acute myelogenous leukemia . Am J Hematol 1995 ; 49 : 48 – 55 . 25 Rowe JM Neuberg D Friedenberg W . A

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Deborah Cragun, Anne Weidner, Ann Tezak, Brenda Zuniga, Georgia L. Wiesner, and Tuya Pal

patient met with the GHP. To evaluate for a priming effect of the knowledge questions, the first 100 participants were randomly assigned to either group A or B using block randomization with block sizes between 1 and 5 individuals. 35 Participants in both

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David Y. Oh, Alan P. Venook, and Lawrence Fong

antibodies such as ipilimumab or tremelimumab would prevent CTLA4 on naïve T cells from competing with CD28 for B7 binding and delivery of inhibitory signals during priming, whereas ipilimumab may also lead to Treg depletion by ADCC (not shown). Other

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vaccinia-based vector for priming and a fowlpox-vector for subsequent boosting), each encoding transgenes for PSA in addition to 3 immune costimulatory molecules (B7.1, ICAM-1, and LFA-3). The authors and editorial office apologize for this error. A

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Jacqueline N. Poston and Pamela S. Becker

Acute Myeloid Leukemia The 2 key goals of myeloid growth factor (MGF) use in the management of acute myeloid leukemia (AML) have been (1) a theoretical benefit for “priming” to improve efficacy of chemotherapy, and (2) reduction of neutropenia

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Olga Frankfurt and Martin S. Tallman

gemtuzumab ozogamicin against acute myeloid leukemia cell lines and primary blast cells . Exp Hematol 2006 ; 34 : 54 – 65 . 31. Lowenberg B van Putten W Theobald M . Effect of priming with granulocyte colony-stimulating factor on the outcome of

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Mikkael A. Sekeres

Leukemia Group B . N Engl J Med 1994 ; 331 : 896 – 903 . 3. Rowe JM Neuberg D Friedenberg W . A phase 3 study of three induction regimens and of priming with GM-CSF in older adults with acute myeloid leukemia: a trial by the Eastern

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Cesar A. Santa-Maria and Rita Nanda

priming” tumors for immunotherapy. 5-azacitidine is a pyrimidine nucleoside analog that inhibits DNA methyltransferase, resulting in hypomethylation in a number of genes, and can thus regulate gene expression. In vitro studies in breast cancer cell lines

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Bhumsuk Keam, Jeong-Hoon Lee, Seock-Ah Im, and Jung-Hwan Yoon

alemtuzumab have induced profound and durable B- and T-cell depletion, 60 , 61 and B cells may modulate the priming cytotoxic T-cell response to HBV infection. 62 Table 2 Chemotherapeutic Agents Associated With Hepatitis B Virus Reactivation

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Harish N. Vasudevan and Sue S. Yom

and release of tumor antigens, priming immune activation to improve both local and distant control. 46 Such interplay can be divided into 2 scenarios of clinical benefit: increasing the magnitude of immunotherapy response in partial responders (with