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Todd L. Demmy, Lin Gu, Jack E. Burkhalter, Eric M. Toloza, Thomas A. D'Amico, Susan Sutherland, Xiaofei Wang, Laura Archer, Linda J. Veit, Leslie Kohman and the Cancer and Leukemia Group B

Approximately 100,000 new malignant pleural effusions (MPEs) occur annually in the United States, adversely affecting quality of life (QOL), often within months of death. 1 , 2 Optimal palliative management of these symptomatic patients is still

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David S. Ettinger, Wallace Akerley, Hossein Borghaei, Andrew Chang, Richard T. Cheney, Lucian R. Chirieac, Thomas A. D'Amico, Todd L. Demmy, Apar Kishor P. Ganti, Ramaswamy Govindan, Frederic W. Grannis, Leora Horn, Thierry M. Jahan, Mohammad Jahanzeb, Anne Kessinger, Ritsuko Komaki, Feng-Ming (Spring) Kong, Mark G. Kris, Lee M. Krug, Inga T. Lennes, Billy W. Loo, Renato Martins, Janis O'Malley, Raymond U. Osarogiagbon, Gregory A. Otterson, Jyoti D. Patel, Mary Pinder Schenck, Katherine M. Pisters, Karen Reckamp, Gregory J. Riely, Eric Rohren, Scott J. Swanson, Douglas E. Wood and Stephen C. Yang

form without the express written permission of NCCN®. Diagnosis Patients with suspected MPM often have symptoms (e.g., dyspnea and chest pain) and can also have pleural effusion, cough, chest wall mass, weight loss, fever, and sweating

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Frederic W. Grannis Jr

responsible in candidly discussing these weaknesses. The concern, however, is that those gathering evidence and writing guidelines on the subject of malignant pleural effusions at some later date, who will typically not have substantial clinical experience

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Paul J. Shami

. Thrombocytopenia was more common with dasatinib, whereas neutropenia occurred at equal frequency. Edema, nausea, vomiting, and rashes were more common with imatinib. In earlier studies, pleural effusions were seen in patients treated with dasatinib, particularly at

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Hema Sundar and Jerald Radich

taking antacids while on dasatinib due to potential drug-drug interactions and was also made aware of the common adverse events associated with dasatinib (eg, peripheral edema and pleural effusion). She was also asked to notify the doctor immediately if

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David S. Ettinger, Douglas E. Wood, Wallace Akerley, Lyudmila A. Bazhenova, Hossein Borghaei, David Ross Camidge, Richard T. Cheney, Lucian R. Chirieac, Thomas A. D'Amico, Thomas Dilling, Michael Dobelbower, Ramaswamy Govindan, Mark Hennon, Leora Horn, Thierry M. Jahan, Ritsuko Komaki, Rudy P. Lackner, Michael Lanuti, Rogerio Lilenbaum, Jules Lin, Billy W. Loo Jr, Renato Martins, Gregory A. Otterson, Jyoti D. Patel, Katherine M. Pisters, Karen Reckamp, Gregory J. Riely, Steven E. Schild, Theresa A. Shapiro, Neelesh Sharma, Scott J. Swanson, James Stevenson, Kurt Tauer, Stephen C. Yang, Kristina Gregory and Miranda Hughes

with suspected MPM often have dyspnea and chest pain; they may also have pleural effusion, fatigue, insomnia, cough, chest wall mass, loss of appetite, and weight loss. 14 – 16 Patients with MPM often have a high symptom burden; therefore, supportive

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10 10 8 8 969 969 974 974 0100969 10.6004/jnccn.2012.0101 Optimal Management of Malignant Pleural Effusions (Results of CALGB 30102) Demmy Todd L. a MD Gu Lin b MS Burkhalter Jack E. c PhD Toloza Eric M. d MD D'Amico Thomas

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-old woman presented with a dry, nonproductive cough that she had been experiencing for 2 to 3 months, intermittent bouts of severe shortness of breath, decreased appetite, and a 20-pound weight loss. Chest radiograph revealed mild bilateral pleural effusion

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Susan O'Brien, Ellin Berman, Joseph O. Moore, Javier Pinilla-Ibarz, Jerald P. Radich, Paul J. Shami, B. Douglas Smith, David S. Snyder, Hema M. Sundar, Moshe Talpaz and Meir Wetzler

frequency among patients receiving dasatinib and imatinib, whereas thrombocytopenia was more frequent with dasatinib ( Table 4 ). 20 Nonhematologic adverse events, except pleural effusions, were more frequent with imatinib. Pleural effusions, although

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Aby Z. Philip

pleural effusion. The patient continued to have moderate drainage from the peritoneal catheter and was started on albumin infusions multiple times weekly to correct hypoalbuminemia. Given her refractory disease and 17p deletion–positive status, we