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Emil Lou, Donna D'Souza, and Andrew C. Nelson

carcinoembryonic antigen (CEA) biomarker while on combination chemotherapy (FOLFIRI with bevacizumab), bevacizumab was discontinued in favor of initiating an EGFR inhibitor (panitumumab) while continuing the FOLFIRI backbone. This alteration to her treatment

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Al B. Benson III, J. Pablo Arnoletti, Tanios Bekaii-Saab, Emily Chan, Yi-Jen Chen, Michael A. Choti, Harry S. Cooper, Raza A. Dilawari, Paul F. Engstrom, Peter C. Enzinger, James W. Fleshman Jr., Charles S. Fuchs, Jean L. Grem, James A. Knol, Lucille A. Leong, Edward Lin, Kilian Salerno May, Mary F. Mulcahy, Kate Murphy, Eric Rohren, David P. Ryan, Leonard Saltz, Sunil Sharma, David Shibata, John M. Skibber, William Small Jr., Constantinos T. Sofocleous, Alan P. Venook, and Christopher Willett

bevacizumab, cetuximab, panitumumab, or irinotecan in adjuvant therapy for nonmetastatic disease outside the setting of a clinical trial. Adenocarcinomas of the small bowel or appendix, for which no NCCN Guidelines exist, may be treated with systemic

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Barbara Burtness, Milan Anadkat, Surendra Basti, Miranda Hughes, Mario E. Lacouture, Joan S. McClure, Patricia L. Myskowski, Jennifer Paul, Clifford S. Perlis, Leonard Saltz, and Sharon Spencer

cetuximab in head and neck cancer . N Engl J Med 2008 ; 359 : 1116 – 1127 . 11 Van Cutsem E Peeters M Siena S . Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with

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Zi-Xian Wang, Hao-Xiang Wu, Ming-Ming He, Ying-Nan Wang, Hui-Yan Luo, Pei-Rong Ding, Dan Xie, Gong Chen, Yu-Hong Li, Feng Wang, and Rui-Hua Xu

efficacy of chemotherapy + cetuximab (Cet) or panitumumab (Pani) versus chemotherapy ± bevacizumab (Bev) reported significant improvement in overall survival (OS), progression-free survival (PFS), and objective response rate (ORR) with chemotherapy + Cet

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Robin K. Kelley, Stephanie L. Van Bebber, Kathryn A. Phillips, and Alan P. Venook

panitumumab, the 2 EGFR-targeted monoclonal antibodies approved for use in colorectal cancer. 35 – 61 The strength of this association was later substantiated in retrospective analyses of patients treated in 6 large randomized studies. 62 – 67 Search results

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Robin K. Kelley, Grace Wang, and Alan P. Venook

EGFR-targeted therapy with cetuximab or panitumumab. 11 Patients whose tumors harbor certain mutations in the KRAS gene do not respond to cetuximab or panitumumab and should not be treated with either of these agents. 4 – 7 , 18 BRAF mutational

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Noman Ashraf, Nishi Kothari, and Richard Kim

mutations, and how these data may impact clinical decision-making Identify established predictive markers for cetuximab and panitumumab Discuss the clinical implications of data regarding potential new biomarkers for anti-EGFR therapy Colorectal

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Kristen Keon Ciombor and Tanios Bekaii-Saab

cetuximab and panitumumab (Tables 2 and 3 ); or multiple tyrosine kinases, such as regorafenib, 13 , 14 have also improved the efficacy of mCRC treatment in selected patients, both in combination with cytotoxic chemotherapy and as single agents in some

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Doreen A. Ezeife, Sunil Parimi, Ellen R. Cusano, Matthew K. Smith, Tony H. Truong, Soundouss Raissouni, Yongtao Lin, Jose G. Monzon, Haocheng Li, Vincent C. Tam, and Patricia A. Tang

panitumumab to combination chemotherapy yielded a 4-month OS improvement in the PRIME clinical trial. 5 However, this targeted therapy costs approximately $6,300 USD per month and is accompanied by cutaneous and other side effects. Value is a dynamic concept

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Paul F. Engstrom