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Barbara Burtness, Milan Anadkat, Surendra Basti, Miranda Hughes, Mario E. Lacouture, Joan S. McClure, Patricia L. Myskowski, Jennifer Paul, Clifford S. Perlis, Leonard Saltz, and Sharon Spencer

and ErbB3 in human ocular surface epithelia . Cornea 2001 ; 20 : 81 – 85 . 79 Basti S . Ocular toxicities of epidermal growth factor receptor inhibitors and their management . Cancer Nurs 2007 ; 30 ( 4 Suppl 1 ): S10 – 16 . 80

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John A. Thompson

iceberg. Ocular toxicity, a host of neurologic toxicities (eg, myositis, peripheral neuropathy, encephalitis, meningitis, transverse myelitis), and cardiac toxicities can all occur. Clinicians should be alert for these effects and consult the NCCN

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Barbara Burtness

this time. A Glimpse at Ocular Toxicity and EGFR Inhibitors Dr. Burtness briefly reviewed the effect of EGFR inhibitors on the eyes ( Figure 1 ). Among the reported ocular side effects are conjunctivitis, blepharitis, trichomegaly, corneal

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David P. Steensma

adverse events during deferasirox therapy, including hepatic failure, gastrointestinal hemorrhage, renal tubular acidosis, alopecia, agranulocytosis, otic or ocular toxicity, and anaphylaxis. 42 The frequency of these idiosyncratic serious events is as

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John A. Thompson, Bryan J. Schneider, Julie Brahmer, Stephanie Andrews, Philippe Armand, Shailender Bhatia, Lihua E. Budde, Luciano Costa, Marianne Davies, David Dunnington, Marc S. Ernstoff, Matthew Frigault, Brianna Hoffner, Christopher J. Hoimes, Mario Lacouture, Frederick Locke, Matthew Lunning, Nisha A. Mohindra, Jarushka Naidoo, Anthony J. Olszanski, Olalekan Oluwole, Sandip P. Patel, Sunil Reddy, Mabel Ryder, Bianca Santomasso, Scott Shofer, Jeffrey A. Sosman, Momen Wahidi, Yinghong Wang, Alyse Johnson-Chilla, and Jillian L. Scavone

surrounding the efficacy of corticosteroid therapy for treating acute interstitial nephritis linked to non-ICI–related causes. 188 , 189 Ocular Toxicity Ophthalmic irAEs are categorized by the affected area of the eye, into ocular inflammation (eg, uveitis

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Lindsey Robert Baden, Sankar Swaminathan, Michael Angarone, Gayle Blouin, Bernard C. Camins, Corey Casper, Brenda Cooper, Erik R. Dubberke, Ashley Morris Engemann, Alison G. Freifeld, John N. Greene, James I. Ito, Daniel R. Kaul, Mark E. Lustberg, Jose G. Montoya, Ken Rolston, Gowri Satyanarayana, Brahm Segal, Susan K. Seo, Shmuel Shoham, Randy Taplitz, Jeffrey Topal, John W. Wilson, Karin G. Hoffmann, and Courtney Smith

tolerated. 137 , 161 , 162 Cidofovir can be associated with substantial nephrotoxicity 151 , 152 ; although less frequent, ocular toxicity has been reported. 163 Acyclovir and valacyclovir have excellent safety profiles but are only weakly active against