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J. Matt McCrary, David Goldstein, Terry Trinh, Hannah C. Timmins, Tiffany Li, Jasmine Menant, Michael Friedlander, Craig R. Lewis, Mark Hertzberg, Siobhan O’Neill, Tracy King, Annmarie Bosco, Michelle Harrison and Susanna B. Park

treatment. Chemotherapy-induced peripheral neuropathy (CIPN) is a significant dose-limiting adverse effect of cancer treatment and is estimated to impact 68% of patients treated with neurotoxic chemotherapies, leading to functional disability and permanent

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Paul G. Richardson, Jacob P. Laubach, Robert L. Schlossman, Constantine Mitsiades and Kenneth Anderson

, 23 although neurotoxicity can also occur with short-term exposure. Bortezomib-Induced PN (BiPN) Bortezomib-induced PN is predominantly a small-fiber sensory neuropathy, characterized by distal symmetric loss of all modalities in the lower

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Presenter : Patrick A. Brown

-mediated neurotoxicity being the primary toxicities. According to Dr. Brown, the timing of these 2 toxicities is dictated and predicted by the timing of CAR T-cell expansion, or in the case of blinatumomab, endogenous T-cell expansion. “That expansion typically occurs

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Pilar de la Morena Barrio, María Ángeles Vicente Conesa, Enrique González-Billalabeitia, Edgar Urrego, Elisa García-Garre, Elena García-Martínez, Marta Zafra Poves, Vicente Vicente and Francisco Ayala de la Peña

neuropathy (PIPN) usually begins with paresthesia and numbness. 5 The neurotoxicity is cumulative and may result in functional impairment. Mild or moderate sensory symptoms usually improve after paclitaxel discontinuation, but severe neuropathy may be

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Chunkit Fung, Paul C. Dinh Jr, Sophie D. Fossa and Lois B. Travis

-related complications, including second malignant neoplasms (SMNs), cardiovascular disease (CVD), ototoxicity, neurotoxicity, nephrotoxicity, pulmonary toxicity, hypogonadism, infertility, anxiety, depression, cognitive impairment, and chronic cancer-related fatigue

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Matthias Holdhoff, Maciej M. Mrugala, Christian Grommes, Thomas J. Kaley, Lode J. Swinnen, Carlos Perez-Heydrich and Lakshmi Nayak

. Additionally, the significant neurotoxicity of WBRT at the doses administered for upfront therapy makes this modality unattractive for older patients. Therefore, WBRT is not recommended as first-line treatment in newly diagnosed patients. Role of Consolidation

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Eleni Efstathiou and Christopher J. Logothetis

; 104 : 521 – 524 . 73. Ta LE Espeset L Podratz J . Neurotoxicity of oxaliplatin and cisplatin for dorsal root ganglion neurons correlates with platinum-DNA binding . Neurotoxicology 2006 May 9; [Epub ahead of print] . 74

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Deirdre R. Pachman, Kathryn Ruddy, Lindsey R. Sangaralingham, Axel Grothey, Nilay D. Shah, Andreas S. Beutler, Joleen M. Hubbard and Charles L. Loprinzi

(CaMg), before and after oxaliplatin, has been the most studied approach to preventing oxaliplatin-induced neuropathy. This approach was based on a hypothesis that the sensory neurotoxicity of oxaliplatin was, at least partly, related to chelation of

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Crystal S. Denlinger and Andrea M. Barsevick

Edited by Kerrin G. Robinson

Oncol 2005 ; 23 : 6199 – 6206 . 42 Cersosimo RJ . Oxaliplatin-associated neuropathy: a review . Ann Pharmacother 2005 ; 39 : 128 – 135 . 43 Grothey A . Oxaliplatin-safety profile: neurotoxicity . Semin Oncol 2003 ; 30 : 5

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Michael D. Stubblefield, Harold J. Burstein, Allen W. Burton, Christian M. Custodio, Gary E. Deng, Maria Ho, Larry Junck, G. Stephen Morris, Judith A. Paice, Sudhakar Tummala and Jamie H. Von Roenn

induced neuropathy . Electromyogr Clin Neurophysiol 1999 ; 39 : 323 – 330 . 4 Park SB Krishnan AV Lin CS . Mechanisms underlying chemotherapy-induced neurotoxicity and the potential for neuroprotective strategies . Curr Med Chem 2008 ; 15