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Jeffrey Crawford, Jeffrey Allen, James Armitage, Douglas W. Blayney, Spero R. Cataland, Mark L. Heaney, Sally Htoy, Susan Hudock, Dwight D. Kloth, David J. Kuter, Gary H. Lyman, Brandon McMahon, David P. Steensma, Saroj Vadhan-Raj, Peter Westervelt and Michael Westmoreland

are lacking on the clinical benefits of G-CSFs and GM-CSFs. NCCN Clinical Practice Guidelines in Oncology : Myeloid Growth Factors Version Version 1.2011, 03-04-11 ©2011 National Comprehensive Cancer Network, Inc. All rights reserved. The NCCN

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Jeffrey Crawford, Pamela Sue Becker, James O. Armitage, Douglas W. Blayney, Julio Chavez, Peter Curtin, Shira Dinner, Thomas Fynan, Ivana Gojo, Elizabeth A. Griffiths, Shannon Hough, Dwight D. Kloth, David J. Kuter, Gary H. Lyman, Mary Mably, Sudipto Mukherjee, Shiven Patel, Lia E. Perez, Adam Poust, Raajit Rampal, Vivek Roy, Hope S. Rugo, Ayman A. Saad, Lee S. Schwartzberg, Sepideh Shayani, Mahsa Talbott, Saroj Vadhan-Raj, Sumithira Vasu, Martha Wadleigh, Peter Westervelt, Jennifer L. Burns and Lenora Pluchino

Myeloid growth factors (MGFs) are a class of biologic agents that regulate the proliferation, differentiation, survival, and activation of cells in the myeloid lineage. In patients with cancer receiving myelosuppressive chemotherapy, MGFs are primarily

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Jeffrey Crawford, James Armitage, Lodovico Balducci, Pamela Sue Becker, Douglas W. Blayney, Spero R. Cataland, Mark L. Heaney, Susan Hudock, Dwight D. Kloth, David J. Kuter, Gary H. Lyman, Brandon McMahon, Hope S. Rugo, Ayman A. Saad, Lee S. Schwartzberg, Sepideh Shayani, David P. Steensma, Mahsa Talbott, Saroj Vadhan-Raj, Peter Westervelt, Michael Westmoreland, Mary Dwyer and Maria Ho

, vitality, and mental health. 4 NCCN Clinical Practice Guidelines in Oncology : Myeloid Growth Factors, Version 2.2013 Version 2.2013, 08-02-13 ©2013 National Comprehensive Cancer Network, Inc. All rights reserved. The NCCN Guidelines#x000AE; and

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Jeffrey Crawford, James Armitage, Lodovico Balducci, Charles Bennett, Douglas W. Blayney, Spero R. Cataland, David C. Dale, George D. Demetri, Harry P. Erba, James Foran, Alison G. Freifeld, Marti Goemann, Mark L. Heaney, Sally Htoy, Susan Hudock, Dwight D. Kloth, David J. Kuter, Gary H. Lyman, Laura Boehnke Michaud, Sarah C. Miyata, Martin S. Tallman, Saroj Vadhan-Raj, Peter Westervelt and Michael K. Wong

the express written permission of the NCCN © 2009. Disclosures for the NCCN Myeloid Growth Factors Guidelines Panel At the beginning of each NCCN guidelines panel meeting, panel members disclosed any financial support they have received from

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David C. Dale

myeloid growth factor guidelines in patients receiving cancer chemotherapy . J Natl Compr Canc Netw 2007 ; 5 : 217 – 228 . 18 Gaberc-Porekar V Zore I Podobnik B Menart V . Obstacles and pitfalls in the PEGylation of therapeutic proteins

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Gary H. Lyman and David C. Dale

EORTC recommend myeloid growth factors be considered for patients undergoing chemotherapy who have a 20% or greater risk of febrile neutropenia. 3 – 5 G-CSF support is closely correlated with the delivery of systemic chemotherapy and, therefore, both

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Jacqueline N. Poston and Pamela S. Becker

Acute Myeloid Leukemia The 2 key goals of myeloid growth factor (MGF) use in the management of acute myeloid leukemia (AML) have been (1) a theoretical benefit for “priming” to improve efficacy of chemotherapy, and (2) reduction of neutropenia

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Jeffrey Crawford and George M. Rodgers

. At the NCCN 19th Annual Conference, Dr. Crawford and George M. Rodgers, MD, PhD, Professor of Medicine, Huntsman Cancer Institute at the University of Utah, discussed the appropriate use of myeloid growth factors (MGFs) to prevent neutropenia and the

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Gary H. Lyman and Jessica Malone Kleiner

the National Comprehensive Cancer Network on the use of the myeloid growth factors with cancer chemotherapy: a review of the evidence . J Natl Compr Canc Netw 2005 ; 3 : 557 – 571 . 4. Kuderer NM Dale D Crawford J . The morbidity

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Jeffrey Crawford

, the NCCN Guidelines Panel initially established the febrile neutropenia threshold for use of myeloid growth factors at 20%; this standard has now been adopted by virtually all other guidelines committees. Moreover, it was the NCCN Panel who stressed