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David G. Pfister, Kie-Kian Ang, David M. Brizel, Barbara Burtness, Anthony J. Cmelak, A. Dimitrios Colevas, Frank Dunphy, David W. Eisele, Jill Gilbert, Maura L. Gillison, Robert I. Haddad, Bruce H. Haughey, Wesley L. Hicks Jr., Ying J. Hitchcock, Merrill S. Kies, William M. Lydiatt, Ellie Maghami, Renato Martins, Thomas McCaffrey, Bharat B. Mittal, Harlan A. Pinto, John A. Ridge, Sandeep Samant, Giuseppe Sanguineti, David E. Schuller, Jatin P. Shah, Sharon Spencer, Andrea Trotti III, Randal S. Weber, Gregory Wolf and Frank Worden

Overview Mucosal melanoma (MM) is a rare, very aggressive noncutaneous melanoma that affects the upper aerodigestive tract, genitourinary tract, and anal/rectal region. 1 This portion of the NCCN Clinical Practice Guidelines in Oncology (NCCN

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Richard D. Carvajal, Sharon A. Spencer and William Lydiatt

Mucosal melanoma (MM) is an aggressive and clinically complex malignancy made more challenging by its relative rarity. Of the 68,130 cases of melanoma diagnosed in 2010 in the United States, only 0.8% to 1.8% of these arise from mucosal surfaces

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Thomas DO Perlis Clifford S. MD, MBe Shaha Ashok R. MD Tuli Malika MD Urist Marshall M. MD Wang Linda C. MD, JD Zic John A. MD 3 2012 10 10 3 3 312 312 318 318 0100312 10.6004/jnccn.2012.0032 Mucosal Melanoma of

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David G. Pfister, Sharon Spencer, David M. Brizel, Barbara Burtness, Paul M. Busse, Jimmy J. Caudell, Anthony J. Cmelak, A. Dimitrios Colevas, Frank Dunphy, David W. Eisele, Robert L. Foote, Jill Gilbert, Maura L. Gillison, Robert I. Haddad, Bruce H. Haughey, Wesley L. Hicks Jr, Ying J. Hitchcock, Antonio Jimeno, Merrill S. Kies, William M. Lydiatt, Ellie Maghami, Thomas McCaffrey, Loren K. Mell, Bharat B. Mittal, Harlan A. Pinto, John A. Ridge, Cristina P. Rodriguez, Sandeep Samant, Jatin P. Shah, Randal S. Weber, Gregory T. Wolf, Frank Worden, Sue S. Yom, Nicole McMillian and Miranda Hughes

– 45 Proton therapy has been used to treat oropharyngeal cancers, sinonasal malignancies, and mucosal melanomas, although the clinical data are best established for ocular melanomas and chordomas. 46 – 51 Single-institution outcome data have been

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Sarah T. Le, Pritesh S. Karia, Beverley J. Vollenhoven, Robert J. Besaw, Colleen M. Feltmate and Chrysalyne D. Schmults

and the American Cancer Society . Cancer 1998 ; 83 : 1664 – 1678 . 24. Lotem M Anteby S Peretz T . Mucosal melanoma of the female genital tract is a multifocal disorder . Gynecol Oncol 2003 ; 88 : 45 – 50 . 25. Mihajlovic M

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Daniel G. Coit, John A. Thompson, Alain Algazi, Robert Andtbacka, Christopher K. Bichakjian, William E. Carson III, Gregory A. Daniels, Dominick DiMaio, Marc Ernstoff, Ryan C. Fields, Martin D. Fleming, Rene Gonzalez, Valerie Guild, Allan C. Halpern, F. Stephen Hodi Jr, Richard W. Joseph, Julie R. Lange, Mary C. Martini, Miguel A. Materin, Anthony J. Olszanski, Merrick I. Ross, April K. Salama, Joseph Skitzki, Jeff Sosman, Susan M. Swetter, Kenneth K. Tanabe, Javier F. Torres-Roca, Vijay Trisal, Marshall M. Urist, Nicole McMillian and Anita Engh

NCCN Guidelines for Melanoma do not include recommendations for the diagnostic workup or treatment of early-stage mucosal or uveal melanoma. Guidelines for initial diagnostic workup and treatment of mucosal melanoma of the head and neck can be found in

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Shailender Bhatia and John A. Thompson

on the success of vemurafenib in BRAF -mutant melanoma, the biology of BRAF wild-type melanoma and noncutaneous melanoma types (such as ocular and mucosal melanoma) must be elucidated further. The development of brain metastases is a major cause of

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David G. Pfister, Sharon Spencer, David M. Brizel, Barbara Burtness, Paul M. Busse, Jimmy J. Caudell, Anthony J. Cmelak, A. Dimitrios Colevas, Frank Dunphy, David W. Eisele, Jill Gilbert, Maura L. Gillison, Robert I. Haddad, Bruce H. Haughey, Wesley L. Hicks Jr, Ying J. Hitchcock, Antonio Jimeno, Merrill S. Kies, William M. Lydiatt, Ellie Maghami, Renato Martins, Thomas McCaffrey, Loren K. Mell, Bharat B. Mittal, Harlan A. Pinto, John A. Ridge, Cristina P. Rodriguez, Sandeep Samant, David E. Schuller, Jatin P. Shah, Randal S. Weber, Gregory T. Wolf, Frank Worden, Sue S. Yom, Nicole R. McMillian and Miranda Hughes

, and mucosal melanoma. 1 , 2 The complete version of the NCCN Guidelines for H&N Cancers is available at NCCN.org . Updates to these guidelines for 2014 include revisions to “Principles of Radiation Therapy” for each site and “Principles of Surgery

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David G. Pfister, Kie-Kian Ang, David M. Brizel, Barbara A. Burtness, Anthony J. Cmelak, A. Dimitrios Colevas, Frank Dunphy, David W. Eisele, Jill Gilbert, Maura L. Gillison, Robert I. Haddad, Bruce H. Haughey, Wesley L. Hicks Jr., Ying J. Hitchcock, Merrill S. Kies, William M. Lydiatt, Ellie Maghami, Renato Martins, Thomas McCaffrey, Bharat B. Mittal, Harlan A. Pinto, John A. Ridge, Sandeep Samant, Giuseppe Sanguineti, David E. Schuller, Jatin P. Shah, Sharon Spencer, Andy Trotti III, Randal S. Weber, Gregory T. Wolf and Frank Worden

of H&N cancer (e.g., lip, larynx, paranasal sinus, salivary gland, mucosal melanoma, and occult primary cancer) are included in the complete version of the H&N guidelines available on the NCCN Web site ( www.NCCN.org ). A brief overview of the