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Jerald P. Radich, Andrew D. Zelenetz, Wing C. Chan, Carlo M. Croce, Myron S. Czuczman, Harry P. Erba, Sandra J. Horning, Jane Houldsworth, B. Douglas Smith, David S. Snyder, Hema M. Sundar, Meir Wetzler and Jane N. Winter

. Oncogenes and cancer . N Engl J Med 2008 ; 358 : 502 – 511 279 Cowland JB Hother C Gronbaek K . MicroRNAs and cancer . APMIS 2007 ; 115 : 1090 – 1106 280 Esquela-Kerscher A Slack FJ . Oncomirs—microRNAs with a role in cancer

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Jill Corre and Hervé Avet-Loiseau

clinical outcome. 34 MicroRNA are small noncoding RNA molecules that regulate multiple target genes through cleavage of targeted transcripts and inducing translational inhibition. The differential expression of several microRNAs has been described in

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Gauri R. Varadhachary

validated using independent blinded sets of tumor samples, in which the reference diagnosis is known, with an accuracy of 80% to 90%. 34 – 39 These genomic technologies that provide large-scale gene expression profiles based on mRNA or microRNA are

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receptor tyrosine kinase (RTK) expression using antibody array, the status of target RTK (VEGFR, c-KIT, PDGFR) expression by immunohistochemistry and assessment of pathway inhibition by Western blot Assess changes in protein-coding genes, microRNA

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Mark G. Frattini and Peter G. Maslak

Edited by Kerrin G. Robinson

. MicroRNA miR-181a correlates with morphological sub-class of acute myeloid leukaemia and the expression of its target genes in global genome-wide analysis . Leukemia 2007 ; 21 : 912 – 916 . 66. Dixon-McIver A East P Mein CA . Distinctive

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Wing C. Chan and James O. Armitage

class of small regulatory RNA called microRNA, intense research interest has been focused on this group of small noncoding RNAs. 47 – 49 Several studies have found that the pattern of expression of these microRNAs is related to the cell of origin of a

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Christine M. Coticchia, Jiang Yang and Marsha A. Moses

– 854 . 62. Garzon R Fabbri M Cimmino A . MicroRNA expression and function in cancer . Trends Mol Med 2006 ; 12 : 580 – 587 . 63. Lu J Getz G Miska EA . MicroRNA expression profiles classify human cancers . Nature 2005 ; 435

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David S. Ettinger, Charles R. Handorf, Mark Agulnik, Daniel W. Bowles, Justin M. Cates, Mihaela Cristea, Efrat Dotan, Keith D. Eaton, Panagiotis M. Fidias, David Gierada, G. Weldon Gilcrease, Kelly Godby, Renuka Iyer, Renato Lenzi, John Phay, Asif Rashid, Leonard Saltz, Richard B. Schwab, Lawrence N. Shulman, Jeffrey B. Smerage, Marvaretta M. Stevenson, Gauri R. Varadhachary, Jonathan S. Zager, Weining (Ken) Zhen, Mary Anne Bergman and Deborah A. Freedman-Cass

molecular profiling has recently generated some interest for its potential to identify the tissue of origin of CUPs. This assay is based on the presence of microRNAs (miRNAs), which are noncoding RNAs that regulate gene expression and show high tissue

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Kamel Izeradjene and Sunil R. Hingorani

clinical progress . Nat Rev Cancer 2005 ; 5 : 459 – 467 . 56. Croce CM Calin GA . miRNAs, cancer, and stem cell division . Cell 2005 ; 122 : 6 – 7 . 57. Esquela-Kerscher A Slack FJ . Oncomirs—microRNAs with a role in cancer

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of pralatrexate Whether response to pralatrexate can be predicted by microRNA expression profiling of the epithelial component of the tumor Contact: Nikhil I. Khushalani, MD • 716-845-3099 • nikhil