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David S. Ettinger, Wallace Akerley, Gerold Bepler, Matthew G. Blum, Andrew Chang, Richard T. Cheney, Lucian R. Chirieac, Thomas A. D'Amico, Todd L. Demmy, Ramaswamy Govindan, Frederic W. Grannis Jr., Thierry Jahan, David H. Johnson, Anne Kessinger, Ritsuko Komaki, Feng-Ming Kong, Mark G. Kris, Lee M. Krug, Quynh-Thu Le, Inga T. Lennes, Renato Martins, Janis O'Malley, Raymond U. Osarogiagbon, Gregory A. Otterson, Jyoti D. Patel, Katherine M. Pisters, Karen Reckamp, Gregory J. Riely, Eric Rohren, Scott J. Swanson, Douglas E. Wood and Stephen C. Yang

on the Internet. For the latest update, please visit www.NCCN.org . References 1. Strollo DC Rosado de Christenson ML Jett JR . Primary mediastinal tumors. Part 1: tumors of the anterior mediastinum . Chest 1997 ; 112 : 511 – 522

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David S. Ettinger, Gregory J. Riely, Wallace Akerley, Hossein Borghaei, Andrew C. Chang, Richard T. Cheney, Lucian R. Chirieac, Thomas A. D’Amico, Todd L. Demmy, Ramaswamy Govindan, Frederic W. Grannis Jr, Stefan C. Grant, Leora Horn, Thierry M. Jahan, Ritsuko Komaki, Feng-Ming (Spring) Kong, Mark G. Kris, Lee M. Krug, Rudy P. Lackner, Inga T. Lennes, Billy W. Loo Jr, Renato Martins, Gregory A. Otterson, Jyoti D. Patel, Mary C. Pinder-Schenck, Katherine M. Pisters, Karen Reckamp, Eric Rohren, Theresa A. Shapiro, Scott J. Swanson, Kurt Tauer, Douglas E. Wood, Stephen C. Yang, Kristina Gregory and Miranda Hughes

, treatment, and management of these mediastinal tumors. Mediastinal Masses Masses in the anterior mediastinum can be neoplasms (eg, thymomas, lymphomas, thymic carcinomas, thymic carcinoids, thymolipomas, germ cell tumors, lung metastases) or

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Richard T. Cheney

T umors of the thymus are rare, accounting for 0.2% to 1.5% of all malignancies. Thymomas account for 15% to 20% of all mediastinal tumors and are the most common anterior mediastinal tumor in adults, with a relatively equal sex distribution

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Frank C. Detterbeck

reproducible in the pathologist’s hands and more useful in the clinician’s hands for patient management. The initial focus of ITMIG was on thymoma, which constitutes the largest group of mediastinal tumors. However, many mediastinal malignancies are even

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Ronan J. Kelly

Thymic epithelial tumors account for approximately 20% of all mediastinal tumors. Nevertheless, they are rare compared with other malignancies, constituting only 0.2% to 1.5% of all solid tumors. 1 The WHO classification system distinguishes

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Douglas Arenberg and Ella A. Kazerooni

individuals (CI, 13.2%–15.2%; n = 4531) had clinically significant incidental findings requiring additional investigation. These abnormalities range from lung disease, such as pulmonary fibrosis or bronchiectasis, to aortic aneurysm, mediastinal tumors, and

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David S. Ettinger, Wallace Akerley, Gerold Bepler, Matthew G. Blum, Andrew Chang, Richard T. Cheney, Lucian R. Chirieac, Thomas A. D'Amico, Todd L. Demmy, Apar Kishor P. Ganti, Ramaswamy Govindan, Frederic W. Grannis Jr., Thierry Jahan, Mohammad Jahanzeb, David H. Johnson, Anne Kessinger, Ritsuko Komaki, Feng-Ming Kong, Mark G. Kris, Lee M. Krug, Quynh-Thu Le, Inga T. Lennes, Renato Martins, Janis O'Malley, Raymond U. Osarogiagbon, Gregory A. Otterson, Jyoti D. Patel, Katherine M. Pisters, Karen Reckamp, Gregory J. Riely, Eric Rohren, George R. Simon, Scott J. Swanson, Douglas E. Wood and Stephen C. Yang

general, photon beam energy between 4 and 10 MV is recommended for beams passing through low-density lung tissue before entering the tumor. For large mediastinal tumors or tumors attached to the chest wall, 15 or 18 MV energies can be considered for more