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Joyce Y. Wong and Vernon K. Sondak

.medscape.org/journal/jnccn ; (4) view/print certificate. Release date: March 5, 2012; Expiration date: March 5, 2013. Learning Objectives Upon completion of this activity, participants will be able to: Distinguish current recommendations for surgical margins in

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Vivek Verma, Amy C. Moreno, Waqar Haque, Penny Fang, and Steven H. Lin

with pN2 disease and those with pN1 disease not receiving chemotherapy 3 ; this has since been corroborated by large-volume retrospective studies. 4 , 5 PORT is also indicated for suspected or involved surgical margins. 1 , 6 , 7 However, what

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Lieke Gietelink, Michel W.J.M. Wouters, Pieter J. Tanis, Marion M. Deken, Martijn G. ten Berge, Rob A.E.M. Tollenaar, J. Han van Krieken, Mirre E. de Noo, and on behalf of the Dutch Surgical Colorectal Cancer Audit Group

)radiotherapy have led to improved oncologic outcomes. 2 , 3 The circumferential resection margin (CRM) indicates the distance from the tumor to the resection plane in a transverse section through the TME specimen. Tumor-negative noninvolved CRM is defined as the

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Susan Lester

without radiologic, visual, or palpable guidance, surgeons must make an educated guess as to where and how much tissue to remove. After removal, the surgeon should orient the specimen and mark the location of margins. This is important to help guide

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Daniel G. Coit, Robert Andtbacka, Christopher J. Anker, Christopher K. Bichakjian, William E. Carson III, Adil Daud, Raza A. Dilawari, Dominick DiMaio, Valerie Guild, Allan C. Halpern, F. Stephen Hodi Jr., Mark C. Kelley, Nikhil I. Khushalani, Ragini R. Kudchadkar, Julie R. Lange, Anne Lind, Mary C. Martini, Anthony J. Olszanski, Scott K. Pruitt, Merrick I. Ross, Susan M. Swetter, Kenneth K. Tanabe, John A. Thompson, Vijay Trisal, and Marshall M. Urist

. Clinical Presentation and Workup Biopsy Patients presenting with a suspicious pigmented lesion optimally should undergo an excisional biopsy, preferably with 1- to 3-mm margins. The orientation of the excisional biopsy should always be planned with

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Daniel G. Coit, Robert Andtbacka, Christopher K. Bichakjian, Raza A. Dilawari, Dominick DiMaio, Valerie Guild, Allan C. Halpern, F. Stephen Hodi, Mohammed Kashani-Sabet, Julie R. Lange, Anne Lind, Lainie Martin, Mary C. Martini, Scott K. Pruitt, Merrick I. Ross, Stephen F. Sener, Susan M. Swetter, Kenneth K. Tanabe, John A. Thompson, Vijay Trisal, Marshall M. Urist, Jeffrey Weber, and Michael K. Wong

early melanoma, should patients and family members be followed? Why and How? NIH Consensus Statement 1992 ; 10 : 1 – 26 . 34 Veronesi U Cascinelli N . Narrow excision (1-cm margin). A safe procedure for thin cutaneous melanoma . Arch

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John G. Huff

. To be regarded as a simple cyst, a mass must meet 3 criteria: its margins must be circumscribed (i.e., a margin “that is well defined or sharp, with an abrupt transition between the lesion and surrounding tissue” 3 ); it must be anechoic (i

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Charlotte E.L. Klaver, Lieke Gietelink, Willem A. Bemelman, Michel W.J.M. Wouters, Theo Wiggers, Rob A.E.M. Tollenaar, Pieter J. Tanis, and on behalf of the Dutch Surgical Colorectal Audit Group

postoperative course. The subcategories for radicality of resections were R0, which denoted complete tumor resection with all margins histologically uninvolved; R1, which denoted incomplete resection with microscopic surgical resection margin involvement; and R2

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Alyson Haslam, Jennifer Gill, and Vinay Prasad

prespecified margin. With this in mind, researchers, physicians, and patients are left to balance an acceptable loss in efficacy for alternative advantages, such as financial, physical, or ease of administration. 2 To determine NI, trials should use

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Robert E. Glasgow, David H. Ilson, James A. Hayman, Hans Gerdes, Mary F. Mulcahy, and Jaffer A. Ajani

, preferably, endoscopic mucosal resection (EMR) biopsy of the lesion to evaluate for submucosal extension. For patients with a T1aN0M0 tumor, treatment options include EMR with negative pathologic margins and ablation of at-risk adjacent mucosa or