Therapies such as thalidomide, bortezomib, and lenalidomide have provided meaningful benefits in multiple myeloma (MM), such as improved response rates and improved duration of response, but they have been associated with an increased risk of
Search Results
Ruben Niesvizky and Ashraf Z. Badros
Jacob P. Laubach, Constantine S. Mitsiades, Anuj Mahindra, Marlise R. Luskin, Jacalyn Rosenblatt, Irene M. Ghobrial, Robert L. Schlossman, David Avigan, Noopur Raje, Nikhil C. Munshi, Kenneth C. Anderson, and Paul G. Richardson
. Induction regimens that incorporate thalidomide, lenalidomide, and/or bortezomib are now standard for newly diagnosed MM in the United States. 8 – 12 Eligible patients may undergo autologous stem cell transplantation (ASCT), which deepens and prolongs the
Ashraf Z. Badros
randomized clinical trials of bortezomib and lenalidomide are underway ( Table 1 ). 12 Four randomized phase III trials have been completed to establish the role of thalidomide-based maintenance after ASCT ( Table 2 ). 13 – 16 In all 4 studies, improvements
Paul G. Richardson, Teru Hideshima, Constantine Mitsiades, and Kenneth C. Anderson
relapsed multiple myeloma: updated results of the APEX trial [abstract] . Blood 2005 ; 106 : 715a . Abstract 2547 . 20. Weber DM Chen C Niesvizky R . Lenalidomide plus high-dose dexamethasone provides improved survival compared to high
Jacob P. Laubach, Constantine S. Mitsiades, Anuj Mahindra, Robert L. Schlossman, Teru Hideshima, Dharminder Chauhan, Nicole A. Carreau, Irene M. Ghobrial, Noopur Raje, Nikhil C. Munshi, Kenneth C. Anderson, and Paul G. Richardson
-intensity autologous stem cell transplantation in elderly patients with multiple myeloma (IFM 99-06): a randomised trial . Lancet 2007 ; 370 : 1209 – 1218 . 36 Rajkumar SV Jacobus S Callander N . A randomized phase III trial of lenalidomide plus high
Jean-Luc Harousseau
Edited by Kerrin G. Robinson
IFM 2005/01 trial [abstract] . J Clin Oncol 2008 ; 26 ( Suppl 1 ): Abstract 455s . 31 Rajkumar SV Jacobus S Callander N . A randomized trial of lenalidomide plus high-dose dexamethasone versus lenalidomide plus low-dose dexamethasone in
Ashraf Badros
, bortezomib, and lenalidomide may neutralize the effects of negative prognostic factors. An effective means of risk stratification is required so that patients with poor risk may be offered more aggressive treatment or be entered into clinical trials of novel
Jean-Luc Harousseau and Philippe Moreau
. Combination therapy with lenalidomide plus dexamethasone (Rev/Dex) for newly diagnosed myeloma . Blood 2005 ; 106 : 4050 – 4053 . 27. Siegel DS Desikan KR Mehta J . Age is not a prognostic variable with autotransplants for multiple myeloma
Maria R. Baer and Ivana Gojo
% to 30% marrow blasts (azacitidine, decitabine) and for other indications (clofarabine, lenalidomide), those denied approval based on testing but that are still under evaluation (tipifarnib), and those still in early testing (sapacitabine). The novel
Philip L. McCarthy
increased. 1 This improved OS is likely from the use of novel agents that improve PFS, including the immunomodulatory drugs (IMiDs) thalidomide 2 , 3 and lenalidomide, 4 - 7 and the proteasome inhibitor bortezomib. 8 - 13 These drugs, usually as part of
