electrophoresis; KLC, kappa light chain; LDH, lactate dehydrogenase; SPEP, serum protein electrophoresis; SUV, standard uptake value; ULN, upper limit of normal. Although the patient did not harbor high-risk fluorescence in situ hybridization (FISH) changes, his
Radhika Gangaraju, Soo J. Kim, Jing-Fei Dong, Sabina Swierczek and Josef T. Prchal
normal at a clinic visit 6 weeks earlier). Her lactate dehydrogenase (LDH) level was 1,002 U/L (normal, 100–253 U/L), she had elevated reticulocytes at 11.3%, an indirect bilirubin level of 2.1 mg/dL, a creatinine level of 0.9 mg/dL, negative direct
Robert J. Motzer, Neeraj Agarwal, Clair Beard, Sam Bhayani, Graeme B. Bolger, Mark K. Buyyounouski, Michael A. Carducci, Sam S. Chang, Toni K. Choueiri, Shilpa Gupta, Steven L. Hancock, Gary R. Hudes, Eric Jonasch, Timothy M. Kuzel, Clayton Lau, Ellis G. Levine, Daniel W. Lin, Kim A. Margolin, M. Dror Michaelson, Thomas Olencki, Roberto Pili, Thomas W. Ratliff, Bruce G. Redman, Cary N. Robertson, Charles J. Ryan, Joel Sheinfeld, Jue Wang and Richard B. Wilder
, such as sarcoma or adenocarcinoma, and is then referred to as a teratoma with malignant transformation. The serum tumor markers alpha-fetoprotein (AFP), lactate dehydrogenase (LDH), and β-human chorionic gonadotropin (β-HCG) are critical in diagnosing
Michelle T. Ashworth and Adil Daud
lactate dehydrogenase (LDH) during treatment with ipilimumab with concurrent vemurafenib. For this patient’s first and second isolated metastases in 2009 and 2010, metastasectomy of resectable disease was a reasonable option, and remains in the
Nancy Kassem, Halima El Omri, Mohamed Yassin and Shereen Elazzazy
stratification was determined according to institutional guidelines based on disease, white blood cell count, lactate dehydrogenase level, renal function, and UA level. Results: A total of 103 patients who received rasburicase were evaluated retrospectively
Luciano J. Costa and Saad Z. Usmani
, lactate dehydrogenase; OS, overall survival; PFS, progression-free survival; R-ISS, Revised International Staging System. a High-risk FISH abnormalities: t(4;14), t(14;16), and/or del(17p). Cytogenetics Conventional metaphase cytogenetics is often “normal
Robert J. Motzer, Neeraj Agarwal, Clair Beard, Graeme B. Bolger, Barry Boston, Michael A. Carducci, Toni K. Choueiri, Robert A. Figlin, Mayer Fishman, Steven L. Hancock, Gary R. Hudes, Eric Jonasch, Anne Kessinger, Timothy M. Kuzel, Paul H. Lange, Ellis G. Levine, Kim A. Margolin, M. Dror Michaelson, Thomas Olencki, Roberto Pili, Bruce G. Redman, Cary N. Robertson, Lawrence H. Schwartz, Joel Sheinfeld and Jue Wang
Testicular Cancer Clinical Practice Guidelines in Oncology
NCCN Categories of Evidence and Consensus
Category 1: The recommendation is based on high-level evidence (e.g., randomized controlled trials) and there is uniform NCCN consensus.
Category 2A: The recommendation is based on lower-level evidence and there is uniform NCCN consensus.
Category 2B: The recommendation is based on lower-level evidence and there is nonuniform NCCN consensus (but no major disagreement).
Category 3: The recommendation is based on any level of evidence but reflects major disagreement.
All recommendations are category 2A unless otherwise noted.
Clinical trials: The NCCN believes that the best management for any cancer patient is in a clinical trial. Participation in clinical trials is especially encouraged.
Overview
An estimated 8090 new cases of testicular cancer will be diagnosed in the United States in 2008.1 Germ cell tumors (GCTs) comprise 95% of malignant tumors arising in the testes. These tumors also occur occasionally in extragonadal primary sites, but they are still managed the same as testicular GCTs. Although GCTs are relatively uncommon tumors that comprise only 2% of all human malignancies, they constitute the most common solid tumor in men between the ages of 15 and 34 years. In addition, the worldwide incidence of these tumors has more than doubled in the past 40 years.
Several risk factors for GCT development have been identified, including prior history, positive family history, cryptorchidism, testicular dysgenesis, and Klinefelter's syndrome. GCTs are classified as seminoma or nonseminoma. Nonseminomatous tumors often include multiple cell types, including embryonal cell...
Aby Z. Philip
retrospective study of 593 patients with SMZL conducted by Montalbán et al 4 identified hemoglobin concentration, platelet count, high lactate dehydrogenase (LDH) level, and extrahilar lymphadenopathy (outside the spleen and hepatic hila) as parameters
Eric Jonasch
factors associated with worse prognosis in RCC: Karnofsky performance status <80; low serum hemoglobin level; high corrected calcium level (10 mg/dL); high lactate dehydrogenase level (300 U/L); and no nephrectomy or <1 year from diagnosis to treatment. 4
Rajinder S. Grover, Kemp Kernstine and Amrita Krishnan
, lactate dehydrogenase level, performance status, and age, has improved the ability to predict outcome in diffuse large B-cell lymphoma (DLBCL). 1 In a patient with localized nonbulky early-stage disease (stage I–II) and no adverse prognostic factors
