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Robert J. Motzer, Neeraj Agarwal, Clair Beard, Sam Bhayani, Graeme B. Bolger, Michael A. Carducci, Sam S. Chang, Toni K. Choueiri, Steven L. Hancock, Gary R. Hudes, Eric Jonasch, David Josephson, Timothy M. Kuzel, Ellis G. Levine, Daniel W. Lin, Kim A. Margolin, M. Dror Michaelson, Thomas Olencki, Roberto Pili, Thomas W. Ratliff, Bruce G. Redman, Cary N. Robertson, Charles J. Ryan, Joel Sheinfeld, Philippe E. Spiess, Jue Wang and Richard B. Wilder

nephrectomy has well-established oncologic outcomes data comparable to radical nephrectomy, 14 , 17 – 19 which can lead to an increased risk of chronic kidney disease 20 , 21 that is associated with increased risks of cardiovascular morbidity and mortality

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Robert J. Motzer, Neeraj Agarwal, Clair Beard, Graeme B. Bolger, Barry Boston, Michael A. Carducci, Toni K. Choueiri, Robert A. Figlin, Mayer Fishman, Steven L. Hancock, Gary R. Hudes, Eric Jonasch, Anne Kessinger, Timothy M. Kuzel, Paul H. Lange, Ellis G. Levine, Kim A. Margolin, M. Dror Michaelson, Thomas Olencki, Roberto Pili, Bruce G. Redman, Cary N. Robertson, Lawrence H. Schwartz, Joel Sheinfeld and Jue Wang

Kidney Cancer Clinical Practice Guidelines in Oncology NCCN Categories of Evidence and Consensus Category 1: The recommendation is based on high-level evidence (e.g., randomized controlled trials) and there isuniform NCCN consensus. Category 2A: The recommendation is based on lower-level evidence and there is uniform NCCN consensus. Category 2B: The recommendation is based on lower-level evidence and there is nonuniform NCCN consensus (but no major disagreement). Category 3: The recommendation is based on any level of evidence but reflects major disagreement. All recommendations are category 2A unless otherwise noted. Clinical trials: The NCCN believes that the best management for any cancer patient is in a clinical trial. Participation in clinical trials is especially encouraged. Overview In 2008, an estimated 54,390 Americans were diagnosed with kidney cancer and 13,010 died of the disease in the United States.1 Renal cell carcinoma (RCC) comprises approximately 2% of all malignancies, with a median age at diagnosis of 65 years. The rate of RCC has increased 2% per year for the past 65 years. The reason for this increase is unknown. Approximately 90% of renal tumors are RCC, and 85% of these are clear cell tumors.2 Other, less-common cell types include papillary, chromophobe, and Bellini (collecting) duct tumors. Collecting duct carcinoma comprises fewer than 1% of all cases. Medullary renal carcinoma is a variant of collecting duct renal carcinoma and was initially described as occurring in patients who are sickle cell–trait positive. Smoking and obesity are among the risk factors for RCC development. Several hereditary types...
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Chunkit Fung, Paul C. Dinh Jr, Sophie D. Fossa and Lois B. Travis

,214 participants in the Platinum Study. CBM score accounts for the number and severity of the following adverse health outcomes: peripheral sensory neuropathy, autonomic neuropathy, hearing loss/damage, tinnitus, Raynaud phenomenon, pain, kidney disease

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Sarju Ganatra, Sourbha S. Dani, Robert Redd, Kimberly Rieger-Christ, Rushin Patel, Rohan Parikh, Aarti Asnani, Vigyan Bang, Katherine Shreyder, Simarjeet S. Brar, Amitoj Singh, Dhruv S. Kazi, Avirup Guha, Salim S. Hayek, Ana Barac, Krishna S. Gunturu, Corrine Zarwan, Anne C. Mosenthal, Shakeeb A. Yunus, Amudha Kumar, Jaymin M. Patel, Richard D. Patten, David M. Venesy, Sachin P. Shah, Frederic S. Resnic, Anju Nohria and Suzanne J. Baron

, cardiomyopathy, congestive heart failure, moderate to severe valvular heart disease, or ischemic stroke. Data Acquisition Patient demographics, comorbidities (including history of cancer, cardiovascular risk factors, preexisting CVD, chronic kidney disease [CKD

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Siyang Leng, Yizhen Chen, Wei-Yann Tsai, Divaya Bhutani, Grace C. Hillyer, Emerson Lim, Melissa K. Accordino, Jason D. Wright, Dawn L. Hershman, Suzanne Lentzsch and Alfred I. Neugut

, including acute kidney injury, chronic kidney disease, use of hemodialysis, osteoporosis, osteopenia, and hypercalcemia. Comorbidity score was assessed using the Klabunde adaptation of the Charlson comorbidity index. 21 The initial antineoplastic regimen

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Priya Wanchoo, Chris Larrison, Carol Rosenberg, Naomi Ko, Cynthia Cantril, Naomi Moeller, Ruchit Parikh and Ana-Marija Djordjevic

therapy, 16% would continue anastrozole and 7% would administer either single-agent or combination chemotherapy. Thus, 1 in 4 individuals would not make the optimal choice. Abbreviations: CAD, coronary artery disease; CKD, chronic kidney disease; COPD

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Adam J. Olszewski, Kalyan C. Mantripragada and Jorge J. Castillo

and health services using claims from 1 year preceding the DLBCL diagnosis. In particular, chronic kidney disease was defined as occurrence of any of the following codes from the ICD-9: 582.*, 583.*, 585.*, 586, or 588.*. Health services were

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Michael Xiang and Elizabeth A. Kidd

; SCC, squamous cell carcinoma. Determination of Study Variables and Outcomes Comorbidity was calculated using the Charlson comorbidity index as previously described. 17 Presence of chronic kidney disease was determined from claims before diagnosis, and

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Shreekant Parasuraman, Lincy Lal, Scott Bunner, Dilan Paranagama, Anna Teschemaker, Susan Snodgrass and Smitha Sivaraman

% were female, and 42% presented with metastatic disease ( Table 1 ). Notable comorbid conditions were liver disease (74%), chronic kidney disease (23%) and acute renal failure (18%). The median follow-up time was 224 days. Overall, 50% of the pts

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David Y. T. Chen and Robert G. Uzzo

Edited by Kerrin G. Robinson

McKiernan J Simmons R Katz J Russo P . Natural history of chronic renal insufficiency after partial and radical nephrectomy . Urology 2002 ; 59 : 816 – 820 . 8 Huang WC Levey AS Serio AM . Chronic kidney disease after nephrectomy in patients