Search Results

combination with ketoconazole in androgen-independent prostate cancer patients: A phase III trial (CALGB 9583) . J Clin Oncol 2004 ; 22 : 1025 – 1033 . 19 Veldscholte J Berrevoets C Mulder E . Studies on the human prostatic cancer cell line

fingers on his right hand. He was immediately started on high-dose ketoconazole (400 mg orally 3 times daily) along with hydrocortisone. One week later, his symptoms were stable. However, weakness persisted in the right upper extremity. A 240-mg loading

. A first-generation inhibitor of this enzyme is the antifungal agent ketoconazole, which in combination with hydrocortisone has shown clinical responses in patients with CRPC, 8 although it has not been shown to prolong survival in this population. 9

, such as aminoglutethimide, androgen-receptor antagonists, ketoconazole, adrenalectomy or hypophysectomy, and 5α-reductase inhibitors. 3 A study in the 1980s using aminoglutethimide suggested that the remaining androgenic drivers after surgical

symptoms, secondary hormone therapy is an existing option. Given its favorable toxicity profile compared with ketoconazole, abiraterone acetate is added as an alternative (category 2B). The panel acknowledges that some men with symptomatic metastatic CRPC

potential drug interactions. The azole antifungals are known inhibitors of CYP3A4. Both ketoconazole and voriconazole have been shown to increase plasma imatinib levels. 22 Other CYP3A4 inhibitors include verapamil, clarithromycin, and ritonavir. Ritonavir

1992 ; 99 : 68 – 70 . 18. Kim W Zhang L Wilton JH . Sequential use of the androgen synthesis inhibitors ketoconazole and abiraterone acetate in castration-resistant prostate cancer and the predictive value of circulating androgens . Clin

survival in men with castration-recurrent prostate cancer, and offers hope that ADT can be improved on when first instituted. The importance of ketoconazole (CYP17A1) for backdoor metabolism of adrenal androgens to DHT led to the redevelopment of

testing may have enhanced specificity for men receiving finasteride or dutasteride. Whether or not men should consider taking these agents for chemoprevention is beyond the scope of this guideline. Ketoconazole, commonly used to treat fungal conditions

, an oral, direct factor Xa inhibitor . Br J Clin Pharmacol 2013 ; 76 : 89 – 98 . 60. Frost CE Byon W Song Y . Effect of ketoconazole and diltiazem on the pharmacokinetics of apixaban, an oral direct factor Xa