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Charles J. Ryan and Eric J. Small

combination with ketoconazole in androgen-independent prostate cancer patients: A phase III trial (CALGB 9583) . J Clin Oncol 2004 ; 22 : 1025 – 1033 . 19 Veldscholte J Berrevoets C Mulder E . Studies on the human prostatic cancer cell line

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Venkata K. Pokuri, Houman Nourkeyhani, Bodie Betsy, Laurie Herbst, Marcus Sikorski, Edward Spangenthal, Andrew Fabiano and Saby George

fingers on his right hand. He was immediately started on high-dose ketoconazole (400 mg orally 3 times daily) along with hydrocortisone. One week later, his symptoms were stable. However, weakness persisted in the right upper extremity. A 240-mg loading

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Atish D. Choudhury and Philip W. Kantoff

. A first-generation inhibitor of this enzyme is the antifungal agent ketoconazole, which in combination with hydrocortisone has shown clinical responses in patients with CRPC, 8 although it has not been shown to prolong survival in this population. 9

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Dawn Goetz

, such as aminoglutethimide, androgen-receptor antagonists, ketoconazole, adrenalectomy or hypophysectomy, and 5α-reductase inhibitors. 3 A study in the 1980s using aminoglutethimide suggested that the remaining androgenic drivers after surgical

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James L. Mohler, Andrew J. Armstrong, Robert R. Bahnson, Barry Boston, J. Erik Busby, Anthony Victor D’Amico, James A. Eastham, Charles A. Enke, Thomas Farrington, Celestia S. Higano, Eric Mark Horwitz, Philip W. Kantoff, Mark H. Kawachi, Michael Kuettel, Richard J. Lee, Gary R. MacVicar, Arnold W. Malcolm, David Miller, Elizabeth R. Plimack, Julio M. Pow-Sang, Mack Roach III, Eric Rohren, Stan Rosenfeld, Sandy Srinivas, Seth A. Strope, Jonathan Tward, Przemyslaw Twardowski, Patrick C. Walsh, Maria Ho and Dorothy A. Shead

symptoms, secondary hormone therapy is an existing option. Given its favorable toxicity profile compared with ketoconazole, abiraterone acetate is added as an alternative (category 2B). The panel acknowledges that some men with symptomatic metastatic CRPC

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Stephen Harnicar

potential drug interactions. The azole antifungals are known inhibitors of CYP3A4. Both ketoconazole and voriconazole have been shown to increase plasma imatinib levels. 22 Other CYP3A4 inhibitors include verapamil, clarithromycin, and ritonavir. Ritonavir

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John J. Stocking, Michael V. Fiandalo, Elena A. Pop, John H. Wilton, Gissou Azabdaftari and James L. Mohler

1992 ; 99 : 68 – 70 . 18. Kim W Zhang L Wilton JH . Sequential use of the androgen synthesis inhibitors ketoconazole and abiraterone acetate in castration-resistant prostate cancer and the predictive value of circulating androgens . Clin

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James L. Mohler

survival in men with castration-recurrent prostate cancer, and offers hope that ADT can be improved on when first instituted. The importance of ketoconazole (CYP17A1) for backdoor metabolism of adrenal androgens to DHT led to the redevelopment of

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Peter R. Carroll, J. Kellogg Parsons, Gerald Andriole, Robert R. Bahnson, Daniel A. Barocas, Erik P. Castle, William J. Catalona, Douglas M. Dahl, John W. Davis, Jonathan I. Epstein, Ruth B. Etzioni, Thomas Farrington, George P. Hemstreet III, Mark H. Kawachi, Paul H. Lange, Kevin R. Loughlin, William Lowrance, Paul Maroni, James Mohler, Todd M. Morgan, Robert B. Nadler, Michael Poch, Chuck Scales, Terrence M. Shaneyfelt, Marc C. Smaldone, Geoffrey Sonn, Preston Sprenke, Andrew J. Vickers, Robert Wake, Dorothy A. Shead and Deborah Freedman-Cass

testing may have enhanced specificity for men receiving finasteride or dutasteride. Whether or not men should consider taking these agents for chemoprevention is beyond the scope of this guideline. Ketoconazole, commonly used to treat fungal conditions

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Michael B. Streiff, Bjorn Holmstrom, Dana Angelini, Aneel Ashrani, Paula L. Bockenstedt, Carolyn Chesney, John Fanikos, Randolph B. Fenninger, Annemarie E. Fogerty, Shuwei Gao, Samuel Z. Goldhaber, Krishna Gundabolu, Paul Hendrie, Alfred I. Lee, Jason T. Lee, Janelle Mann, Brandon McMahon, Michael M. Millenson, Colleen Morton, Thomas L. Ortel, Sadat Ozair, Rita Paschal, Sanford Shattil, Tanya Siddiqi, Kristi J. Smock, Gerald Soff, Tzu-Fei Wang, Eliot Williams, Anaadriana Zakarija, Lydia Hammond, Mary A. Dwyer and Anita M. Engh

, an oral, direct factor Xa inhibitor . Br J Clin Pharmacol 2013 ; 76 : 89 – 98 . 60. Frost CE Byon W Song Y . Effect of ketoconazole and diltiazem on the pharmacokinetics of apixaban, an oral direct factor Xa