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Radhika Gangaraju, Soo J. Kim, Jing-Fei Dong, Sabina Swierczek, and Josef T. Prchal

antibiotics, chemotherapy, immunosuppressants, narcotics, and cardiac medications. 6 , 7 We report a case of TTP due to the development of antibodies to ADAMTS13 in association with pegylated interferon alfa-2a (pegIFNa) use in a patient with polycythemia

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Michael S. Sabel and Vernon K. Sondak

: 3635 – 3648 . 2 Dickler MN Coit DG Myers ML . Adjuvant therapy of malignant melanoma . Surg Oncol Clin N Am 1997 ; 6 : 793 – 812 . 3 Pfeffer LM Dinarello CA Herberman RB . Biological properties of recombinant alpha-interferons

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Paul B. Chapman

analysis of 17,600 melanoma patients: validation of the American Joint Committee on Cancer melanoma staging system . J Clin Oncol 2001 ; 19 : 3622 – 3634 . 2 Kirkwood JM Strawderman MH Ernstoff MS . Interferon alfa-2b adjuvant therapy of high

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Leslie A. Fecher and Keith T. Flaherty

2004 ; 139 : 961 – 967 . 9 Neuman H Patel A Hanlon C . Stage-IV melanoma and pulmonary metastases: factors predictive of survival . Ann Surg Oncol 2007 ; 14 : 2847 – 2853 . 10 Kirkwood J Strawderman M Ernstoff M . Interferon

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Ashraf Z. Badros

patterns vary considerably because of conflicting data about its effectiveness. Currently, NCCN recommends thalidomide (category 1 recommendation) with or without prednisone (category 2B) for maintenance therapy; the roles of interferon and corticosteroids

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Daniel G. Coit, Robert Andtbacka, Christopher K. Bichakjian, Raza A. Dilawari, Dominick DiMaio, Valerie Guild, Allan C. Halpern, F. Stephen Hodi, Mohammed Kashani-Sabet, Julie R. Lange, Anne Lind, Lainie Martin, Mary C. Martini, Scott K. Pruitt, Merrick I. Ross, Stephen F. Sener, Susan M. Swetter, Kenneth K. Tanabe, John A. Thompson, Vijay Trisal, Marshall M. Urist, Jeffrey Weber, and Michael K. Wong

dissection for melanoma . J Clin Oncol 2004 ; 22 : 3677 – 3684 . 70 Cascinelli N Belli F MacKie RM . Effect of long-term adjuvant therapy with interferon alpha-2a in patients with regional node metastases from cutaneous melanoma: a randomised

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Daniel G. Coit, Robert Andtbacka, Christopher J. Anker, Christopher K. Bichakjian, William E. Carson III, Adil Daud, Raza A. Dilawari, Dominick DiMaio, Valerie Guild, Allan C. Halpern, F. Stephen Hodi Jr., Mark C. Kelley, Nikhil I. Khushalani, Ragini R. Kudchadkar, Julie R. Lange, Anne Lind, Mary C. Martini, Anthony J. Olszanski, Scott K. Pruitt, Merrick I. Ross, Susan M. Swetter, Kenneth K. Tanabe, John A. Thompson, Vijay Trisal, and Marshall M. Urist

-Dose Interferon The first major randomized trial of adjuvant interferon for completely resected stage III melanoma conducted by the WHO 72 showed no improvement in overall survival (35% for the interferon group vs. 37% for those assigned to observation alone

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Jorge Cortes, John M. Goldman, and Timothy Hughes

milestones shown in Table 1 with respect to specific time points. 2 - 4 The ELN and NCCN Guidelines recommendations were based largely on response data from the IRIS (International Randomized Study of Interferon and STI571) study, which compared the

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Eric Jonasch and Robert J. Motzer

indication. 2 In the next 5 years, bevacizumab plus interferon (IFN) α, 7 pazopanib, 4 and axitinib 5 were also approved. Figure 1 Advances in the treatment of RCC, 2002–2012. Abbreviations: IFN, interferon; OS, overall survival; RCC, renal cell

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Eric Jonasch

Figure 1. Lines of treatment in advanced renal cell carcinoma. Abbreviations: HD, high dose; IFN, interferon; IL, interleukin; MSKCC, Memorial Sloan Kettering Cancer Center; RCC, renal cell carcinoma; VEGFR, vascular endothelial growth factor receptor