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Lindsey Robert Baden, William Bensinger, Michael Angarone, Corey Casper, Erik R. Dubberke, Alison G. Freifeld, Ramiro Garzon, John N. Greene, John P. Greer, James I. Ito, Judith E. Karp, Daniel R. Kaul, Earl King, Emily Mackler, Kieren A. Marr, Jose G. Montoya, Ashley Morris-Engemann, Peter G. Pappas, Ken Rolston, Brahm Segal, Susan K. Seo, Sankar Swaminathan, Maoko Naganuma and Dorothy A. Shead

Infectious diseases are important causes of morbidity and mortality in patients with cancer. In certain instances, the malignancy itself can predispose patients to severe or recurrent infections. Neutropenia has been recognized for many decades as a major

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Lindsey Robert Baden, Sankar Swaminathan, Michael Angarone, Gayle Blouin, Bernard C. Camins, Corey Casper, Brenda Cooper, Erik R. Dubberke, Ashley Morris Engemann, Alison G. Freifeld, John N. Greene, James I. Ito, Daniel R. Kaul, Mark E. Lustberg, Jose G. Montoya, Ken Rolston, Gowri Satyanarayana, Brahm Segal, Susan K. Seo, Shmuel Shoham, Randy Taplitz, Jeffrey Topal, John W. Wilson, Karin G. Hoffmann and Courtney Smith

There is an increased risk of infection in patients with cancer that results in higher morbidity and mortality. In certain instances, the cancer itself can predispose patients to severe or recurrent infections. Neutropenia has been recognized as a major

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Crystal S. Denlinger, Jennifer A. Ligibel, Madhuri Are, K. Scott Baker, Wendy Demark-Wahnefried, Don Dizon, Debra L. Friedman, Mindy Goldman, Lee Jones, Allison King, Grace H. Ku, Elizabeth Kvale, Terry S. Langbaum, Kristin Leonardi-Warren, Mary S. McCabe, Michelle Melisko, Jose G. Montoya, Kathi Mooney, Mary Ann Morgan, Javid J. Moslehi, Tracey O’Connor, Linda Overholser, Electra D. Paskett, Jeffrey Peppercorn, Muhammad Raza, M. Alma Rodriguez, Karen L. Syrjala, Susan G. Urba, Mark T. Wakabayashi, Phyllis Zee, Nicole R. McMillian and Deborah A. Freedman-Cass

are at elevated risk for infection because of immune suppression associated with previous cancer treatments, such as chemotherapy, radiation, corticosteroids, certain surgeries, and stem cell transplantation. In fact, antibody titers to vaccine

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Arjun Gupta, Raseen Tariq, Ryan D. Frank, Gary W. Jean, Muhammad S. Beg, Darrell S. Pardi, David H. Johnson and Sahil Khanna

Clostridium difficile infection (CDI) is the most common nosocomial infection in the United States, 1 with increasing recognition in the community. 2 , 3 An increase in incidence and severity of CDI has been observed despite increased awareness

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Maxim Norkin and John R. Wingard

Because of prolonged neutropenia and severe immunosuppression, patients with hematologic malignancies (HMs) and hematopoietic stem cell transplant (HSCT) recipients are at high risk for invasive fungal infections (IFIs), which are associated with

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Harrys A. Torres, Parag Mahale, Boris Blechacz, Ethan Miller, Ahmed Kaseb, H. Franklin Herlong, Nathan Fowler, Ying Jiang, Issam I. Raad and Dimitrios P. Kontoyiannis

from hepatic and extrahepatic diseases. 3 The prevalence of HCV infection in patients with cancer ranges from 1.5% to 32.0%. 4 – 7 Despite the recent interest in HCV, 8 it is a neglected infection in patients with cancer, with little known about its

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Eric J. Bow

relationships between circulating leukocytes and infection in patients with acute leukemia . Ann Intern Med 1966 ; 64 : 328 – 340 . 2 Garcia-Rodriguez JA Gobernado M Gomis M . [Clinical guide for the evaluation and treatment of patients with

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Thomas A. Cumbo and Brahm H. Segal

1 Bow EJ Loewen R Cheang MS . Cytotoxic therapy-induced D-xylose malabsorption and invasive infection during remission-induction therapy for acute myeloid leukemia in adults . J Clin Oncol 1997 ; 15 : 2254 – 2261 . 2 Pfaller MA

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Antonio V. Gonzalez, Andrew J. Ullmann, Nikolaos G. Almyroudis and Brahm H. Segal

Pfizer. References 1. Ascioglu S Rex JH de Pauw B . Defining opportunistic invasive fungal infections in immunocompromised patients with cancer and hematopoietic stem cell transplants: an international consensus . Clin Infect Dis 2002

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Johan Maertens, Kristel Buvé and Elias Anaissie

. Goodman JL Winston DJ Greenfield RA . A controlled trial of fluconazole to prevent fungal infections in patients undergoing bone marrow transplantation . N Engl J Med 1992 ; 326 : 845 – 851 . 2. Slavin MA Osborne B Adams R . Efficacy and