Infectious diseases are important causes of morbidity and mortality in patients with cancer. In certain instances, the malignancy itself can predispose patients to severe or recurrent infections. Neutropenia has been recognized for many decades as a major
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Lindsey Robert Baden, William Bensinger, Michael Angarone, Corey Casper, Erik R. Dubberke, Alison G. Freifeld, Ramiro Garzon, John N. Greene, John P. Greer, James I. Ito, Judith E. Karp, Daniel R. Kaul, Earl King, Emily Mackler, Kieren A. Marr, Jose G. Montoya, Ashley Morris-Engemann, Peter G. Pappas, Ken Rolston, Brahm Segal, Susan K. Seo, Sankar Swaminathan, Maoko Naganuma, and Dorothy A. Shead
Lindsey Robert Baden, Sankar Swaminathan, Michael Angarone, Gayle Blouin, Bernard C. Camins, Corey Casper, Brenda Cooper, Erik R. Dubberke, Ashley Morris Engemann, Alison G. Freifeld, John N. Greene, James I. Ito, Daniel R. Kaul, Mark E. Lustberg, Jose G. Montoya, Ken Rolston, Gowri Satyanarayana, Brahm Segal, Susan K. Seo, Shmuel Shoham, Randy Taplitz, Jeffrey Topal, John W. Wilson, Karin G. Hoffmann, and Courtney Smith
There is an increased risk of infection in patients with cancer that results in higher morbidity and mortality. In certain instances, the cancer itself can predispose patients to severe or recurrent infections. Neutropenia has been recognized as a major
Crystal S. Denlinger, Jennifer A. Ligibel, Madhuri Are, K. Scott Baker, Wendy Demark-Wahnefried, Don Dizon, Debra L. Friedman, Mindy Goldman, Lee Jones, Allison King, Grace H. Ku, Elizabeth Kvale, Terry S. Langbaum, Kristin Leonardi-Warren, Mary S. McCabe, Michelle Melisko, Jose G. Montoya, Kathi Mooney, Mary Ann Morgan, Javid J. Moslehi, Tracey O’Connor, Linda Overholser, Electra D. Paskett, Jeffrey Peppercorn, Muhammad Raza, M. Alma Rodriguez, Karen L. Syrjala, Susan G. Urba, Mark T. Wakabayashi, Phyllis Zee, Nicole R. McMillian, and Deborah A. Freedman-Cass
are at elevated risk for infection because of immune suppression associated with previous cancer treatments, such as chemotherapy, radiation, corticosteroids, certain surgeries, and stem cell transplantation. In fact, antibody titers to vaccine
Arjun Gupta, Raseen Tariq, Ryan D. Frank, Gary W. Jean, Muhammad S. Beg, Darrell S. Pardi, David H. Johnson, and Sahil Khanna
Clostridium difficile infection (CDI) is the most common nosocomial infection in the United States, 1 with increasing recognition in the community. 2 , 3 An increase in incidence and severity of CDI has been observed despite increased awareness
Maxim Norkin and John R. Wingard
Because of prolonged neutropenia and severe immunosuppression, patients with hematologic malignancies (HMs) and hematopoietic stem cell transplant (HSCT) recipients are at high risk for invasive fungal infections (IFIs), which are associated with
Harrys A. Torres, Parag Mahale, Boris Blechacz, Ethan Miller, Ahmed Kaseb, H. Franklin Herlong, Nathan Fowler, Ying Jiang, Issam I. Raad, and Dimitrios P. Kontoyiannis
from hepatic and extrahepatic diseases. 3 The prevalence of HCV infection in patients with cancer ranges from 1.5% to 32.0%. 4 – 7 Despite the recent interest in HCV, 8 it is a neglected infection in patients with cancer, with little known about its
Douglas W. Blayney, Nicole M. Kuderer, Alice Kate Cummings Joyner, John Jarvis, Dominic Nunag, Jasmine Wells, Lan Huang, Ramon Monhanlal, and Gary H. Lyman
studies have investigated the effect of prophylactic G-CSF use on time to neutrophil nadir following chemotherapy. 3 , 4 However, little is known about the relationship between G-CSF prophylaxis and the timing of incident FN and infection within the
Eric J. Bow
relationships between circulating leukocytes and infection in patients with acute leukemia . Ann Intern Med 1966 ; 64 : 328 – 340 . 2 Garcia-Rodriguez JA Gobernado M Gomis M . [Clinical guide for the evaluation and treatment of patients with
William Alegria, Bernard L. Marini, Kevin Sellery Gregg, Dale Lee Bixby, Anthony Perissinotti, and Jerod Nagel
for high-risk patients with FN. 1 NCCN suggests that de-escalation can be considered in patients without documented infection. In patients with documented infection, de-escalation may be influenced by neutrophil recovery, defervescence, infection site
Thomas A. Cumbo and Brahm H. Segal
1 Bow EJ Loewen R Cheang MS . Cytotoxic therapy-induced D-xylose malabsorption and invasive infection during remission-induction therapy for acute myeloid leukemia in adults . J Clin Oncol 1997 ; 15 : 2254 – 2261 . 2 Pfaller MA
