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Ellen L. Jones, Lawrence B. Marks, and Leonard R. Prosnitz

Dr. Jones receives support for hyperthermia research from NIH grant P01 CA42745. The other authors have no financial interest, arrangement, or affiliation with the manufacturers of any products discussed in the article or their competitors

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Beryl McCormick

The author has no financial interest, arrangement, or affiliation with the manufacturers of any products discussed in the article or their competitors. References 1. Perez C Emami B Nussbaum G Sapareto S . Hyperthermia . In

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Scott M. Schuetze and Michael E. Ray

with regional hyperthermia (RHT) for locally advanced primary or recurrent high-risk adult soft-tissue sarcomas (STS) of adults: long-term results of a phase II study . Eur J Cancer 2001 ; 37 : 1599 – 1608 . 38 Wendtner CM Abdel-Rahman S

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Prashant Gabani, Emily Merfeld, Amar J. Srivastava, Ashley A. Weiner, Laura L. Ochoa, Dan Mullen, Maria A. Thomas, Julie A. Margenthaler, Amy E. Cyr, Lindsay L. Peterson, Michael J. Naughton, Cynthia Ma, and Imran Zoberi

setting and in patients whose disease is resistant to first-line chemotherapy. 29 – 31 Likewise, hyperthermia is a well-known radiosensitizer, and its combination with RT has demonstrated improved local control compared with RT alone in randomized studies

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Rachel A. Bender Ignacio, Lilie L. Lin, Lakshmi Rajdev, and Elizabeth Chiao

locally advanced cervical cancer in South Africa (NCT03332069). Previous studies have shown that the addition of hyperthermia to conventional cytotoxic therapy improves treatment efficacy. 18 mEHT utilizes the principles of extracellular hyperthermia

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Anthony Eidelman, Traci White, and Robert A. Swarm

. 39. Fan QY Ma BA Qlu XC . Preliminary report on treatment of bone tumors with microwave-induced hyperthermia . Bioelectromagnetics 1996 ; 17 : 218 – 222 . 40. Masala S Roselli M Massari F . Radiofrequency heat ablation and

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Michael W. Lew, Andres Falabella, Earl Moore-Jeffries, Russell J. Gray, and Michael J. Sullivan

cerebral protection . J Neurosurg 1988 ; 68 : 868 – 879 . 42. Dubois M Coppola R Buchsbaum MS Lees DE . Somatosensory evoked potentials during whole body hyperthermia in humans . Electroencephalogr Clin Neurophysiol 1981 ; 52 : 157 – 162

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NCCN Guidelines Insights: Ovarian Cancer, Version 1.2019

Featured Updates to the NCCN Guidelines

Deborah K. Armstrong, Ronald D. Alvarez, Jamie N. Bakkum-Gamez, Lisa Barroilhet, Kian Behbakht, Andrew Berchuck, Jonathan S. Berek, Lee-may Chen, Mihaela Cristea, Marie DeRosa, Adam C. ElNaggar, David M. Gershenson, Heidi J. Gray, Ardeshir Hakam, Angela Jain, Carolyn Johnston, Charles A. Leath III, Joyce Liu, Haider Mahdi, Daniela Matei, Michael McHale, Karen McLean, David M. O’Malley, Richard T. Penson, Sanja Percac-Lima, Elena Ratner, Steven W. Remmenga, Paul Sabbatini, Theresa L. Werner, Emese Zsiros, Jennifer L. Burns, and Anita M. Engh

stage III ovarian cancer . N Engl J Med 1996 ; 335 : 1950 – 1955 . 10.1056/NEJM199612263352603 8960474 31. van de Vaart PJ , van der Vange N , Zoetmulder FA , . Intraperitoneal cisplatin with regional hyperthermia in advanced ovarian cancer

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Robert W. Carlson, D. Craig Allred, Benjamin O. Anderson, Harold J. Burstein, W. Bradford Carter, Stephen B. Edge, John K. Erban, William B. Farrar, Lori J. Goldstein, William J. Gradishar, Daniel F. Hayes, Clifford A. Hudis, Mohammad Jahanzeb, Krystyna Kiel, Britt-Marie Ljung, P. Kelly Marcom, Ingrid A. Mayer, Beryl McCormick, Lisle M. Nabell, Lori J. Pierce, Elizabeth C. Reed, Mary Lou Smith, George Somlo, Richard L. Theriault, Neal S. Topham, John H. Ward, Eric P. Winer, and Antonio C. Wolff

detection of recurrent or metastatic breast carcinoma . J Nucl Med 1998 ; 39 : 431 – 435 . 207 Vernon CC Hand JW Field SB . Radiotherapy with or without hyperthermia in the treatment of superficial localized breast cancer: results from five

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Thomas Schmidt, Florian Lordick, Ken Herrmann, and Katja Ott

. Monitoring of response to pre-operative chemoradiation in combination with hyperthermia in oesophageal cancer by FDG-PET . Int J Hyperthermia 2006 ; 22 : 149 – 160 . 84. Ott K Herrmann K Lordick F . Early metabolic response evaluation by