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Breast Cancer Screening and Diagnosis

Therese B. Bevers, Benjamin O. Anderson, Ermelinda Bonaccio, Sandra Buys, Mary B. Daly, Peter J. Dempsey, William B. Farrar, Irving Fleming, Judy E. Garber, Randall E. Harris, Alexandra S. Heerdt, Mark Helvie, John G. Huff, Nazanin Khakpour, Seema A. Khan, Helen Krontiras, Gary Lyman, Elizabeth Rafferty, Sara Shaw, Mary Lou Smith, Theodore N. Tsangaris, Cheryl Williams, and Thomas Yankeelov

) or atypical hyperplasia; and 6) women with a prior history of breast cancer. Women at Normal Risk: For women between 20 and 39 years of age, a CBE every 1 to 3 years is recommended, with breast awareness encouraged. For women aged 40 years and

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Fine-Needle Aspiration Biopsy of Palpable Breast Masses: Patterns of Clinical Use and Patient Experience

Amy Ly, Jill C. Ono, Kevin S. Hughes, Martha B. Pitman, and Ronald Balassanian

findings. Benign Table 1. Patient Demographics diagnoses included fibrous tissue/scar, fibrocystic change, mastitis, keratin cyst, bacterial infection, pseudoangiomatous stromal hyperplasia, fat necrosis, lipoma, fibroadenoma, hamartoma

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Diagnosis and Management of High-Risk Breast Lesions

Parijatham S. Thomas

benign disease. 1 However, not all benign breast biopsies are equal, and certain lesions confer an increased risk for breast cancer. Specifically, lesions with atypical hyperplasia (AH) and lobular carcinoma in situ (LCIS) have been shown to be

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Evolving Concepts in the Management of Lobular Neoplasia

Benjamin O. Anderson, Kristine E. Calhoun, and Eric L. Rosen

mucin-secreting carcinoma . J Clin Pathol 1975 ; 28 : 711 – 716 . 22. Rosen P . Lobular carcinoma and hyperplasia . In: Rosen P, ed. Breast Pathology . Philadelphia : Lippincott-Raven ; 1997 : 507 – 544 . 23. Acs G Lawton

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JAK2 R683S Mutation Resulting in Dual Diagnoses of Chronic Eosinophilic Leukemia and Myelodysplastic/Myeloproliferative Overlap Syndrome

Nathan M. Krah, Laura Miotke, Peng Li, Jay L. Patel, Anneli R. Bowen, Anthony D. Pomicter, and Ami B. Patel

hypercellular marrow (95%) with multilineage dysplasia, myeloid and megakaryocytic hyperplasia, and markedly increased eosinophils (18.7%). There was no increase in blasts. Conventional cytogenetics and fluorescence in situ hybridization (FISH) panel for

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Controversies in the Evaluation and Management of Atypical Melanocytic Proliferations in Children, Adolescents, and Young Adults

Damon Reed, Ragini Kudchadkar, Jonathan S. Zager, Vernon K. Sondak, and Jane L. Messina

. (C) Spitzoid melanoma from 17-year-old patient. Although resembling a Spitz nevus by virtue of epidermal hyperplasia and epithelioid cell component, there is marked atypical and sheet-like growth of dermal component, with severe pleomorphism in the

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A Cryptic BCR-PDGFRB Fusion Resulting in a Chronic Myeloid Neoplasm With Monocytosis and Eosinophilia: A Novel Finding With Treatment Implications

Sanjeev Kumar Gupta, Nitin Jain, Guilin Tang, Andrew Futreal, Sa A. Wang, Joseph D. Khoury, Richard K. Yang, Hong Fang, Keyur P. Patel, Rajyalakshmi Luthra, Mark Routbort, Bedia A. Barkoh, Wei Chen, Xizeng Mao, Jianhua Zhang, L. Jeffrey Medeiros, Carlos E. Bueso-Ramos, and Sanam Loghavi

–11 × 10 9 /L), and a normal platelet count (152 × 10 9 /L; reference, 150–450 × 10 9 /L). The differential leukocyte count showed monocytosis (47%) and eosinophilia (15%). BM examination showed hypercellular (∼95%) BM with myelomonocytic hyperplasia and

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Barriers to the Use of Breast Cancer Risk Reduction Therapies

Arvind Bambhroliya, Mariana Chavez-MacGregor, and Abenaa M. Brewster

higher self-perceived risk of developing breast cancer is positively associated with acceptance of risk reduction medications, 35 , 38 and uptake has been shown to be significantly higher among women with a history of atypical hyperplasia or LCIS 17 , 20

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Rapid Clinical and Radiographic Response With Combined Dabrafenib and Trametinib in Adults With BRAF-Mutated High-Grade Glioma

Tanner M. Johanns, Cole J. Ferguson, Patrick M. Grierson, Sonika Dahiya, and George Ansstas

, and predominantly epithelioid morphology ( Figure 1A ). Although necrosis was not convincingly present, large areas of hemorrhage, focal endothelial hyperplasia ( Figure 1B ) and vascular thrombosis were present. The tumor was widely infiltrative

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Breast Cancer Risk Reduction

Therese B. Bevers, Deborah K. Armstrong, Banu Arun, Robert W. Carlson, Kenneth H. Cowan, Mary B. Daly, Irvin Fleming, Judy E. Garber, Mary Gemignani, William J. Gradishar, Helen Krontiras, Swati Kulkarni, Christine Laronga, Loretta Loftus, Deborah J. MacDonald, Martin C. Mahoney, Sofia D. Merajver, Ingrid Meszoely, Lisa Newman, Elizabeth Pritchard, Victoria Seewaldt, Rena V. Sellin, Charles L. Shapiro, and John H. Ward

Hodgkin disease], hormone replacement therapy [HRT], alcohol consumption); and other factors (e.g., number of breast biopsies, atypical hyperplasia or lobular carcinoma in situ [LCIS], breast density, body mass index). Estimating breast cancer risk for