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Susan M. Domchek, Jill E. Stopfer, and Timothy R. Rebbeck

's Health Initiative findings . Pharmacoepidemiol Drug Saf 2005 ; 5 : 5 . 35. Rebbeck TR Friebel T Wagner TM . Effect of short term hormone replacement therapy on breast cancer risk reduction after bilateral prophylactic oophorectomy in BRCA1

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Therese B. Bevers, Deborah K. Armstrong, Banu Arun, Robert W. Carlson, Kenneth H. Cowan, Mary B. Daly, Irvin Fleming, Judy E. Garber, Mary Gemignani, William J. Gradishar, Helen Krontiras, Swati Kulkarni, Christine Laronga, Loretta Loftus, Deborah J. MacDonald, Martin C. Mahoney, Sofia D. Merajver, Ingrid Meszoely, Lisa Newman, Elizabeth Pritchard, Victoria Seewaldt, Rena V. Sellin, Charles L. Shapiro, and John H. Ward

Hodgkin disease], hormone replacement therapy [HRT], alcohol consumption); and other factors (e.g., number of breast biopsies, atypical hyperplasia or lobular carcinoma in situ [LCIS], breast density, body mass index). Estimating breast cancer risk for

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David S. Ettinger, Wallace Akerley, Gerold Bepler, Matthew G. Blum, Andrew Chang, Richard T. Cheney, Lucian R. Chirieac, Thomas A. D'Amico, Todd L. Demmy, Apar Kishor P. Ganti, Ramaswamy Govindan, Frederic W. Grannis Jr., Thierry Jahan, Mohammad Jahanzeb, David H. Johnson, Anne Kessinger, Ritsuko Komaki, Feng-Ming Kong, Mark G. Kris, Lee M. Krug, Quynh-Thu Le, Inga T. Lennes, Renato Martins, Janis O'Malley, Raymond U. Osarogiagbon, Gregory A. Otterson, Jyoti D. Patel, Katherine M. Pisters, Karen Reckamp, Gregory J. Riely, Eric Rohren, George R. Simon, Scott J. Swanson, Douglas E. Wood, and Stephen C. Yang

. Data suggest that postmenopausal women who smoke or are former smokers should not undergo hormone replacement therapy, because it increases the risk for death from non–small cell lung cancer (NSCLC). 5 Asbestos, a mineral compound that breaks into

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Robert W. Carlson, D. Craig Allred, Benjamin O. Anderson, Harold J. Burstein, W. Bradford Carter, Stephen B. Edge, John K. Erban, William B. Farrar, Andres Forero, Sharon Hermes Giordano, Lori J. Goldstein, William J. Gradishar, Daniel F. Hayes, Clifford A. Hudis, Britt-Marie Ljung, David A. Mankoff, P. Kelly Marcom, Ingrid A. Mayer, Beryl McCormick, Lori J. Pierce, Elizabeth C. Reed, Jasgit Sachdev, Mary Lou Smith, George Somlo, John H. Ward, Antonio C. Wolff, and Richard Zellars

first live birth, prolonged hormone replacement therapy, previous exposure to therapeutic chest wall irradiation, benign proliferative breast disease, and genetic mutations, such as of the BRCA1/2 genes. However, except for female sex and increasing

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Mary Daly

combination hormone replacement therapy, are modifiable. Experts estimate that 15% of overall breast cancer risk is attributable to weight gain in adulthood. Moderate physical activity is estimated to decrease breast cancer risk by 15% to 25%. The relative

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Rowan T. Chlebowski, Aaron K. Aragaki, and Garnet L. Anderson

Engl J Med 1976 ; 295 : 401 – 405 . 5. Collaborative Group on Hormonal Factors in Breast Cancer . Breast cancer and hormone replacement therapy: collaborative reanalysis of data from 51 epidemiological studies of 52,705 women with breast

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Stephanie Andrews

weight; and feeling more tired, warmer, or colder than usual; persistent or unusual headache; changes in mood or behavior; hair loss; deeper voice; and constipation. For hypothyroidism, thyroid hormone replacement therapy can be given as needed, without

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Martin C. Mahoney

. Rossouw JE Anderson GL Prentice RL . Risks and benefits of estrogen plus progestin in healthy postmenopausal women . JAMA 2002 ; 288 : 321 – 333 . 21. Ross RK Paganini-Hill A Wan PC Pike MC . Effect of hormone replacement therapy on breast

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Mindy E. Goldman

hormone replacement therapy tend to abruptly stop when diagnosed with endocrine-dependent cancers; and vasomotor symptoms are common with hormonal drugs such as tamoxifen or aromatase inhibitors. For Dr. Goldman, the key is to be sure that menopausal

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Emma Gargus, Rebecca Deans, Antoinette Anazodo, and Teresa K. Woodruff

POI. 57 Evidence regarding the use of hormone replacement therapy (HRT) in survivors of childhood cancer is even more limited. However, evidence suggests that women who do not receive HRT have increased mortality compared with those who receive