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Kenneth Offit

multigene testing for hereditary cancer syndromes and discussed situations in which multigene testing should be considered. “Someday, we'll be able to spit into our smart phones, and get a genetic readout and online counseling, but we are not there yet

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Thai H. Ho and Eric Jonasch

Hereditary renal cell carcinoma (RCC) has been estimated to account for 5% to 8% of all RCC cases, and extrarenal manifestations may present as early as 3 years of age ( Table 1 ). 1 , 2 RCC is a diverse set of cancers that originate from the

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Rishi Jain, Michelle J. Savage, Andrea D. Forman, Reetu Mukherji and Michael J. Hall

Discuss the importance of genetic counseling when using TGP for patients with cancer Genetic testing to inform disease prognostication, therapy targeting, and hereditary cancer risk assessment is increasingly critical to oncology care. The emergence

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Patrick M. Lynch

performance of genetic counselor–driven germline mutation testing, in patients with hereditary nonpolyposis colorectal cancer (HNPCC)–related tumors, also known as Lynch syndrome. Suitably aggressive colorectal neoplasm surveillance is shown to be critical

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Stephen B. Gruber and Wendy Kohlmann

No benefits in any form have been or will be received from a commercial party related directly or indirectly to the subject of this article. References 1 Lynch HT Shaw MW Magnuson CW . Hereditary factors in cancer: Study of two

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Jennifer B. Ogilvie and Electron Kebebew

lymph node dissection in sporadic and hereditary medullary thyroid cancer . J Clin Endocrinol Metab 2003 ; 88 : 2070 – 2075 . 8. Quayle FJ Moley JF . Medullary thyroid carcinoma: including MEN 2A and MEN 2B syndromes . J Surg Oncol 2005

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Mary B. Daly, Jennifer E. Axilbund, Saundra Buys, Beth Crawford, Carolyn D. Farrell, Susan Friedman, Judy E. Garber, Salil Goorha, Stephen B. Gruber, Heather Hampel, Virginia Kaklamani, Wendy Kohlmann, Allison Kurian, Jennifer Litton, P. Kelly Marcom, Robert Nussbaum, Kenneth Offit, Tuya Pal, Boris Pasche, Robert Pilarski, Gwen Reiser, Kristen Mahoney Shannon, Jeffrey R. Smith, Elizabeth Swisher and Jeffrey N. Weitzel

increased susceptibility to cancer as the result of 1 or more gene mutations present in parental germline cells; cancers developing in these individuals may be classified as hereditary or familial cancers. Hereditary cancers are often characterized by

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Presenters : Robert Pilarski, Jennifer M. Weiss, Susan M. Domchek and Moderated by Tuya Pal

role of moderate-penetrance genes in defining risks for hereditary cancer, and the controversies associated with direct-to-consumer genetic testing services. Promises and Problems of Multigene Panel Testing Genetic testing options have changed

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Kaylene Ready and Banu Arun

cancer to determine a woman's breast cancer risk. The purpose of the guidelines is to identify women with a hereditary form of breast cancer, and to identify those without hereditary forms but who are still at increased risk based on a family history of

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Julia R. Trosman, Christine B. Weldon, Michael P. Douglas, Allison W. Kurian, R. Kate Kelley, Patricia A. Deverka and Kathryn A. Phillips

Background Identification of hereditary cancer predisposition is an important component of cancer risk management, prevention, and treatment. 1 – 3 Its significance was underscored recently by President Obama's Precision Medicine Initiative