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Role of Interventional Radiology in the Treatment of Patients with Neuroendocrine Metastases in the Liver

Larry K. Kvols, Kiran K. Turaga, Jonathan Strosberg, and Junsung Choi

tumors and islet cell carcinomas . Ann Intern Med 1994 ; 120 : 302 – 309 . 2 Carrasco CH Charnsangavej C Ajani J . The carcinoid syndrome: palliation by hepatic artery embolization . AJR Am J Roentgenol 1986 ; 147 : 149 – 154 . 3

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Metastatic Insulinoma: Current Molecular and Cytotoxic Therapeutic Approaches for Metastatic Well-Differentiated panNETs

Iulia Giuroiu and Diane Reidy-Lagunes

cancer continued to progress and the patient was found comatose at his home twice, with severe hypoglycemic shock; both times he recovered only after his wife administered glucagon injections. After another round of hepatic artery embolization, the

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Novel Treatment Options for Neuroendocrine Tumors

Matthew H. Kulke

-predominant disease may benefit from hepatic-directed therapy. Recommended liver-directed therapies for patients with liver-predominant disease include hepatic resection and hepatic artery embolization (unresectable disease). Liver transplantation is only considered

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Liver-Directed Therapies in Patients With Advanced Neuroendocrine Tumors

Natalie B. Jones, Manisha H. Shah, and Mark Bloomston

other interventional therapies or best medical supportive care. In addition to Yao et al., 13 Chamberlain et al. 21 compared surgical resection with hepatic artery embolization and medical therapy in a group of 85 patients, 38 of whom had extrahepatic

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Systemic Therapy for Advanced Carcinoid Tumors: Where Do We Go From Here?

A. Scott Paulson and Emily K. Bergsland

Kulke MH Benson AB III Bergsland E . NCCN Clinical Practice Guidelines in Oncology: Neuroendocrine Tumors. Version 1 , 2012 . Available at: NCCN.org . Accessed March 27, 2012 . 15 Gupta S Yao JC Ahrar K . Hepatic artery embolization and

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NCCN Guidelines Insights: Hepatobiliary Cancers, Version 1.2017

Al B. Benson III, Michael I. D'Angelica, Daniel E. Abbott, Thomas A. Abrams, Steven R. Alberts, Daniel A. Anaya, Chandrakanth Are, Daniel B. Brown, Daniel T. Chang, Anne M. Covey, William Hawkins, Renuka Iyer, Rojymon Jacob, Andrea Karachristos, R. Kate Kelley, Robin Kim, Manisha Palta, James O. Park, Vaibhav Sahai, Tracey Schefter, Carl Schmidt, Jason K. Sicklick, Gagandeep Singh, Davendra Sohal, Stacey Stein, G. Gary Tian, Jean-Nicolas Vauthey, Alan P. Venook, Andrew X. Zhu, Karin G. Hoffmann, and Susan Darlow

Do RK Gonen M . Randomized trial of hepatic artery embolization for hepatocellular carcinoma using doxorubicin-eluting microspheres compared with embolization with microspheres alone . J Clin Oncol 2016 ; 34 : 2046 – 2053 . 71. Ibrahim

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NCCN Guidelines Insights: Older Adult Oncology, Version 2.2016

Noam VanderWalde, Reshma Jagsi, Efrat Dotan, Joel Baumgartner, Ilene S. Browner, Peggy Burhenn, Harvey Jay Cohen, Barish H. Edil, Beatrice Edwards, Martine Extermann, Apar Kishor P. Ganti, Cary Gross, Joleen Hubbard, Nancy L. Keating, Beatriz Korc-Grodzicki, June M. McKoy, Bruno C. Medeiros, Ewa Mrozek, Tracey O'Connor, Hope S. Rugo, Randall W. Rupper, Dale Shepard, Rebecca A. Silliman, Derek L. Stirewalt, William P. Tew, Louise C. Walter, Tanya Wildes, Mary Anne Bergman, Hema Sundar, and Arti Hurria

comparison of outcomes from treating hepatocellular carcinoma by hepatic artery embolization in patients younger or older than 70 years . Cancer 2009 ; 115 : 5000 – 5006 . 33. Mirici-Cappa F Gramenzi A Santi V . Treatments for hepatocellular

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NCCN Task Force Report: Update on the Management of Patients with Gastrointestinal Stromal Tumors

George D. Demetri, Margaret von Mehren, Cristina R. Antonescu, Ronald P. DeMatteo, Kristen N. Ganjoo, Robert G. Maki, Peter W.T. Pisters, Chandrajit P. Raut, Richard F. Riedel, Scott Schuetze, Hema M. Sundar, Jonathan C. Trent, and Jeffrey D. Wayne

metastases are commonly distributed in both lobes, often precluding standard hepatectomies for complete resection. Radiofrequency ablation (RFA), hepatic artery embolization, and liver transplantation are other alternative options for treating liver

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Neuroendocrine Tumors

Matthew H. Kulke, Al B. Benson III, Emily Bergsland, Jordan D. Berlin, Lawrence S. Blaszkowsky, Michael A. Choti, Orlo H. Clark, Gerard M. Doherty, James Eason, Lyska Emerson, Paul F. Engstrom, Whitney S. Goldner, Martin J. Heslin, Fouad Kandeel, Pamela L. Kunz, Boris W. Kuvshinoff II, Jeffrey F. Moley, Venu G. Pillarisetty, Leonard Saltz, David E. Schteingart, Manisha H. Shah, Stephen Shibata, Jonathan R. Strosberg, Jean-Nicolas Vauthey, Rebekah White, James C. Yao, Deborah A. Freedman-Cass, and Mary A. Dwyer

hepatic artery embolization for metastatic neuroendocrine tumors [abstract] . J Clin Oncol 2011 ; 29 ( Suppl 4 ): Abstract 244 . 116 Perry LJ Stuart K Stokes KR Clouse ME . Hepatic arterial chemoembolization for metastatic neuroendocrine

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NCCN Task Force Report: Management of Patients with Gastrointestinal Stromal Tumor (GIST)—Update of the NCCN Clinical Practice Guidelines

George D. Demetri, Robert S. Benjamin, Charles D. Blanke, Jean-Yves Blay, Paolo Casali, Haesun Choi, Christopher L. Corless, Maria Debiec-Rychter, Ronald P. DeMatteo, David S. Ettinger, George A. Fisher, Christopher D. M. Fletcher, Alessandro Gronchi, Peter Hohenberger, Miranda Hughes, Heikki Joensuu, Ian Judson, Axel Le Cesne, Robert G. Maki, Michael Morse, Alberto S. Pappo, Peter W. T. Pisters, Chandrajit P. Raut, Peter Reichardt, Douglas S. Tyler, Annick D. Van den Abbeele, Margaret von Mehren, Jeffrey D. Wayne, and John Zalcberg

liver resection may be required. 60 , 102 Percutaneous ablation of liver lesions less than 5 cm in size may also be considered. For bulkier disease, hepatic artery embolization should be considered. 104 , 105 An unresolved issue is how long to keep