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Jill Corre and Hervé Avet-Loiseau

overexpression of positive regulators of the nuclear factor κB (NF-κB) pathway. DNA-based techniques, such as array comparative genomic hybridization, 12 , 13 have identified the role of the NF-κB pathway in myeloma. Two separate studies have shown that the NF

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Yvonne Bombard, Peter B. Bach and Kenneth Offit

Genomics in Cancer Care There is increasing enthusiasm for genomics and its promise in advancing personalized medicine. 1 - 3 However, the application of genomics in health care is not a novel concept. Genetic testing and risk assessment

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Stefanie S. Jeffrey, Per Eystein Lønning and Bruce E. Hillner

tumor cells and normal ductal epithelial cells selected for purity by laser microdissection . Oncogene 2004 ; 23 : 2385 – 2400 . 67 Weiss MM Kuipers EJ Postma C . Genomic profiling of gastric cancer predicts lymph node status and survival

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Céline Mascaux, Ming-Sound Tsao and Fred R. Hirsch

In the current era of cancer therapy, genomic testing of tumor samples and, more recently, blood, allows for the selection of patients most likely to derive benefit from certain treatments with reduced toxicity, and helps avoid unnecessary

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Matthew Ellis

Deep genomic analysis of breast cancer tumors should soon result in new therapeutic road maps, with treatment paradigms based on a pharmacopeia of cell-type and pathway-matched therapies. Individual cases of breast cancer will ultimately be

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Wing C. Chan and James O. Armitage

direction in drug development, and shown the potential to improve treatment outcome by directing choice of therapy. Methods of Genomic Analysis Gene expression profiling studies can be performed using various techniques, but the most widely used has

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Rajmohan Murali, Deborah F. Delair, Sarah M. Bean, Nadeem R. Abu-Rustum and Robert A. Soslow

-Genetic Classification The Cancer Genome Atlas (TCGA) study of endometrioid and serous carcinomas found mutations in several genes (eg, TP53, PTEN, PIK3CA, PPP2R1A, FBXW7, CTNNB1, KRAS , and POLE ) and, more importantly, identified 4 major genomically defined classes

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Rishi Jain, Michelle J. Savage, Andrea D. Forman, Reetu Mukherji and Michael J. Hall

of next-generation sequencing (NGS)–based multigene somatic or tumor tests in the outpatient clinic portends an urgent need for oncologists to evaluate how new genetic/genomic tests are integrated into the care of patients with cancer. Traditional

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Deborah J. MacDonald, Kathleen R. Blazer and Jeffrey N. Weitzel

R apidly evolving genetic and genomic technologies for genetic cancer risk assessment (GCRA) are revolutionizing the approach to targeted therapy and cancer screening and prevention, heralding the era of personalized medicine. Although academic

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Katy K. Tsai, Neharika Khurana, Timothy McCalmont, Adil Daud, Boris Bastian and Iwei Yeh

therapeutic options. A formalin-fixed, paraffin-embedded tumor sample was submitted to Foundation Medicine for comprehensive genomic profiling. FoundationOne is a next-generation sequencing–based assay developed and validated to identify genomic alterations