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Mary B. Daly, Jennifer E. Axilbund, Saundra Buys, Beth Crawford, Carolyn D. Farrell, Susan Friedman, Judy E. Garber, Salil Goorha, Stephen B. Gruber, Heather Hampel, Virginia Kaklamani, Wendy Kohlmann, Allison Kurian, Jennifer Litton, P. Kelly Marcom, Robert Nussbaum, Kenneth Offit, Tuya Pal, Boris Pasche, Robert Pilarski, Gwen Reiser, Kristen Mahoney Shannon, Jeffrey R. Smith, Elizabeth Swisher and Jeffrey N. Weitzel

Assessment Cancer genetic risk assessment and genetic counseling is a multistep process of identifying and counseling individuals at risk for familial or hereditary cancer. Cancer genetic risk assessment involves use of pedigree analysis with available

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Kaylene Ready and Banu Arun

become familiar with its process. Cancer Genetic Risk Assessment To better understand how to manage patients who have an increased risk of breast cancer based on family history, a basic understanding of the process of cancer genetic risk

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Wylie Burke and Nancy Press

screening with MRI—what are the data for patients at high risk? N Engl J Med 2004 ; 351 : 497 – 500 . 11. Nelson HD Huffman LH Fu R Harris EL . Genetic risk assessment and BRCA mutation testing for breast and ovarian cancer susceptibility

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Tarra Evans and Ursula Matulonis

Clinical Implications Genetic Risk Assessment During the past decade, NGS panels of genes associated with gynecologic malignancies have become important tools in counseling patients and families concerning cancer risk, risk-reduction planning, and

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Peter R. Carroll, J. Kellogg Parsons, Gerald Andriole, Robert R. Bahnson, Erik P. Castle, William J. Catalona, Douglas M. Dahl, John W. Davis, Jonathan I. Epstein, Ruth B. Etzioni, Thomas Farrington, George P. Hemstreet III, Mark H. Kawachi, Simon Kim, Paul H. Lange, Kevin R. Loughlin, William Lowrance, Paul Maroni, James Mohler, Todd M. Morgan, Kelvin A. Moses, Robert B. Nadler, Michael Poch, Chuck Scales, Terrence M. Shaneyfelt, Marc C. Smaldone, Geoffrey Sonn, Preston Sprenkle, Andrew J. Vickers, Robert Wake, Dorothy A. Shead and Deborah A. Freedman-Cass

gene. 64 – 68 The panel received an external submission requesting that genetic risk assessment be recommended in the NCCN Guidelines for Prostate Cancer Early Detection based on recommendations in the NCCN Guidelines for Genetic/Familial High

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Brandie Heald, Shanna Gustafson, Jessica Mester, Patricia Arscott, Katherine Lynch, Jessica Moline and Charis Eng

8000 patients at these centers would need to undergo a genetic risk assessment and, potentially, genetic testing in the setting of genetic counseling. Using the data from this study, a GCO model would be 30% more efficient than a GC/MD seeing this

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Michael J. Hall

. Guidelines for genetic risk assessment of hereditary breast and ovarian cancer: early disagreements and low utilization . J Gen Intern Med 2009 ; 24 : 822 – 828 . 26. Lerman C Hughes C Croyle RT . Prophylactic surgery decisions and surveillance

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Heather H. Cheng, Alexandra O. Sokolova, Edward M. Schaeffer, Eric J. Small and Celestia S. Higano

), referral to a genetic counselor for dedicated, confirmatory germline testing is indicated. Family and Personal History of Cancer Family history of cancer remains a foundation of genetic risk assessment, and inquiring about prostate and nonprostate cancers

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Deborah J. MacDonald, Kathleen R. Blazer and Jeffrey N. Weitzel

Genet Couns 2006 ; 15 : 505 – 514 . 32. Lagos VI Perez MA Ricker CN . Social cognitive aspects of underserved Latinas preparing to undergo genetic risk assessment for hereditary breast and ovarian cancer . Psychooncology 2008 ; 17 : 774

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Elizabeth A. Nardi, Julie A. Wolfson, Steven T. Rosen, Robert B. Diasio, Stanton L. Gerson, Barbara A. Parker, Joseph C. Alvarnas, Harlan A. Levine, Yuman Fong, Dennis D. Weisenburger, C. Lyn Fitzgerald, Maggie Egan, Sharon Stranford, Robert W. Carlson and Edward J. Benz Jr

surgery, oncology radiation, pathology, radiology, tumor boards, integrated subspecialty multidisciplinary care, novel therapeutics and clinical trials, experienced nursing, support staff, rehabilitation services, genetic risk assessment for early