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Margaret L. McNeely and Kerry S. Courneya

O ver the past decade, a significant increase has occurred in the amount and quality of research examining the role of exercise in managing cancer-related fatigue (CRF). 1 – 5 In fact, a recent systematic review noted that CRF is the most

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William Breitbart and Yesne Alici

S everal pharmacologic agents have been considered and studied for the treatment of cancer-related fatigue, including psychostimulants, antidepressants, megestrol acetate, and amantadine. 1 A recent meta-analysis of pharmacologic treatment

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Joanne E. Mortimer, Andrea M. Barsevick, Charles L. Bennett, Ann M. Berger, Charles Cleeland, Shannon R. DeVader, Carmen Escalante, Jeffrey Gilreath, Arti Hurria, Tito R. Mendoza, and Hope S. Rugo

T he NCCN Cancer-Related Fatigue (CRF) Scientific Research Committee was convened in September 2009 to accomplish 3 objectives: 1) review the current methods to measure and interventions to treat CRF; 2) recommend a CRF measure or develop a new

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Ann M. Berger, Amy Pickar Abernethy, Ashley Atkinson, Andrea M. Barsevick, William S. Breitbart, David Cella, Bernadine Cimprich, Charles Cleeland, Mario A. Eisenberger, Carmen P. Escalante, Paul B. Jacobsen, Phyllis Kaldor, Jennifer A. Ligibel, Barbara A. Murphy, Tracey O'Connor, William F. Pirl, Eve Rodler, Hope S. Rugo, Jay Thomas, and Lynne I. Wagner

Overview Fatigue is a common symptom in patients with cancer and is nearly universal in those undergoing cytotoxic chemotherapy, radiation therapy, bone marrow transplantation, or treatment with biologic response modifiers. 1 – 10 The symptom

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Ann M. Berger, Kathi Mooney, Amy Alvarez-Perez, William S. Breitbart, Kristen M. Carpenter, David Cella, Charles Cleeland, Efrat Dotan, Mario A. Eisenberger, Carmen P. Escalante, Paul B. Jacobsen, Catherine Jankowski, Thomas LeBlanc, Jennifer A. Ligibel, Elizabeth Trice Loggers, Belinda Mandrell, Barbara A. Murphy, Oxana Palesh, William F. Pirl, Steven C. Plaxe, Michelle B. Riba, Hope S. Rugo, Carolina Salvador, Lynne I. Wagner, Nina D. Wagner-Johnston, Finly J. Zachariah, Mary Anne Bergman, and Courtney Smith

Fatigue is a common symptom in patients with cancer. It is nearly universal in those receiving cytotoxic chemotherapy, radiation therapy, bone marrow transplantation, or treatment with biologic response modifiers. 1 – 3 According to a survey of 1569

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Carmen P. Escalante, Ellen Manzullo, and Rosalie Valdres

The authors receive grant funding from Ortho Biotech Oncology. References 1 Mock V Atkinson A Barsevick A NCCN cancer-related fatigue clinical practice guidelines in oncology . Oncology 2000 ; 14 : 151 – 161 . 2

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Ilana M. Braun, Donna B. Greenberg, and William F. Pirl

The authors have no financial interest, arrangement, or affiliation with the manufacturers of any products discussed in the article or their competitors. References 1. Spelton ER Verbeek JH Uitterhoeve AL . Cancer, fatigue

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Zeeshan Butt, Sarah K. Rosenbloom, Amy P. Abernethy, Jennifer L. Beaumont, Diane Paul, Debra Hampton, Paul B. Jacobsen, Karen L. Syrjala, Jamie H. Von Roenn, and David Cella

. The functional assessment of cancer therapy scale: development and validation of the general measure . J Clin Oncol 1993 ; 11 : 570 – 579 . 2. Winningham ML Nail LM Burke MB . Fatigue and the cancer experience: the state of the knowledge

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William Breitbart and Yesne Alici-Evcimen

. Curt GA Breitbart W Cella D . Impact of cancer-related fatigue on the lives of patients: new findings from the Fatigue Coalition . Oncologist 2000 ; 5 : 353 – 360 . 2. Hwang SS Chang VT Rue M Kasimis B . Multidimensional independent

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Ann Malone Berger and Sandra A. Mitchell

The authors have no financial interest, arrangement, or affiliation with the manufacturers of any products discussed in the article or their competitors. References 1. Prue G Rankin J Allen J . Cancer-related fatigue: a