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Diagnosis and Management of Rectal Cancer in Patients Younger Than 50 Years: Rising Global Incidence and Unique Challenges

Daenielle Lang and Kristen K. Ciombor

This review focuses specifically on early-onset rectal cancer [EORC] and explores (1) epidemiologic trends; (2) characteristics, including presentation, staging, and histologic and molecular features; (3) treatment, including recent and ongoing trials