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Donna Trauth and Lori J. Goldstein

. 16 Sparreboom A van Tellingen O Nooijen WJ . Preclinical pharmacokinetics of paclita el and docetaxel . Anticancer Drugs 1998 ; 9 : 1 – 17 . 17 Bruno R Hille D Riva A . Population pharmacokinetics/pharmacodynamics of docetaxel in

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Wei Nie, Jie Qian, Mi-Die Xu, Kai Gu, Fang-Fei Qian, Jun Lu, Xue-Yan Zhang, Hui-Min Wang, Bo Yan, Bo Zhang, Shu-Yuan Wang, Fang Hu, Chang-Hui Li, Hua Zhong, and Bao-Hui Han

POPLAR trials has been described previously. 8 , 10 , 11 Patients who had previously received chemotherapy for stage IIIB or IV NSCLC were randomized (1:1) to treatment with atezolizumab (1,200 mg fixed dose) or docetaxel (75 mg/m 2 ). Because the aim of

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Baijun Dong, Liancheng Fan, Bin Yang, Wei Chen, Yonghong Li, Kaijie Wu, Fengbo Zhang, Haiying Dong, Huihua Cheng, Jiahua Pan, Yinjie Zhu, Chenfei Chi, Liang Dong, Jianjun Sha, Lei Li, Xudong Yao, and Wei Xue

.5%), respectively. Patients were also categorized according to treatment after blood collection. Baseline sample numbers from those receiving treatment (after baseline ctDNA collection) were as follows: abiraterone (n=58), docetaxel (n=66), platinum

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Alberto Carmona-Bayonas, Paula Jiménez-Fonseca, Maria Luisa Sánchez Lorenzo, Avinash Ramchandani, Elena Asensio Martínez, Ana Custodio, Marcelo Garrido, Isabel Echavarría, Juana María Cano, Jose Enrique Lorenzo Barreto, Teresa García García, Felipe Álvarez Manceñido, Alejandra Lacalle, Marta Ferrer Cardona, Monserrat Mangas, Laura Visa, Elvira Buxó, Aitor Azkarate, Asunción Díaz-Serrano, Ana Fernández Montes, and Fernando Rivera

treatment for patients with AGC. 5 In the V325 randomized clinical trial (RCT), the DCF (docetaxel, cisplatin, fluorouracil) regimen was superior to CF (cisplatin, fluorouracil) in patients with a good performance status (PS) and preserved organ function

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Zachary Veitch, Omar F. Khan, Derek Tilley, Domen Ribnikar, Xanthoula Kostaras, Karen King, Patricia Tang, and Sasha Lupichuk

is well described. 8 – 11 However, the potential for overtreatment and toxicity associated with use of third-generation chemotherapy regimens is of concern. After the E1199 clinical trial 12 established the equivalence of docetaxel every 3 weeks and

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Vivek Subbiah, Ulka Vaishampayan, Sonam Puri, Lanjia Lin, Mark Chao, Giri Ramsingh, Shivaani Kummar, James F Strauss, and Sandip P Patel

signals on tumor cells, leading to synergistic antitumor activity when combined with magrolimab. This study ( NCT04827576 ) evaluates the safety, tolerability, and efficacy of magrolimab with docetaxel in relapsed/refractory metastatic urothelial cancer

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Dawn Goetz

/mL but then sharply increased to 35 ng/mL in February 2010. Imaging showed increased bony metastases and new lymph node involvement. The patient was then started on docetaxel, 75 mg/m 2 , with prednisone every 3 weeks and continued therapy with

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Nicolas Batty, Naveen Yarlagadda, and Roberto Pili

docetaxel at 75 mg/m 2 and prednisone and completed 13 cycles with clinical benefit. This treatment was followed by a short drug holiday. Unfortunately, restaging CT revealed new liver lesions. A second line of chemotherapy with cabazitaxel was then

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Zachary Veitch, Omar F. Khan, Derek Tilley, Patricia A. Tang, Domen Ribnikar, Douglas A. Stewart, Xanthoula Kostaras, Karen King, and Sasha Lupichuk

Evaluation of docetaxel dose reductions have also yielded conflicting results. 20 , 21 Currently, a paucity of data exists for dose adjustments affecting survival for third-generation anthracycline/taxane-based regimens. Furthermore, for sequential regimens

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Komal Jhaveri and Francisco J. Esteva

and docetaxel in a phase Ib trial. 25 One patient with prostate cancer experienced a partial response and more than 50% of patients experienced SD after 4 cycles of treatment with combination therapy. DLTs of grade 3 diarrhea and grade 4 febrile