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Eleni Linos and Walter C. Willett

Dowsett M . Influences on circulating oestrogens in postmenopausal women: relationship with breast cancer . J Steroid Biochem Mol Biol 2007 ; 103 : 99 – 109 . 4. Linos E Holmes MD Willett WC . Diet and breast cancer . Curr Oncol Rep 2007

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Mamta Mehta and Moshe Shike

diet may be important. To add to the complexity, it is clear that genetic-environmental interactions may ultimately determine the effects of genetic, nutritional, or environmental factors. Most studies on diet and cancer have analyzed data with little

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Willemieke P.M. Dijksterhuis, Anouk E.J. Latenstein, Jessy Joy van Kleef, Rob H.A. Verhoeven, Jeanne H.M. de Vries, Marije Slingerland, Elles Steenhagen, Joos Heisterkamp, Liesbeth M. Timmermans, Marian A.E. de van der Schueren, Martijn G.H. van Oijen, Sandra Beijer, and Hanneke W.M. van Laarhoven

or a high risk of malnutrition, measures should be taken to improve the nutritional status. 2 , 25 , 26 These measures usually consist of dietetic consultation to promote a personalized diet high in energy and proteins, supplemented by the use of

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Adam L. Cohen and John H. Ward

, investigators must extrapolate from studies of invasive breast cancer. Two studies have examined the effect of diet on recurrence of early-stage breast cancer. The Women's Healthy Eating and Living (WHEL) study randomized 3088 women to a standard diet or an

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Yuan-Yuan Lei, Suzanne C. Ho, Ashley Cheng, Carol Kwok, Chi-Kiu Iris Lee, Ka Li Cheung, Roselle Lee, Herbert H.F. Loong, Yi-Qian He, and Winnie Yeo

maintaining normal body weight, being physically active, and eating a healthy diet, are individually associated with better HRQoL among breast cancer survivors. 6 – 8 A cancer diagnosis has been considered as a “teachable moment,” wherein survivors are likely

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Carlo C. Maley and Anil K. Rustgi

esophagus and gastric cardia . J Natl Cancer Inst 1997 ; 89 : 1277 – 1284 . 72. Kabat GC Ng SK Wynder EL . Tobacco, alcohol intake, and diet in relation to adenocarcinoma of the esophagus and gastric cardia . Cancer Causes Control 1993 ; 4

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Gabrielle B. Rocque, Richard A. Taylor, Aras Acemgil, Xuelin Li, Maria Pisu, Kelly Kenzik, Bradford E. Jackson, Karina I. Halilova, Wendy Demark-Wahnefried, Karen Meneses, Yufeng Li, Michelle Y. Martin, Carol Chambless, Nedra Lisovicz, Mona Fouad, Edward E. Partridge, Elizabeth A. Kvale, and the Patient Care Connect Group

, only 46.3% of individuals reporting pain also requested assistance for pain. Patients were most likely to ask for help with questions about insurance/financial needs (79.1%), transportation (75.5%), and knowledge deficits about diet/nutrition (75

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J. Sybil Biermann, Warren Chow, Damon R. Reed, David Lucas, Douglas R. Adkins, Mark Agulnik, Robert S. Benjamin, Brian Brigman, G. Thomas Budd, William T. Curry, Aarati Didwania, Nicola Fabbri, Francis J. Hornicek, Joseph B. Kuechle, Dieter Lindskog, Joel Mayerson, Sean V. McGarry, Lynn Million, Carol D. Morris, Sujana Movva, Richard J. O'Donnell, R. Lor Randall, Peter Rose, Victor M. Santana, Robert L. Satcher, Herbert Schwartz, Herrick J. Siegel, Katherine Thornton, Victor Villalobos, Mary Anne Bergman, and Jillian L. Scavone

The NCCN Guidelines for Bone Cancer provide interdisciplinary recommendations for treating chordoma, chondrosarcoma, giant cell tumor of bone, Ewing sarcoma, and osteosarcoma. These NCCN Guidelines Insights summarize the NCCN Bone Cancer Panel's guideline recommendations for treating Ewing sarcoma. The data underlying these treatment recommendations are also discussed.

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Sofia D. Merajver and Kara Milliron

Breast cancer, a complex and heterogeneous disease, is the most common malignancy diagnosed in women in the United States, with over 180,000 new cases and approximately 44,000 deaths per year. Breast cancer risk is influenced by a large number of factors, including age, family history, reproductive and hormonal history, proliferative breast conditions, physical activity, diet, and environmental exposures. These factors all interact in a complex manner to contribute to the risk of developing breast cancer. Because the interactions between risk factors are poorly understood at the molecular level, it is difficult to accurately evaluate the breast cancer risk of a given person presenting with an individual constellation of factors. To better define the population at increased risk that may warrant specific intervention, several models exist to estimate a woman's risk for developing breast cancer and for harboring a germline mutation in a cancer susceptibility gene. This article summarizes these models and gives brief guidelines about which model may be preferable given a specific family history.

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Paul F. Engstrom