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Alex J. Mitchell

health-related quality of life, 4 poor satisfaction with medical care, 5 and possibly reduced survival. 6 Early psychometric research focused on diagnostic accuracy (performance against another scale) and diagnostic validity (performance against a true

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Patricia Ellen Goldhoff, Poonam Vohra, Kanti Pallav Kolli and Britt-Marie Ljung

biopsy (FNAB) inferior to those from core needle biopsy (CNB). Conflicting data in the literature have also led to confusion. A recent study of 74 paired FNABs and CNBs of liver masses showed FNAB to have superior diagnostic accuracy in metastatic lesions

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Amy Ly, Jill C. Ono, Kevin S. Hughes, Martha B. Pitman and Ronald Balassanian

hypothesized that FNAB is able to provide patients their breast biopsy diagnoses in a more timely fashion than core biopsy, without compromising diagnostic accuracy. Although the American College of Surgeons and National Accreditation Program for Breast Centers

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George D. Demetri, Margaret von Mehren, Cristina R. Antonescu, Ronald P. DeMatteo, Kristen N. Ganjoo, Robert G. Maki, Peter W.T. Pisters, Chandrajit P. Raut, Richard F. Riedel, Scott Schuetze, Hema M. Sundar, Jonathan C. Trent and Jeffrey D. Wayne

The standard of care for managing patients with gastrointestinal stromal tumors (GISTs) rapidly changed after the introduction of effective molecularly targeted therapies involving tyrosine kinase inhibitors (TKIs), such as imatinib mesylate and sunitinib malate. A better understanding of the molecular characteristics of GISTs have improved the diagnostic accuracy and led to the discovery of novel immunomarkers and new mechanisms of resistance to TKI therapy, which in turn have resulted in the development of novel treatment strategies. To address these issues, the NCCN organized a task force consisting of a multidisciplinary panel of experts in the fields of medical oncology, surgical oncology, molecular diagnostics, and pathology to discuss the recent advances, identify areas of future research, and recommend an optimal approach to care for patients with GIST at all stages of disease. The task force met for the first time in October 2003 and again in December 2006 and October 2009. This supplement describes the recent developments in the field of GIST as discussed at the October 2009 meeting.

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Estanislao Arana, Francisco M. Kovacs, Ana Royuela, Beatriz Asenjo, Fatima Nagib, Sandra Pérez-Aguilera, María Dejoz, Alberto Cabrera-Zubizarreta, Yolanda García-Hidalgo, Ana Estremera and for the Spanish Back Pain Research Network Task Force for the Improvement of Inter-Disciplinary Management of Spinal Metastasis

.21–0.40), “slight” (0.00–0.20), or “poor” (<0.00) agreement. 8 The association between the diagnosis (MVF vs OVF) before and after readers were aware of a patient’s cancer history was based on the assessments made during the first round. Diagnostic accuracy was

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Brian P. Rubin and John R. Goldblum

; 11 : 24 – 37 . 2. Yang YJ Damron TA . Comparison of needle core biopsy and fine-needle aspiration for diagnostic accuracy in musculoskeletal lesions . Arch Pathol Lab Med 2004 ; 128 : 759 – 764 . 3. Hoeber I Spillane AJ

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Donald A. Podoloff

tomography using fluorodeoxyglucose in patients with metastases of unknown primary tumors (CUP syndrome) . Nucl Med Commun 2003 ; 24 : 1081 – 1086 . 18 Fencl P Belohlavek O Skopalova M . Prognostic and diagnostic accuracy of [18F]FDG-PET/CT in

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Christopher Gilbert, Lonny Yarmus and David Feller-Kopman

on EBUS-TBNA. When compared with surgical resection with mediastinal lymphadenectomy, EBUS-TBNA showed a sensitivity and specificity of 92.3% and 100% with a positive predictive value, negative predictive value, and diagnostic accuracy of 100%, 97

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Joseph J. Fantony and Brant A. Inman

. Replacement for Cystoscopy For a urine test to replace cystoscopy as the gold standard for detecting bladder cancer, it must be superior to cystoscopy in at least 1 of 3 ways: cost, diagnostic accuracy, and/or invasiveness. With respect to cost, cytology and

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Benjamin O. Anderson

and CB had similar diagnostic accuracy and rates of diagnostic discordance that warranted additional sampling. No false-positive or false-negative diagnoses occurred with either biopsy method. The investigators point out that waiting time for