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Christina A. Minami and Karl Y. Bilimoria

-world conditions. In principle, comparative effectiveness research (CER) is not a new idea; the Institute of Medicine broadly defines it as the synthesis of evidence that compares the benefits and harms of alternative methods to prevent, diagnose, treat, and

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Nora Janjan

NIH funding of the burden of illness research increased from $56 million to $74 million over the same period. Meanwhile, more than $500 million was allocated to the funding of comparative effectiveness research (CER), which is twice that spent on

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Edward C. Li and Jessica DeMartino

programmatic administration. As part of this legislation, a Federal Coordinating Council for Comparative Effectiveness Research (FCCCER) was established to “coordinate and guide research investments in comparative effectiveness research funded by the Recovery

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Michael A. Kolodziej

have been involved in discussions and debates surrounding many of these contentious issues, from reimbursement reform to Centers for Medicare & Medicaid (CMS) and FDA policy to comparative effectiveness research. I have been frustrated by my perception

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Catherine Lockhart, Cara McDermott, James Marshall, Aaron Mendelsohn, Pamala Pawloski and Jeffrey Brown

. Objective: To evaluate patient characteristics and treatment use patterns in patients treated with GCSFs. This analysis will help inform a large-scale, real-world, observational GCSF comparative effectiveness research (CER) study using the Biologics

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12 1576 1576 1583 1583 jnccn0131576 10.6004/jnccn.2015.0183 Databases as Vehicles for Comparative Effectiveness Research Minami Christina A. MD Bilimoria Karl Y. MD, MS 12 2015 13 13 12 12 1585 1585 1588 1588 0131585 10.6004/jnccn

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David C. Hohn

-level evidence does not exist. To address this deficit, the PPACA has already established a new agency, the Patient-Centered Outcomes Research Institute (PCORI), to guide and administer comparative effectiveness research (CER) grants “to assist consumers

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Shane Lloyd, Daniela L. Buscariollo, Cary P. Gross, Danil V. Makarov and James B. Yu

are currently underway to better summarize the comparative effectiveness research available to guide physicians in treatment selection. 15 - 18 This study should be interpreted with the understanding that using the number or percentage of C1

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Michaela A. Dinan, Bradford R. Hirsch and Gary H. Lyman

Given the inherent complexity of defining and measuring quality of care and costs in clinical oncology and how these in turn define value, comparative effectiveness research (CER) is needed to help with the discussion of value in cancer care. 3 , 17 The

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Bradford R. Hirsch and Amy P. Abernethy

information on a patient’s pain, quality of life, and distress. It can be linked to administrative databases, electronic health records, clinical research datasets, and basic science research to enhance quality monitoring, comparative effectiveness research