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Laura M. Kulik

; 45 : 1206 – 1213 . 11. De Mitri MS Poussin K Baccarini P . HCV-associated liver cancer without cirrhosis . Lancet 1995 ; 345 : 413 – 415 . 12. Bralet MP Regimbeau JM Pineau P . Hepatocellular carcinoma occurring in

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Ghassan K. Abou-Alfa

. Lancet 1978 ; 1 : 1006 – 1009 . 12 Williams R Melia WM . Liver tumours and their management . Clin Radiol 1980 ; 31 : 1 – 11 . 13 Barbare JC Ballet F Petit J . [Hepatocellular carcinoma with cirrhosis: treatment with

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Al B. Benson III, Thomas A. Abrams, Edgar Ben-Josef, P. Mark Bloomston, Jean F. Botha, Bryan M. Clary, Anne Covey, Steven A. Curley, Michael I. D'Angelica, Rene Davila, William D. Ensminger, John F. Gibbs, Daniel Laheru, Mokenge P. Malafa, Jorge Marrero, Steven G. Meranze, Sean J. Mulvihill, James O. Park, James A. Posey, Jasgit Sachdev, Riad Salem, Elin R. Sigurdson, Constantinos Sofocleous, Jean-Nicolas Vauthey, Alan P. Venook, Laura Williams Goff, Yun Yen and Andrew X. Zhu

– 96 . 2 Fattovich G Stroffolini T Zagni I Donato F . Hepatocellular carcinoma in cirrhosis: incidence and risk factors . Gastroenterology 2004 ; 127 ( 5 Suppl 1 ): S35 – 50 . 3 Bosch FX Ribes J Borras J . Epidemiology of

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Harrys A. Torres, Parag Mahale, Boris Blechacz, Ethan Miller, Ahmed Kaseb, H. Franklin Herlong, Nathan Fowler, Ying Jiang, Issam I. Raad and Dimitrios P. Kontoyiannis

cancer treatment complicated. 16 In addition, successful HCV therapy can cure HCV, prevent its reactivation, 17 delay progression to cirrhosis, 12 – 14 and improve overall mortality rates, as observed in the general population of HCV-monoinfected and

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Amit G. Singal, Jorge A. Marrero and Adam Yopp

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide and one of the leading causes of death among patients with cirrhosis. It has an increasing incidence in the United States because of the current epidemics

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Jean F. Botha and Alan N. Langnas

hepatocellular carcinoma in cirrhotic patients . Ann Surg 1993 ; 218 : 145 – 151 . 8. Mazzaferro V Regalia E Doci R . Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis . N Engl J Med 1996 ; 334

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Anne M. Covey

areas, development of cirrhosis in patients who were infected with hepatitis C virus (HCV) in the 1970s and 1980s, as well as the increase in nonalcoholic fatty liver disease. 2 As Dr. Covey pointed out, the incidence of disease parallels that of

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B. Daniel Campos and Jean F. Botha

Edited by Kerrin G. Robinson

cirrhosis . N Eng J Med 1996 ; 334 : 693 – 699 . 8 Jonas S Bechstein WO Steinmuller T . Vascular invasion and histopathologic grading determine outcome after liver transplantation for hepatocellular carcinoma in cirrhosis . Hepatology 2001

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Amit G. Singal, Akbar K. Waljee, Nishant Patel, Emerson Y. Chen, Jasmin A. Tiro, Jorge A. Marrero and Adam C. Yopp

only available for patients diagnosed at an early stage. 2 Surveillance at 6-month intervals is recommended in patients with cirrhosis to detect HCC at an early stage. 3 Despite the availability of efficacious surveillance tests, only 40% of patients

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Hanna K. Sanoff, YunKyung Chang, Joseph M. Stavas, Til Stürmer and Jennifer Lund

cirrhosis and most have multifocal cancer, both of which limit treatment options. 2 , 3 Two intra-arterially delivered locoregional therapy (LRT) options are considered to be reasonable initial therapy for patients with unresectable HCC and compensated