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Beryl McCormick

The 2007 National Comprehensive Cancer Network Breast Cancer Clinical Practice Guidelines in Oncology include a consideration for hyperthermia (HT) and radiation for women with recurrent locoregional advanced breast cancers after first-line surgery or radiation failed. Although HT in this setting has been used for several decades, recent reports are few. This article reviews the data from several recent studies, selected because they included at least 100 patients. Unresolved issues of radiation dose, optimal temperature and timing of HT, and quality assurance problems with thermometry are apparent from these studies. Although clearly an effective treatment option in this clinical scenario, more research on HT and radiation is needed before this treatment combination can be considered standard care.

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Ellen L. Jones, Lawrence B. Marks, and Leonard R. Prosnitz

therapy for the treatment of recurrent cutaneous metastatic breast cancer . Cancer J Sci Am 1998 ; 4 : 378 – 384 . 38. Taber SW Fingar VH Wieman TJ . Photodynamic therapy for palliation of chest wall recurrence in patients with breast cancer

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Gary S. Rogers

response may be a major contributor to the benefits obtained with prolonged light exposure. 11 Figure 2 Chest wall recurrence of breast cancer treated with conventional photodynamic therapy (PDT) versus continuous low-irradiance PDT (CLIPT). With

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Davinia S.E. Seah, Ines Vaz Luis, Erin Macrae, Jessica Sohl, Georgia Litsas, Eric P. Winer, Nancy U. Lin, and Harold J. Burstein

( P =.0011). Chest wall recurrences were noted in 32% of patients with TNBC, compared with 9% and 15% of patients with HR + or HER2-amplified tumors, respectively ( P =.0048). Bone metastases were most common in patients with HR + tumors ( P <.0001

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Prashant Gabani, Emily Merfeld, Amar J. Srivastava, Ashley A. Weiner, Laura L. Ochoa, Dan Mullen, Maria A. Thomas, Julie A. Margenthaler, Amy E. Cyr, Lindsay L. Peterson, Michael J. Naughton, Cynthia Ma, and Imran Zoberi

, available with this article at JNCCN.org ). A total of 21 patients developed LRR, including 5 in-breast recurrences, 11 nodal recurrences, and 11 chest wall recurrences. Of the 11 nodal recurrences, failure occurred in the axilla in 8 patients and in the

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William R. Kennedy, Christopher Tricarico, Prashant Gabani, Ashley A. Weiner, Michael B. Altman, Laura L. Ochoa, Maria A. Thomas, Julie A. Margenthaler, Souzan Sanati, Lindsay L. Peterson, Cynthia X. Ma, Foluso O. Ademuyiwa, and Imran Zoberi

, and 11 chest wall recurrences. Of the nodal recurrences, 8 failed in the axilla, 3 failed in both the axilla and other nodal regions, and no patients had isolated failures in the internal mammary nodes. Figure 1. (A) OS and (B) FFDM by pCR ( P <.001

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Robert W. Carlson, D. Craig Allred, Benjamin O. Anderson, Harold J. Burstein, W. Bradford Carter, Stephen B. Edge, John K. Erban, William B. Farrar, Andres Forero, Sharon Hermes Giordano, Lori J. Goldstein, William J. Gradishar, Daniel F. Hayes, Clifford A. Hudis, Britt-Marie Ljung, David A. Mankoff, P. Kelly Marcom, Ingrid A. Mayer, Beryl McCormick, Lori J. Pierce, Elizabeth C. Reed, Jasgit Sachdev, Mary Lou Smith, George Somlo, John H. Ward, Antonio C. Wolff, and Richard Zellars

randomized trials have compared radiation alone with radiation plus hyperthermia in the treatment of locally advanced/recurrent cancers, primarily breast cancer chest wall recurrences. 276 , 277 Although heterogeneity exists among the study results, a recent