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Brandie Heald, Shanna Gustafson, Jessica Mester, Patricia Arscott, Katherine Lynch, Jessica Moline and Charis Eng

each visit type. Aligned with the greatest reason for referral, hereditary breast-ovarian cancer syndrome (HBOC) from BRCA1 and BRCA2 mutations was the most commonly suspected diagnosis (n=176). GCO visits trended toward seeing significantly more

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Mary B. Daly, Jennifer E. Axilbund, Saundra Buys, Beth Crawford, Carolyn D. Farrell, Susan Friedman, Judy E. Garber, Salil Goorha, Stephen B. Gruber, Heather Hampel, Virginia Kaklamani, Wendy Kohlmann, Allison Kurian, Jennifer Litton, P. Kelly Marcom, Robert Nussbaum, Kenneth Offit, Tuya Pal, Boris Pasche, Robert Pilarski, Gwen Reiser, Kristen Mahoney Shannon, Jeffrey R. Smith, Elizabeth Swisher and Jeffrey N. Weitzel

individuals. Table 1 provides a glossary of genetic terms. Hereditary Breast or Breast/Ovarian Cancer Syndromes Breast cancer is the most prevalent type of cancer and the second leading cause of cancer death in women in the United States. Up to 10

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Stanford Hospital and Clinics

Recent advances in molecular genetics have identified several genes associated with inherited susceptibility to cancer and have provided a means to begin identifying individuals and families with an increased risk of cancer. This rapid expansion of knowledge about cancer genetics has implications for all aspects of cancer management, including prevention, screening, and treatment. These guidelines specifically address hereditary breast/ovarian cancer syndrome (HBOC), Li-Fraumeni syndrome, and Cowden syndrome. These guidelines were developed understanding that much of our knowledge of how the rapidly emerging field of molecular genetics can be applied clinically is preliminary and that flexibility is needed when applying these guidelines to individual families.

For the most recent version of the guidelines, please visit

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Susan M. Domchek, Jill E. Stopfer and Timothy R. Rebbeck

-abdominal carcinomatosis after prophylactic oophorectomy in women of hereditary breast ovarian cancer syndrome kindreds associated with BRCA1 and BRCA2 mutations . Gynecol Oncol 2005 ; 97 : 457 – 467 . 16. Salazar H Godwin AK Daly MB . Microscopic benign and

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Deborah Cragun, Anne Weidner, Ann Tezak, Brenda Zuniga, Georgia L. Wiesner and Tuya Pal

. 15943558 10.1089/gte.2005.9.167 3. Roukos DH , Briasoulis E . Individualized preventive and therapeutic management of hereditary breast ovarian cancer syndrome . Nat Clin Pract Oncol 2007 ; 4 : 578 – 590 . 10.1038/ncponc0930 17898808 4. Narod SA