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Borislav Hristov, Ori Shokek and Deborah A. Frassica

Linstadt DE Bahary JP . Experience in charged particle of tumors of the skull base: 1977–1992 . Int J Radiat Oncol Biol Phys 1994 ; 29 : 647 – 655 . 33. Huvos AG . Chordoma . In : Bone Tumors: Diagnosis, Treatment and Prognosis

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Jorge Casas-Ganem and John H. Healey

2004 ; 42 : 477 – 480 . 5 Huvos AG . Bone Tumors . Diagnosis, Treatment, and Prognosis , 2nd ed. Philadelphia, PA : W.B. Saunders Company ; 1991 . 6 Overholtzer M Rao PH Favis R . The presence of p53 mutations in human

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Michael J. Monument and Kevin B. Jones

field of bone tumors; although they probably will in the future, this review focuses on genes instead. Even the application of genetic knowledge to bone tumors strays deeply into the research realm and away from clinical standards and practices. For each

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Judd E. Cummings, J. Andrew Ellzey and Robert K. Heck

tumors: a primer . Semin Roentgenol 2004 ; 39 : 361 – 372 . 16. Unni KK . Dahlin's Bone Tumors. General Aspects and Data on 11,087 Cases, 5th ed. Philadelphia : Lippincott-Raven , 1996 : 7 – 8 . 17. Peabody TD Gibbs CP Simon

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J. Sybil Biermann

polymethyl-methacrylate, an overall recurrence rate of 22% has been reported. 2 When these bone tumors do recur, however, they are highly problematic, admitted Dr. Biermann. “It often involves replacing and restoring the joint in an otherwise young person

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Rodger J. Winn

NCCN believes that the best management of any cancer patient is in a clinical trial This year, 9,420 Americans will develop soft-tissue sarcomas and another 2,570 will develop bone tumors, accounting for less than 1% of all tumors.1 Despite the relative rarity of these tumors, however, the collected articles in this issue show a broad range of vibrant investigational programs seeking to unravel complex biologic mechanisms that may lead to more effective treatments. In line with research focus across oncology, the studies include basic research into genetic and molecular pathways, translational studies that bring laboratory findings into the clinical arena, and a wide array of clinical trials spanning the gamut, from phase I studies with new targeted agents to broad phase III studies asking basic questions about adjuvant treatments. As in all human endeavors, concerted efforts are immeasurably spurred by a “win.” Certainly, showing that imatinib mesylate produces significant responses in advanced gastrointestinal stromal tumors (GIST)2 illustrates the enormous impetus that can be provided by a ground-breaking discovery. For instance, the imatinib findings came out in 2002. In 2000 PubMed listed 43 articles related to GIST, and in 2004, PubMed lists 216 articles, with more to come as year-end journals are entered into their database. This newly sparked interest involves a broad range of laboratory and clinical investigators, leading to a synergy that impacts the entire spectrum of disease management.3 Undoubtedly, the impact of a new approach generates ever-widening ripples. The beneficial results with...
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Osteosarcoma and Ewing's Sarcoma Schuetze Scott M. MD, PhD 04 2007 5 5 4 4 449 449 455 455 0050449 10.6004/jnccn.2007.0039 The Role of Radiation Treatment in the Contemporary Management of Bone Tumors Hristov Borislav MD Shokek Ori MD

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Side Riverwoman Barbara 3 2005 3 3 2 2 122 122 123 123 10.6004/jnccn.2005.0009 Elucidation of the Molecular Mechanisms of Malignant Bone Tumors: Refining Diagnosis and Identifying Novel Targets for Treatment Casas-Ganem Jorge * MD

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Brian P. Rubin and John R. Goldblum

specimens from patients with soft tissue tumors of intermediate malignant potential, malignant soft tissue tumors, and benign/locally aggressive and malignant bone tumors . Arch Pathol Lab Med 2006 ; 130 : 1616 – 1629 . 25. Coindre JM

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R. Lor Randall and William Gowski

– 304 . 15 Pritchard DJ Lunke RJ Taylor WF . Chondrosarcoma: a clinicopathologic and statistical analysis . Cancer 1980 ; 45 : 149 – 157 . 16 Unni KK . Dahlin's Bone Tumors: General Aspects and Data on 11,087 Cases , 5th ed