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Rashmi Chugh

and refractory setting of both diseases. Chondrosarcoma remains a disease without any effective systemic therapy. This article provides an overview of currently available experimental treatments and clinical trials in bone sarcomas, and the

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Judd E. Cummings, J. Andrew Ellzey and Robert K. Heck

the course of chemotherapy: a study in patients with bone sarcoma . Skeletal Radiol 1994 ; 23 : 181 – 185 . 50. Li KC Hopkins KL Moore SG . Magnetization transfer contrast MRI of musculoskeletal neoplasms . Skeletal Radiol 1995 ; 24

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Carol D. Morris

Despite decades of success in the management of bone sarcomas, the pelvis remains an elusive anatomic site for all members of the bone sarcoma disease management team. Surgeons continue to struggle to obtain negative margins and reconstruct a

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Suzanne George

discussed updates in the treatment of STS. “This space has been much more active with regard to drug development and new drug indications than the bone sarcomas space,” she noted. “But hopefully that will change soon.” Overview of Sarcomas Sarcomas are a

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Scott M. Schuetze

for patients aged under 40 years with bone sarcoma in Britain, 1980–1994 . Br J Cancer 2006 ; 94 : 22 – 29 . 4. Bacci G Mercuri M Longhi A . Neoadjuvant chemotherapy for the treatment of osteosarcoma of the extremities: a comparison of

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Andrew Wagner

versus CYVADIC versus doxorubicin plus ifosfamide in first-line treatment of advanced soft tissue sarcomas: a randomized study of the European Organization for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group . J Clin Oncol 1995 , 13

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Somaiah Neeta MD Yasko Alan W. MD 6 2010 8 8 6 6 688 688 712 712 0080688 10.6004/jnccn.2010.0051 Experimental Therapies and Clinical Trials in Bone Sarcoma Chugh Rashmi MD 6 2010 8 8 6 6 715 715 725 725 0080715 10.6004/jnccn

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420 420 420 420 0050420 10.6004/jnccn.2007.0037 Imaging of Bone Sarcomas Cummings Judd E. MD Ellzey J. Andrew MD Heck Robert K. MD 04 2007 5 5 4 4 438 438 447 447 0050438 10.6004/jnccn.2007.0038 Chemotherapy in the Management of

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J. Sybil Biermann

optimally it should be performed at a center that will do definitive management. “The problem with bone sarcomas is they are mesenchymally derived tissues,” explained Dr. Biermann. “So unlike carcinomas, they seed the tissues on the way out, and everywhere

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Katherine Cotangco, Mary Meram and M. Patrick Lowe

, Tawbi et al 1 reported on a multicenter, 2-cohort, single-arm, open-label phase II trial examining the use of pembrolizumab in soft tissue and bone sarcoma in patients previously treated using up to 3 lines of chemotherapy (N=86). A subgroup analysis of