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Antonio V. Gonzalez, Andrew J. Ullmann, Nikolaos G. Almyroudis and Brahm H. Segal

Burch PA . Invasive pulmonary aspergillosis in acute leukemia. The contribution of CT to early diagnosis and aggressive management . Chest 1987 ; 92 : 95 – 99 . 5. Caillot D Casasnovas O Bernard A . Improved management of invasive

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Johan Maertens, Kristel Buvé and Elias Anaissie

-emptive antifungal therapy: still a way to go . Curr Opin Infect Dis 2006 ; 19 : 551 – 556 . 10. Mennink-Kersten MA Donnelly JP Verweij PE . Detection of circulating galactomannan for the diagnosis and management of invasive aspergillosis . Lancet

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Mellar P. Davis

Aspergillus; invasive aspergillosis has been described in marijuana smokers undergoing renal transplant, treated for leukemia or solid tumors, with AIDs, and undergoing chronic steroid therapy. 67 For this reason, the use of smoked cannabis in individuals

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Maxim Norkin and John R. Wingard

persistent or recurrent neutropenic fevers; it is not responsive to empiric antibiotics and is typically seen late during the first or second week of neutropenia or later. In contrast, invasive aspergillosis (IA) typically develops beyond 2 weeks of

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Thomas A. Cumbo and Brahm H. Segal

Hurwitz S . Prolonged granulocytopenia: the major risk factor for invasive pulmonary aspergillosis in patients with acute leukemia . Ann Intern Med 1984 ; 100 : 345 – 351 . 27 Marr KA Carter RA Crippa F . Epidemiology and outcome of mould

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Lindsey Robert Baden, Sankar Swaminathan, Michael Angarone, Gayle Blouin, Bernard C. Camins, Corey Casper, Brenda Cooper, Erik R. Dubberke, Ashley Morris Engemann, Alison G. Freifeld, John N. Greene, James I. Ito, Daniel R. Kaul, Mark E. Lustberg, Jose G. Montoya, Ken Rolston, Gowri Satyanarayana, Brahm Segal, Susan K. Seo, Shmuel Shoham, Randy Taplitz, Jeffrey Topal, John W. Wilson, Karin G. Hoffmann and Courtney Smith

incidence of invasive aspergillosis (1% vs 7%; P <.001), and was associated with a significant survival benefit ( P =.04) versus the fluconazole/itraconazole arm. 26 Data from a prospective randomized study showed that posaconazole was as effective as

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Lindsey Robert Baden, William Bensinger, Michael Angarone, Corey Casper, Erik R. Dubberke, Alison G. Freifeld, Ramiro Garzon, John N. Greene, John P. Greer, James I. Ito, Judith E. Karp, Daniel R. Kaul, Earl King, Emily Mackler, Kieren A. Marr, Jose G. Montoya, Ashley Morris-Engemann, Peter G. Pappas, Ken Rolston, Brahm Segal, Susan K. Seo, Sankar Swaminathan, Maoko Naganuma and Dorothy A. Shead

delivery to lungs while avoiding systemic toxicity. A recent randomized, placebo-controlled trial found that aerosolized liposomal amphotericin B was useful for preventing invasive pulmonary aspergillosis in patients with prolonged neutropenia. 110

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Peter L. Greenberg, Cynthia K. Rigsby, Richard M. Stone, H. Joachim Deeg, Steven D. Gore, Michael M. Millenson, Stephen D. Nimer, Margaret R. O'Donnell, Paul J. Shami and Rashmi Kumar

Remacha AF Sarda P . Frequent severe liver iron overload after stem cell transplantation and its possible association with invasive aspergillosis . Bone Marrow Transplant 2004 ; 34 : 505 – 509 . 62 Strasser SI Kowdley KV Sale GE McDonald GB

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Samuel L. Aitken, Jerod L. Nagel, Lilian Abbo, William Alegria, Jason N. Barreto, Sanjeet Dadwal, Alison G. Freifeld, Rupali Jain, Steven A. Pergam, Frank P. Tverdek, Susan K. Seo and on behalf of the Antimicrobial Stewardship in Cancer Consortium ASCC

example, improved survival in adult and pediatric patients with neutropenia has been shown after implementation of local fever and neutropenia practice protocols, and higher response rates have been shown for invasive aspergillosis when first

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H. Joachim Deeg and Marcos de Lima

Parody R Fukuda T . Impact of the intensity of the pretransplantation conditioning regimen in patients with prior invasive aspergillosis undergoing allogeneic hematopoietic stem cell transplantation: a retrospective survey of the Infectious Diseases