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Radiation-Induced Nausea and Vomiting

Susan Urba

Radiation-induced nausea and vomiting is a common problem for cancer patients. The emetogenic potential of radiation depends greatly on the location of the radiation field, the size of the radiation field, and the fractionation scheme. Radiation fields can be categorized as having high, moderate, low, or minimal emetogenic risk, and treatment differs accordingly. The National Comprehensive Cancer Network, the Multinational Association of Supportive Care in Cancer, and the American Society of Clinical Oncology publish clinical practice guidelines addressing the issue of radiation-induced nausea and vomiting. This article reviews the treatment recommendations for each category of radiation-induced nausea and vomiting from these national and international guideline committees and provides the rationale for these recommendations.

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Antiemetic Studies on the NK1 Receptor Antagonist Aprepitant

John P. Stoutenburg and Harry Raftopoulos

comparing 5-HT3 receptor antagonists to conventional anti-emetics in the prophylaxis of acute chemotherapy-induced vomiting . Eur J Cancer 1997 ; 33 : 66 – 74 . 2 Grunberg SM Hansen M Deuson R : Incidence and impact of nausea/vomiting with

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QIM20-130: An Immediate Care Center for Oncology Patients “Symptom Management Doesn’t Require the Emergency Department”

Penny Moore

providers evaluate and establish a treatment plan which may include diagnostic evaluation, intravenous fluids, antibiotics, anti-emetics, pain management, and transfusion of blood products and wound management. Results: Patient volume in the ICC has

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Antiemesis

David S. Ettinger, Debra K. Armstrong, Sally Barbour, Michael J. Berger, Philip J. Bierman, Bob Bradbury, Georgianna Ellis, Steve Kirkegaard, Dwight D. Kloth, Mark G. Kris, Dean Lim, Michael Anne Markiewicz, Lida Nabati, Carli Nesheiwat, Hope S. Rugo, Steven M. Sorscher, Lisa Stucky-Marshal, Barbara Todaro, and Susan Urba

Roila F Boschetti E Tonato M . Predictive factors of delayed emesis in cisplatin patients and anti-emetic activity and tolerability of metoclopramide or dexamethasone . Am J Clin Oncol 1991 ; 14 : 238 – 242 . 18 Moher D Arthur AZ Peter JL

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Are All 5-HT3 Receptor Antagonists the Same?

Robert McNulty

PJ Rogosheske J Burns L . A prospective randomized trial of the anti-emetic efficacy of ondansetron and granisetron during bone marrow transplantation . Biol Blood Marrow Transplant 1999 ; 5 : 386 – 393 . 18. Slaby J Trneny M Prochazka

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Prevention of Emesis from Multiple-Day and High-Dose Chemotherapy Regimens

Rudolph M. Navari

: 494s . Abstract 8607 . 54. Diemunsch P Grelot L . Potential of substance P antagonists as antiemetics . Drugs 2000 ; 60 : 533 – 546 . 55. Watson JW Gonsalves SF Rossa AA . The anti-emetic effects of CP-99,994 in the ferret

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NCCN Guidelines Insights: Antiemesis, Version 2.2017

Michael J. Berger, David S. Ettinger, Jonathan Aston, Sally Barbour, Jason Bergsbaken, Philip J. Bierman, Debra Brandt, Dawn E. Dolan, Georgiana Ellis, Eun Jeong Kim, Steve Kirkegaard, Dwight D. Kloth, Ruth Lagman, Dean Lim, Charles Loprinzi, Cynthia X. Ma, Victoria Maurer, Laura Boehnke Michaud, Lisle M. Nabell, Kim Noonan, Eric Roeland, Hope S. Rugo, Lee S. Schwartzberg, Bridget Scullion, John Timoney, Barbara Todaro, Susan G. Urba, Dorothy A. Shead, and Miranda Hughes

efficacy of granisetron as a prophylactic anti-emetic and intervention agent in high-dose cisplatin-induced emesis . Eur J Cancer 1990 ; 26 ( Suppl 1 ): S23 – 27 . 35. De Mulder PH Seynaeve C Vermorken JB . Ondansetron compared with high

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Antiemesis

David S. Ettinger, Debra K. Armstrong, Sally Barbour, Michael J. Berger, Philip J. Bierman, Bob Bradbury, Georgianna Ellis, Steve Kirkegaard, Dwight D. Kloth, Mark G. Kris, Dean Lim, Laura Boehnke Michaud, Lida Nabati, Kim Noonan, Hope S. Rugo, Darby Siler, Steven M. Sorscher, Sundae Stelts, Lisa Stucky-Marshall, Barbara Todaro, and Susan G. Urba

. Ann Intern Med 1981 ; 95 : 352 – 359 . 14 Dodds LJ . The control of cancer chemotherapy-induced nausea and vomiting . J Clin Hosp Pharm 1985 ; 10 : 143 – 166 . 15 Aapro MS . Palonosetron as an anti-emetic and anti

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Cannabinoids in the Treatment of Chemotherapy-Induced Nausea and Vomiting

Barbara Todaro

Cannabis sativa on chemotherapy-induced nausea and vomiting among cancer patients: systemic review and meta-analysis . Eur J Cancer Care (Engl) 2008 ; 17 : 431 – 443 . 9 Ahmedzai S Carlyle DL Calder IT Moran F . Anti-emetic efficacy and

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Corticosteroids in the Treatment of Chemotherapy-Induced Nausea and Vomiting

Sally Yowell Barbour

anti-emetic glucocorticoids in cancer . Cancer Biol Ther 2006 ; 5 : 921 – 922 .