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Celestia S. Higano

Androgen deprivation therapy (ADT) has been the standard of care for metastatic prostate cancer since 1941, when Huggins and Hodges 1 demonstrated the effect of androgens on prostate cancer and the impact of orchiectomy on bone pain symptoms. Hot

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Miren Gaztañaga and Juanita Crook

range of indications exposes ever-increasing numbers of men to the side effects of ADT. 5 Adverse Effects of Androgen Deprivation The side effects of ADT are well documented in the literature. Initially, the most obvious symptoms of sexual

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Jason Hu, Armen G. Aprikian, Marie Vanhuyse and Alice Dragomir

important aspect to consider. Androgen deprivation therapy (ADT) is a cornerstone of advanced PCa treatment, and it is estimated that nearly 1 in 2 patients with PCa will receive some form of ADT during their disease course. 3 , 4 The role of ADT is strongly

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Brandon A. Mahal, Ming-Hui Chen, Andrew A. Renshaw, Marian J. Loffredo, Philip W. Kantoff and Anthony V. D'Amico

the study cohort, stratified by PSA-DT and PSA level at the time of salvage ADT. PSA-DT Figure 1. CONSORT diagram. Abbreviations: 3D-CRT, 3D conformal radiation therapy; ADT, androgen deprivation therapy; LHRH, luteinizing hormone

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U-Syn Ha, Jin Bong Choi, Jung Im Shim, Minjoo Kang, Eunjung Park, Shinhee Kang, Jooyeon Park, Jangmi Yang, Insun Choi, Jeonghoon Ahn, Cheol Kwak, Chang Wook Jeong, Choung Soo Kim, Seok-Soo Byun, Seong Il Seo, Hyun Moo Lee, Seung-Ju Lee, Seung Hwan Lee, Byung Ha Chung and Ji Youl Lee

Background Although major groups or guidelines do not recommend primary androgen deprivation therapy (PADT) as primary treatment of nonmetastatic prostate cancer, 1 , 2 a considerable number of physicians have used PADT for nonmetastatic prostate

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Philip J. Saylor and Matthew R. Smith

/print certificate. Learning Objectives Upon completion of this activity, participants will be able to: • Identify clinical scenarios in which androgen deprivation therapy (ADT) is most useful in the treatment of prostate cancer • Describe

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James L. Mohler

The strategic application of androgen deprivation therapy (ADT) in the clinic is still evolving, according to James L. Mohler, MD, Chair of the Department of Urology and Associate Director of Translational Research, Roswell Park Cancer Institute

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Dennis R. Taaffe, Robert U. Newton, Nigel Spry, David J. Joseph and Daniel A. Galvão

Background Androgen deprivation therapy (ADT) is used extensively in the management of localized and advanced prostate cancer (PCa). 1 Although effective in delaying disease progression and enhancing survival, 1 , 2 ADT is associated with an array

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Masaki Shiota

Since the work of Huggins and Hodges in the mid 1900s, primary androgen deprivation therapy (PADT) has been the backbone therapy for metastatic prostate cancer. It has recently been combined with upfront docetaxel or abiraterone. Although PADT

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James L. Mohler

Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Prostate Cancer (CaP) and the preparation of my talk for the NCCN 21st Annual Conference caused me to stop and think about androgen deprivation therapy (ADT). ADT is something that I have spent