P atients with breast cancer who are at relatively low risk for recurrence or mortality after local therapy (surgery with or without radiation) face a “grey zone” decision about whether to undergo adjuvant therapy. 1 The choice of therapy
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Jeffrey K. Belkora, David W. Hutton, Dan H. Moore, and Laura A. Siminoff
Robert W. Carlson, Elizabeth Brown, Harold J. Burstein, William J. Gradishar, Clifford A. Hudis, Charles Loprinzi, Eleftherios Paul Mamounas, Edith A. Perez, Kathleen Pritchard, Peter Ravdin, Abram Recht, George Somlo, Richard L. Theriault, Eric P. Winer, Antonio C. Wolff, and for the NCCN Adjuvant Therapy for Breast Cancer Task Force
NCCN Adjuvant Therapy for Breast Cancer Task Force Members *Robert W. Carlson, MD / Chair#† ¶¶ Stanford Hospital and Clinics Donald A. Berry, PhD†† The University of Texas M. D. Anderson Cancer Center *Elizabeth Brown, MD National Comprehensive
Jennifer A. Ligibel
prognosis in women with early-stage breast cancer. Exercise Intervention Studies in Breast Cancer Survivors Dozens of small-to-moderate–sized interventional studies have tested the feasibility and potential benefits of exercise in the adjuvant
Daphna Y. Spiegel, Matthew J. Boyer, Julian C. Hong, Christina D. Williams, Michael J. Kelley, Joseph K. Salama, and Manisha Palta
resection and consideration of adjuvant chemotherapy (AC) based on patient and tumor characteristics. The role of AC in colon cancer is supported by the results of NSABP C01, 1 a pooled analysis, 2 and the MOSAIC trial 3 showing improvement in disease
Matthew E. Nielsen, Bruce J. Trock, and Patrick C. Walsh
Guidelines in Oncology: Prostate Cancer states “new evidence supports offering adjuvant/salvage RT in all men with adverse pathologic features or detectable PSA” 3 (to view the most recent version of these guidelines, visit the NCCN Web site at www
Katherine Van Loon and Alan P. Venook
Adjuvant therapy for colon cancer evolved in an additive fashion. In the 1980s, 5-fluorouracil (5-FU) administered as a daily bolus regimen made the first positive impact of any therapy on colon cancer survival. 1 The ensuing decade of research
Maxwell T. Vergo and Al B. Benson III
compared with those with stage II (T4b–a,N0), with 5-year survivals of 83% to 91% versus 58% to 79%, respectively, 5 and yet are offered adjuvant chemotherapy. Evidence shows that stage II and III disease have very similar gene expression profiles and
Anthony J. Olszanski
Patients with stage III melanoma are at high risk for disease recurrence, but adjuvant therapy—including targeted therapy and immunotherapy—may prevent or delay relapse, according to Anthony J. Olszanski, MD, RPh, Associate Professor and Vice Chair
Jashodeep Datta, Matthew T. McMillan, Eric K. Shang, Ronac Mamtani, Russell S. Lewis Jr, Rachel R. Kelz, Ursina Teitelbaum, John P. Plastaras, Jeffrey A. Drebin, Douglas L. Fraker, Giorgos C. Karakousis, and Robert E. Roses
receiving adjuvant CRT demonstrated significantly improved median disease-free survival (DFS; 30 vs 19 months; P <.001) and overall survival (OS; 36 vs 27 months; P =.005) compared with those undergoing surgery alone. 4 This survival benefit persisted on
Andrew H. Ko and Christopher H. Crane
, despite evaluation of various chemotherapy and radiation regimens in the adjuvant setting. Several studies have shown that superior outcomes may be achieved when pancreatic cancer surgeries are performed at high-volume hospitals by experienced surgeons 8
