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Michael Angarone and Michael G. Ison

A leading complication of leukemia therapy and stem cell transplantation is opportunistic viral infections. Infections caused by cytomegalovirus, herpes simplex, varicella-zoster, Epstein-Barr, and the community respiratory viruses are associated with significant morbidity and mortality in this highly immunosuppressed population. Fortunately, a growing armamentarium is allowing more effective prophylaxis of these pathogens. This article reviews the epidemiology and prophylactic strategies available for these common opportunistic viral pathogens.

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Sophia Koo and Lindsey R. Baden

stem cell transplantation with alemtuzumab . Bone Marrow Transplant 2005 ; 36 : 797 – 802 . 55. Chakrabarti S Mautner V Osman H . Adenovirus infections following allogeneic stem cell transplantation: incidence and outcome in relation to

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Sajeel Chowdhary and Marc Chamberlain

″-triethylenethiophosphoramide [thioTEPA (NSC 6396)] in the treatment of malignant meningeal disease: phase I-II study . Cancer 1976 ; 38 : 1471 – 1475 . 61 Driesse MJ Esandi MC Kros JM . Intra-CSF administered recombinant adenovirus causes an immune response

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Patrick C. Ma and Ravi Salgia

FHIT gene 3p14.2 is abnormal in lung cancer . Cell 1996 ; 85 : 17 – 26 . 12 Ji L Fang B Yen N . Induction of apoptosis and inhibition of tumorigenicity and tumor growth by adenovirus vector-mediated fragile histidine triad (FHIT) gene

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Annette M. Lim, Graham R. Taylor, Andrew Fellowes, Laird Cameron, Belinda Lee, Rodney J. Hicks, Grant A. McArthur, Christopher Angel, Benjamin Solomon and Danny Rischin

Clin Invest 1993 ; 91 : 179 – 184 . 40. Blagosklonny MV Giannakakou P Wojtowicz M . Effects of p53-expressing adenovirus on the chemosensitivity and differentiation of anaplastic thyroid cancer cells . J Clin Endocrinol Metab 1998 ; 83

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David Y. Oh, Alan P. Venook and Lawrence Fong

cohort, although the colon cancer subgroup demonstrated some improvement in both indices. 21 There is an ongoing pilot study using GVAX (adenovirus-mediated granulocyte-macrophage colony-stimulating factor [GM-CSF] expression) in irradiated autologous

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Ndiya Ogba, Nicole M. Arwood, Nancy L. Bartlett, Mara Bloom, Patrick Brown, Christine Brown, Elizabeth Lihua Budde, Robert Carlson, Stephanie Farnia, Terry J. Fry, Morgan Garber, Rebecca A. Gardner, Lauren Gurschick, Patricia Kropf, Jeff J. Reitan, Craig Sauter, Bijal Shah, Elizabeth J. Shpall and Steven T. Rosen

contribute to procedure-related mortality and morbidity. 121 Some studies have shown that matched donor-derived virus-specific T cells specific for Epstein-Barr virus (EBV), cytomegalovirus (CMV), or adenovirus are effective at managing viral infections in

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Lindsey Robert Baden, Sankar Swaminathan, Michael Angarone, Gayle Blouin, Bernard C. Camins, Corey Casper, Brenda Cooper, Erik R. Dubberke, Ashley Morris Engemann, Alison G. Freifeld, John N. Greene, James I. Ito, Daniel R. Kaul, Mark E. Lustberg, Jose G. Montoya, Ken Rolston, Gowri Satyanarayana, Brahm Segal, Susan K. Seo, Shmuel Shoham, Randy Taplitz, Jeffrey Topal, John W. Wilson, Karin G. Hoffmann and Courtney Smith

. Screening for Respiratory Viruses: Rapid PCR panels should be considered for detection of respiratory viruses including respiratory syncytial virus (RSV), influenza, parainfluenza virus, adenovirus, rhinovirus, and metapneumovirus in patients with cough and