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Boyu Hu, Jay L. Patel, Randa Tao, Richard B. Cannon, Marcus Monroe, and Gaurav Goyal

mutations. 2 This report presents the first case of KRAS- mutated HS successfully treated to near complete remission with the MEK inhibitor trametinib. Case Report A 69-year-old White man presented to his primary care office for a routine visit, at

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Rohan Maniar, Stephanie M. Gallitano, Sameera Husain, Golnaz Moazami, Michael J. Weiss, and Catherine A. Shu

painful eruption over the bilateral lower extremities. First-line treatment with a BRAF inhibitor, dabrafenib at 150 mg twice daily, and an MEK inhibitor, trametinib at 2 mg daily, had been initiated 3 months prior. She had no pertinent dermatologic

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Tanner M. Johanns, Cole J. Ferguson, Patrick M. Grierson, Sonika Dahiya, and George Ansstas

(LGGs; Table 1 ). This report describes the use of combination dabrafenib (BRAF inhibitor) and trametinib (MEK inhibitor) in 2 adults with high-grade gliomas (HGGs). The first patient was treated at time of diagnosis, whereas the second was treated at

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Victor T.G. Lin, Lisle M. Nabell, Sharon A. Spencer, William R. Carroll, Shuko Harada, and Eddy S. Yang

was identified. After discussion by the UAB MTB, 1 he was started on targeted therapy with the BRAF inhibitor dabrafenib and the MEK inhibitor trametinib, in addition to zoledronic acid for his bony metastases ( Figure 1 ). Dabrafenib and trametinib

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Rishi Agarwal, Jiang Wang, Keith Wilson, William Barrett, and John C. Morris

dabrafenib and trametinib, and experienced a response. Case Report A 47-year-old woman with a history of moderately severe rheumatoid arthritis treated with infliximab and methotrexate presented with a 1-month history of a rapidly enlarging left neck

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Anastasia Drobysheva, Laura J. Klesse, Daniel C. Bowers, Veena Rajaram, Dinesh Rakheja, Charles F. Timmons, Jason Wang, Korgun Koral, Lynn Gargan, Erica Ramos, and Jason Y. Park

treatment of low- and high-grade gliomas with BRAF inhibitors (vemurafenib and dabrafenib). 8 – 13 There is only a single report of 2 patients with PAs who were treated with trametinib, a MAPK pathway inhibitor, 5 and no reports on MAPK pathway

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Presenter: Genevieve Boland

adjuvant therapy trials of immune checkpoint inhibitors (ICIs) in stage III–IV melanoma and their outcomes. Figure 1. Adjuvant therapy in stage III–IV melanoma. Abbreviations: D/T, dabrafenib + trametinib; DMFS, distant metastasis–free survival; HR

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Daniel G. Coit, John A. Thompson, Robert Andtbacka, Christopher J. Anker, Christopher K. Bichakjian, William E. Carson III, Gregory A. Daniels, Adil Daud, Dominick DiMaio, Martin D. Fleming, Rene Gonzalez, Valerie Guild, Allan C. Halpern, F. Stephen Hodi Jr, Mark C. Kelley, Nikhil I. Khushalani, Ragini R. Kudchadkar, Julie R. Lange, Mary C. Martini, Anthony J. Olszanski, Merrick I. Ross, April Salama, Susan M. Swetter, Kenneth K. Tanabe, Vijay Trisal, Marshall M. Urist, Nicole R. McMillian, and Maria Ho

%, respectively). 3 Treatment options for patients harboring BRAF V600 mutations are increasing with the approval of additional targeted inhibitors, dabrafenib and trametinib. However, because of the rapid development of therapeutic resistance after initial

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Anthony J. Olszanski

stage IIC disease, who are at higher risk of recurrence than those with stage IIIA disease, can also be considered for testing. In the randomized COMBI-AD trial, combining the BRAF inhibitor dabrafenib with the MEK inhibitor trametinib demonstrated

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Karen L. Reckamp

when alectinib is used as frontline therapy,” she noted. The 2018 NCCN Guidelines include recommendations for progression on crizotinib, alectinib, Figure 3. Dabrafenib plus trametinib in BRAF V600E–mutant lung cancer. Reprinted from