Search Results

You are looking at 1 - 10 of 135 items for :

Clear All
Full access

Neil P. Shah

Discontinuation of tyrosine kinase inhibitor (TKI) therapy appears to be safe among adult patients with chronic myeloid leukemia (CML) in the chronic phase who have achieved and maintained a deep molecular response (DMR), according to the updated

Full access

Susan O'Brien, Ellin Berman, Joseph O. Moore, Javier Pinilla-Ibarz, Jerald P. Radich, Paul J. Shami, B. Douglas Smith, David S. Snyder, Hema M. Sundar, Moshe Talpaz and Meir Wetzler

, nilotinib, 300 mg daily, had the lowest rates of discontinuation from adverse events or laboratory abnormalities. Are Early Short-Term End Points Good Enough to Recommend Second-Generation TKIs at Diagnosis? Although most patients experience response to

Full access

Irbaz Bin Riaz, Saad Ullah Malik, Muhammad Husnain, Qurat Ul Ain Riaz Sipra, Warda Faridi, Farva R. Gondal, Thanh Ho, Siddhartha Yadav, Zhen Wang and Manish Kohli

Background: Four large RCTs (ASSURE, S-TARC, PROTECT, ATLAS) tested adjuvant VEGF-TKI therapy in high risk RCC. The results were variable for efficacy and there were concerns for increased toxicity and decline in quality of life (QoL). We performed

Full access

Jerald P. Radich, Michael Deininger, Camille N. Abboud, Jessica K. Altman, Ellin Berman, Ravi Bhatia, Bhavana Bhatnagar, Peter Curtin, Daniel J. DeAngelo, Jason Gotlib, Gabriela Hobbs, Madan Jagasia, Hagop M. Kantarjian, Lori Maness, Leland Metheny, Joseph O. Moore, Arnel Pallera, Philip Pancari, Mrinal Patnaik, Enkhtsetseg Purev, Michal G. Rose, Neil P. Shah, B. Douglas Smith, David S. Snyder, Kendra L. Sweet, Moshe Talpaz, James Thompson, David T. Yang, Kristina M. Gregory and Hema Sundar

with tyrosine kinase inhibitors (TKIs) in prospective studies, the presence of ACA/Ph + at the time of diagnosis was not associated with worse prognosis. 16 Patients with ACA/Ph + at diagnosis should be watched carefully for evidence of therapy

Full access

Jerald P. Radich

use of tyrosine kinase inhibitors (TKIs), survival in blast crisis has not clearly improved with these targeted agents. Progression to blast crisis in CML is a phenomenon that is still not completely understood. Although definitions of both

Full access

Gary R. Hudes, Michael A. Carducci, Toni K. Choueiri, Peg Esper, Eric Jonasch, Rashmi Kumar, Kim A. Margolin, M. Dror Michaelson, Robert J. Motzer, Roberto Pili, Susan Roethke and Sandy Srinivas

, stimulating multiple downstream signaling pathways and leading to cell growth, proliferation, and angiogenesis. The tyrosine kinase inhibitors (TKIs) block the downstream signaling of the receptor tyrosine kinases. Figure 1 Therapeutic targets in renal cell

Full access

Alejandro Garcia-Horton and Jeffrey H. Lipton

The prognosis of chronic myeloid leukemia (CML) has greatly improved since the clinical use of tyrosine kinase inhibitors (TKIs) started with imatinib in the early 2000s. 1 It is now considered a chronic disease, with its incidence being stable

Full access

Jorge Cortes, John M. Goldman and Timothy Hughes

The treatment landscape for chronic myelogenous leukemia (CML) dramatically changed after the FDA approved the tyrosine kinase inhibitor (TKI) imatinib mesylate (Gleevec, Novartis) in 2001. Imatinib targets BCR-ABL, a fusion protein expressed by

Full access

Jerald P. Radich

Conference, Dr. Radich took stock of CML in 2013, noting improvements that include multiple tyrosine kinase inhibitors (TKIs) and sensitive measures of disease burden and thus response to therapy. Transplant also remains an effective salvage regimen that is

Full access

Michael W. Deininger, Neil P. Shah, Jessica K. Altman, Ellin Berman, Ravi Bhatia, Bhavana Bhatnagar, Daniel J. DeAngelo, Jason Gotlib, Gabriela Hobbs, Lori Maness, Monica Mead, Leland Metheny, Sanjay Mohan, Joseph O. Moore, Kiran Naqvi, Vivian Oehler, Arnel M. Pallera, Mrinal Patnaik, Keith Pratz, Iskra Pusic, Michal G. Rose, B. Douglas Smith, David S. Snyder, Kendra L. Sweet, Moshe Talpaz, James Thompson, David T. Yang, Kristina M. Gregory and Hema Sundar

, e14a3, e6a2) have also been detected in about 1%–2% of patients with CML. The proportion of different BCR-ABL1 transcripts and the impact of BCR-ABL1 transcript type on response to tyrosine kinase inhibitor (TKI) therapy are discussed in “BCR