Background: Germline genetic testing is recommended for men with metastatic or high-risk prostate cancer to inform treatment and risk management for other cancers and inform genetic testing in at-risk relatives. However, relatively few patients with prostate cancer undergo genetic testing. Given the low rate of testing and increasing demands on genetic service providers, strategies are needed that reduce barriers to testing while conserving genetic counseling resources. The primary goal of this study was to determine whether a proactive and streamlined “traceback” approach could yield increased genetic testing participation among prostate cancer survivors. Methods: We randomized 107 survivors of metastatic and high-risk prostate cancer to streamlined testing (ST) versus enhanced usual care (EUC). ST participants were proactively provided with print genetic education materials and the option to proceed to genetic testing without pre-test genetic counseling. EUC participants were sent a letter from their physician advising them of their eligibility for genetic testing and recommending they schedule genetic counseling. The primary outcome was genetic testing participation. Secondary outcomes were distress, knowledge, decision satisfaction, and regret. Results: In the ST group, 41.5% of participants completed genetic testing compared with 27.8% in the EUC group. After adjusting for education and marital status, the odds of testing were more than twice as high for the ST group as for the EUC group (odds ratio, 2.57; 95% CI, 1.05–6.29). The groups did not differ on any of the psychosocial outcomes at the 3-month follow-up. Conclusions: Proactive outreach paired with streamlined genetic testing delivery may be a safe, effective, and resource-efficient approach to facilitate traceback genetic testing in prostate cancer survivors.
Search Results
Pilot Trial of Streamlined Genetic Education and Traceback Genetic Testing in Prostate Cancer Survivors
Marc D. Schwartz, Beth N. Peshkin, Claudine Isaacs, Christopher Grisham, Nora J. Holmes, Lia J. Sorgen, Sean Collins, Nancy Dawson, Colleen McGuire, Tobechukwu Okobi, Kelsey Newell, Kavitha A. Kolla, and Veronique Weinstein
Cancer Type and Risk of Newly Diagnosed Depression Among Elderly Medicare Beneficiaries With Incident Breast, Colorectal, and Prostate Cancers
Monira Alwhaibi, Usha Sambamoorthi, Suresh Madhavan, Thomas Bias, Kimberly Kelly, and James Walkup
depression; specifically, that 10% to 25% of breast cancer survivors, 5 , 7 , 8 8% to 18% of colorectal cancer (CRC) survivors, 9 , 10 and 5% to 10% of prostate cancer survivors will experience depression. 11 , 12 Variability in the prevalence rates of
Change Toward Healthier Lifestyles Is Associated With Better Health-Related Quality of Life in Long-Term Colorectal Cancer Survivors
Ruth Elisa Eyl-Armbruster, Melissa S.Y. Thong, Prudence R. Carr, Lina Jansen, Jenny Chang-Claude, Michael Hoffmeister, Hermann Brenner, and Volker Arndt
and treatment, and aging of the population. 2 In Western countries, CRC survivors represent the third largest survivor group after breast and prostate cancer survivors. 1 Many CRC survivors still experience detriments in health-related quality of
Models of Care and NCCN Guideline Adherence in Very-Low-Risk Prostate Cancer
Ayal A. Aizer, Jonathan J. Paly, Anthony L. Zietman, Paul L. Nguyen, Clair J. Beard, Sandhya K. Rao, Irving D. Kaplan, Andrzej Niemierko, Michelle S. Hirsch, Chin-Lee Wu, Aria F. Olumi, M. Dror Michaelson, Anthony V. D’Amico, and Jason A. Efstathiou
Kenfield SA . Watchful waiting and quality of life among prostate cancer survivors in the physicians’ health study . J Urol 2011 ; 186 : 1862 – 1867 . 6. Eldefrawy A Katkoori D Abramowitz M . Active surveillance vs. treatment for low
Survivorship: Sexual Dysfunction (Male), Version 1.2013
Crystal S. Denlinger, Robert W. Carlson, Madhuri Are, K. Scott Baker, Elizabeth Davis, Stephen B. Edge, Debra L. Friedman, Mindy Goldman, Lee Jones, Allison King, Elizabeth Kvale, Terry S. Langbaum, Jennifer A. Ligibel, Mary S. McCabe, Kevin T. McVary, Michelle Melisko, Jose G. Montoya, Kathi Mooney, Mary Ann Morgan, Tracey O’Connor, Electra D. Paskett, Muhammad Raza, Karen L. Syrjala, Susan G. Urba, Mark T. Wakabayashi, Phyllis Zee, Nicole McMillian, and Deborah Freedman-Cass
cancer has been reported to range from 45% to 75%, 2 , 16 , 17 and it has been reported in up to 90% of prostate cancer survivors. 18 - 22 NCCN Clinical Practice Guidelines in Oncology : Survivorship: Sexual Dysfunction (Male), Version 1
The Internet as a Route to Health Information, Support, and Healthcare for Cancer Survivors
Jacqueline L. Bender
use based on sociodemographic factors. 14 , 16 In contrast, in a population-based study of prostate cancer survivors in Canada, age, education, and income did not play a significant role in determining health-related Internet use when other factors
A Method for Using Life Tables to Estimate Lifetime Risk for Prostate Cancer Death
Hyung L. Kim, Marvin R. Puymon, Maochun Qin, Khurshid Guru, and James L. Mohler
. Quality of life and satisfaction with outcome among prostate-cancer survivors . N Engl J Med 2008 ; 358 : 1250 – 1261 . 5. Partin AW Mangold LA Lamm DM . Contemporary update of prostate cancer staging nomograms (Partin Tables) for the new
Outcomes of a Dietary Intervention to Reduce Bladder Cancer Recurrence and Progression in Survivors of Non–Muscle-Invasive Bladder Cancer
Karen H. Kim Yeary, Han Yu, Margaret Gates Kuliszewski, Qiang Li, Susan E. McCann, Rachel Pratt, Frances G. Saad-Harfouche, Zinian Wang, Nikia Clark, Chong Wang, Elizabeth DiCarlo, and Li Tang
review of prospective studies reported associations between various measures of diet (eg, diet quality, adherence to Mediterranean diet) and improved cancer outcomes in breast, colorectal, and prostate cancer survivors. 28 The discrepancy in diet
Impact of a Clinical Trial Initiative on Clinical Trial Enrollment in a Multidisciplinary Prostate Cancer Clinic
Lydia T. Madsen, Deborah A. Kuban, Seungtaek Choi, John W. Davis, Jeri Kim, Andrew K. Lee, Delora Domain, Larry Levy, Louis L. Pisters, Curtis A. Pettaway, John F. Ward, Christopher Logothetis, and Karen E. Hoffman
patient population. Prostate cancer remains the second leading cause of cancer-related death among men in the United States, and prostate cancer survivors frequently experience long-term side effects of treatment. 2 , 3 An obstacle to research progress is
The Role of Active Surveillance in the Management of Prostate Cancer
Simon D. Fung-Kee-Fung, Sima P. Porten, Maxwell V. Meng, and Michael Kuettel
Michalski J . Quality of life and satisfaction with outcome among prostate-cancer survivors . N Engl J Med 2008 ; 358 : 1250 – 1261 . 15 Pardo Y Guedea F Aguilo F . Quality-of-life impact of primary treatments for localized prostate cancer in
