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Neutrophil Biology and the Next Generation of Myeloid Growth Factors

David C. Dale

References 1 Dale DC . Nonmalignant disorders of leukocytes . In: Dale DC Federman DD , eds. ACP Medicine 2006. New York : WebMD, Inc. ; 2006 : 1030 – 1037 . 2 Dale DC Boxer LA Liles WC . The phagocytes: neutrophils

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JAK2 R683S Mutation Resulting in Dual Diagnoses of Chronic Eosinophilic Leukemia and Myelodysplastic/Myeloproliferative Overlap Syndrome

Nathan M. Krah, Laura Miotke, Peng Li, Jay L. Patel, Anneli R. Bowen, Anthony D. Pomicter, and Ami B. Patel

by rigors and an erythematous nonpruritic diffuse morbilliform rash involving his trunk, arms, and legs. A skin biopsy was performed and showed acute eosinophilic spongiosis with focal intraepithelial neutrophils ( Figure 1E, F ). An extensive

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BIO22-031: Potential Implications in Immunotherapy and Prognostic Outcomes of Non-Small Cell Lung Cancer for Computational Recognition of lncRNA Signature of Tumor-Associated Neutrophils

Zhuoran Tang, Chunyu Li, Peixin Chen, Haoyue Guo, Jinpeng Shi, Yingying Pan, Qi Wang, and Caicun Zhou

Long noncoding RNAs (lncRNAs) are correlated with the regulation of tumor microenvironment (TME) and cancer immunity. Nevertheless, the role of lncRNAs in tumor-associated neutrophils (TANs) has yet to be established. Here, a computing framework

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Adherence to Hematologic Hold Parameters in Carboplatin and Dose-Dense Paclitaxel Chemotherapy for Ovarian Malignancies: A Survey of NCCN Member Institutions

Marina Stasenko, R. Kevin Reynolds, Carolyn Johnston, Melissa Brackman, Karen McLean, and Shitanshu Uppal

-0262 used hematologic hold parameters that were lower than the conventional regimen hold parameters. Chemotherapy day 1 absolute neutrophil count (ANC) hold parameters were decreased to 1.0 × 10 9 cells/L from conventional levels of 1.5 × 10 9 cells

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CGE23-070: Baseline Neutrophil to Lymphocyte Ratio and Its Change Over Time Predict Overall Survival in Metastatic Non–Small Cell Lung Cancer Patients Who Received First Line Pembrolizumab Therapy

Kenneth Chian, Mingjia Li, Songzhu Zhao, Saira Farid, Timothy Gauntner, Daniel Spakowicz, Lai Wei, Austin Secor, Evelyn Goodyear, Parthib Das, Kai He, Asrar Alahmadi, Regan Memmott, Jacob Kaufman, Carolyn Presley, Peter Shields, David Carbone, Greg Otterson, and Dwight Owen

Background: Neutrophil to lymphocyte ratio (NLR) predicts overall survival (OS) in cancer patients (pts) treated with immune checkpoint inhibitors (ICI). Historically, most studies included heterogenous populations and had limited data beyond

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Cutting Edge: Flow Cytometry in Myelodysplastic Syndromes

Arjan A. van de Loosdrecht and Theresia M. Westers

45 expression on myeloid progenitor cells compared with that of reference lymphocytes (≤4.0 or ≥7.5) A decreased sideward light scatter (SSC) of neutrophils compared with that of reference lymphocytes (≤6.0) Displayed reference ranges were

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Impact of Recombinant Granulocyte Colony-Stimulating Factor During Neoadjuvant Therapy on Outcomes of Resected Pancreatic Cancer

Pranav Murthy, Mazen S. Zenati, Samer S. AlMasri, Annissa DeSilva, Aatur D. Singhi, Alessandro Paniccia, Kenneth K. Lee, Richard L. Simmons, Nathan Bahary, Michael T. Lotze, and Amer H. Zureikat

Background Neutropenia is a common adverse event associated with chemotherapy. Recombinant granulocyte colony-stimulating factor (G-CSF) boosts granulopoiesis and neutrophil maturation 1 , 2 and is approved by the FDA for patients with

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Unusual Adverse Events in a Patient With BRAF-Mutated Non–Small Cell Lung Cancer Treated With BRAF/MEK Inhibition

Rohan Maniar, Stephanie M. Gallitano, Sameera Husain, Golnaz Moazami, Michael J. Weiss, and Catherine A. Shu

upper extremity. The lesions were intermittent and occasionally accompanied by low-grade fevers. A skin biopsy of the thigh revealed mild perivascular and subcutaneous infiltrate of lymphocytes and few neutrophils consistent with neutrophilic dermatosis

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Long-Term Outcomes of Myeloid Growth Factor Treatment

Gary H. Lyman and David C. Dale

have blood neutrophil counts that are chronically or intermittently less than 0.5 × 10 9 /L for several years or their lifetime. SCN can be inherited or acquired and is usually categorized as cyclic, congenital, or idiopathic based on clinical and

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Advances in Personalized Therapeutic Approaches in Myelodysplastic Syndromes

Rafael Bejar

-risk disease ( Figure 1 ). Figure 1. Revised IPSS-R. Abbreviations: ANC, absolute neutrophil count; AML, acute myeloid leukemia; IPSS-R, Revised International Prognostic Scoring System. Adapted from Schanz J, Tüchler H, Solé F, et al. New comprehensive