Merkel cell polyomavirus (MCV) is detected in 43% to 100% of patient samples. 10 The role of MCV in the pathogenesis of MCC is under active investigation. 11 The NCCN Non-Melanoma Skin Cancer Panel has developed guidelines outlining treatment of MCC to
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Christopher K. Bichakjian, Thomas Olencki, Murad Alam, James S. Andersen, Daniel Berg, Glen M. Bowen, Richard T. Cheney, Gregory A. Daniels, L. Frank Glass, Roy C. Grekin, Kenneth Grossman, Alan L. Ho, Karl D. Lewis, Daniel D. Lydiatt, William H. Morrison, Kishwer S. Nehal, Kelly C. Nelson, Paul Nghiem, Clifford S. Perlis, Ashok R. Shaha, Wade L. Thorstad, Malika Tuli, Marshall M. Urist, Timothy S. Wang, Andrew E. Werchniak, Sandra L. Wong, John A. Zic, Karin G. Hoffmann, Nicole R. McMillian, and Maria Ho
Christopher K. Bichakjian, Thomas Olencki, Sumaira Z. Aasi, Murad Alam, James S. Andersen, Rachel Blitzblau, Glen M. Bowen, Carlo M. Contreras, Gregory A. Daniels, Roy Decker, Jeffrey M. Farma, Kris Fisher, Brian Gastman, Karthik Ghosh, Roy C. Grekin, Kenneth Grossman, Alan L. Ho, Karl D. Lewis, Manisha Loss, Daniel D. Lydiatt, Jane Messina, Kishwer S. Nehal, Paul Nghiem, Igor Puzanov, Chrysalyne D. Schmults, Ashok R. Shaha, Valencia Thomas, Yaohui G. Xu, John A. Zic, Karin G. Hoffmann, and Anita M. Engh
Merkel cell carcinoma (MCC) is a cutaneous neuroendocrine neoplasia formerly called trabecular carcinoma . Although rare, with approximately 2,488 cases per year diagnosed in the United States, 1 MCC is one of the most aggressive skin cancers, and its
Ata S. Moshiri and Paul Nghiem
Merkel cell carcinoma (MCC), or primary neuroendocrine carcinoma of the skin, is an aggressive cutaneous malignancy with 3 times the disease-specific mortality of melanoma (46% vs 15%). 1 The annual incidence is approximately 1500 cases in the
Roy H. Decker and Lynn D. Wilson
treatment of Merkel cell carcinoma: case series and literature review of 1024 cases . Ann Surg Oncol 2001 ; 8 : 204 – 208 . 2. Gillenwater AM Hessel AC Morrison WH . Merkel cell carcinoma of the head and neck: effect of surgical excision and
Jennifer L. Schwartz, Sandra L. Wong, Scott A. McLean, James A. Hayman, Christopher D. Lao, Jeffrey H. Kozlow, Kelly M. Malloy, Carol R. Bradford, Marcus L. Frohm, Douglas R. Fullen, Lori Lowe, and Christopher K. Bichakjian
Merkel cell carcinoma (MCC), diagnosed primarily in the elderly white population, is an uncommon, clinically aggressive cutaneous malignancy with a high rate of local, regional, and distant recurrence. During the last 2 decades of the 20th century
Vishwajith Sridharan, Vinayak Muralidhar, Danielle N. Margalit, Roy B. Tishler, James A. DeCaprio, Manisha Thakuria, Guilherme Rabinowits, and Jonathan D. Schoenfeld
Background Merkel cell carcinoma (MCC) is a rare, cutaneous neuroendocrine cancer with an aggressive natural history. Epidemiologic studies indicate that MCC affects approximately 2.3 individuals per million, with incidence in the United
Michael D. Green and James A. Hayman
Merkel cell carcinoma (MCC) is a relatively rare cutaneous malignancy, predominantly diagnosed in elderly individuals (aged >70 years), that is increasing in incidence as the population ages. 1 Due to the rarity of this disease, there is a
Stanley J. Miller, Murad Alam, James Andersen, Daniel Berg, Christopher K. Bichakjian, Glen Bowen, Richard T. Cheney, L. Frank Glass, Roy C. Grekin, Dennis E. Hallahan, Anne Kessinger, Nancy Y. Lee, Nanette Liegeois, Daniel D. Lydiatt, Jeff Michalski, William H. Morrison, Kishwer S. Nehal, Kelly C. Nelson, Paul Nghiem, Thomas Olencki, Allan R. Oseroff, Clifford S. Perlis, E. William Rosenberg, Ashok R. Shaha, Marshall M. Urist, and Linda C. Wang
the express written permission of the NCCN © 2009. Disclosures for the NCCN Merkel Cell Carcinoma Guidelines Panel At the beginning of each NCCN guidelines panel meeting, panel members disclosed any financial support they have received from
Kelly G. Paulson and Shailender Bhatia
Merkel Cell Carcinoma Presentation and Incidence Merkel cell carcinoma (MCC) typically presents as a rapidly enlarging red nodule on sun-exposed skin. 1 Risk factors include UV radiation exposure, age >65 years, and infection with the Merkel
Samuel W. Beenken and Marshall M. Urist
treatment of Merkel cell carcinoma: case series and literature review of 1024 cases . Ann Surg Oncol 1997 ; 8 : 204 – 208 . 3 Kokoska ER KoKoska MS Collins BT . Early aggressive treatment for Merkel cell carcinoma improves outcome . Am J Surg
