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Wen-Zhuo He, Wan-Ming Hu, Fang Wang, Yu-Ming Rong, Lin Yang, Qian-Kun Xie, Yuan-Zhong Yang, Chang Jiang, Hui-Juan Qiu, Jia-Bin Lu, Bei Zhang, Pei-Rong Ding, Xiao-Jun Xia, Jian-Yong Shao and Liang-Ping Xia

cancer alone. 3 The mismatch repair (MMR)/microsatellite instability (MSI) pathway significantly contributes to CRC development 12 , 13 and is associated with the immune microenvironment. 14 , 15 However, although the distinct features of MSI-high (MSI

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Michael J. Hall

appropriately. Traditionally, family history was the primary way to identify individuals with Lynch. 2 – 5 When guided by family history–based criteria, 2 , 3 2 tumor-based screening tests (microsatellite instability [MSI] and immunohistochemical [IHC

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Nabil El-Hadi Omar, Sahar Nasser, Mahmoud Gasim, Maneesh Khanna, Abdulqadir J. Nashwan, Jonas W. Feilchenfeldt, Kakil Rasul and Anas Hamad

Background: Microsatellite instability-high (MSI-H) is shown to predict response to the immune checkpoint inhibitors (ICPi). Recently, the FDA granted an accelerated approval for the use of pembrolizumab in any solid tumor and nivolumab in

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Vivek Subbiah and Kanishka Sircar

surrogate for tumor mutational burden (TMB), and the presence of an inactivating MLH1 alteration (a marker for mismatch repair deficiency [dMMR]/microsatellite instability-high [MSI-H] tumor). Despite the patient’s PTCH1 mutation, the tumor did not

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Christina Rybak and Michael J. Hall

The characteristic phenotype of LS tumors is microsatellite instability (MSI), a sign of defective MMR. 17 , 18 Microsatellites are areas of the genome at which the DNA sequence is repetitive (e.g., (CA) n ). During DNA replication, errors may occur

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Isabelle Bairati, Anne-Sophie Julien and Jocelyne Chiquette

Background: To evaluate the quality of an organized mammography screening program based on the perception of screened women, we developed and validated the French-language Mammography Satisfaction Instrument (MSI). The study objective was to

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Katherine Van Loon and Alan P. Venook

seem surprising, it is actually consistent with the fact that a greater proportion of tumors with high-level microsatellite instability (MSI) exhibit poorly differentiated histology. 22 , 23 Patients with MSI-high tumors, leading to defective DNA

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Wells A. Messersmith

Guidelines for unresectable stage IV metastatic CRC. This update applies only to patients with KRAS/NRAS/BRAF wild-type and left-sided tumors. Microsatellite Instability/Mismatch Repair Microsatellite instability (MSI) and deficient mismatch repair (dMMR

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Sean Dineen, Patrick M. Lynch, Miguel A. Rodriguez-Bigas, Sarah Bannon, Melissa Taggart, Colleen Reeves, Cathy Modaro, Michael Overman, George J. Chang, John M. Skibber and Y. Nancy You

phenotype recognition. Indeed, LS-associated CRC exhibits a distinct molecular signature: DNA mismatch repair deficiency (dMMR). dMMR can be reliably detected by immunohistochemical studies (IHC) and microsatellite instability assays (MSI) performed on CRC

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Michael S. Lee, David G. Menter and Scott Kopetz

aneuploidy. 40 , 41 CIMP-high CRCs are particularly enriched in tumors with microsatellite instability (MSI)–high due to epigenetic Table 1. Molecular Features of Preneoplastic Lesions and CRC by Site silencing of the MLH1 mismatch repair