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Maxim Norkin and John R. Wingard

Because of prolonged neutropenia and severe immunosuppression, patients with hematologic malignancies (HMs) and hematopoietic stem cell transplant (HSCT) recipients are at high risk for invasive fungal infections (IFIs), which are associated with

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Thomas A. Cumbo and Brahm H. Segal

Severe Candidal Infections [see comments] . Clin Infect Dis 1997 ; 25 : 43 – 59 . 6 Viscoli C Girmenia C Marinus A . Candidemia in cancer patients: a prospective, multicenter surveillance study by the Invasive Fungal Infection Group (IFIG

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Antonio V. Gonzalez, Andrew J. Ullmann, Nikolaos G. Almyroudis and Brahm H. Segal

Pfizer. References 1. Ascioglu S Rex JH de Pauw B . Defining opportunistic invasive fungal infections in immunocompromised patients with cancer and hematopoietic stem cell transplants: an international consensus . Clin Infect Dis 2002

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Johan Maertens, Kristel Buvé and Elias Anaissie

randomized-controlled clinical trials . Cancer 2002 ; 94 : 3230 – 3246 . 5. Glasmacher A Prentice A Gorschluter M . Itraconazole prevents invasive fungal infections in neutropenic patients treated for hematologic malignancies: evidence from a

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Hematological Malignancies Kleinberg Michael MD, PhD 9 2004 2 2 5 5 445 445 451 451 10.6004/jnccn.2004.0035 Prevention, Diagnosis, and Treatment of Invasive Fungal Infections in Patients with Cancer and Neutropenia Cumbo Thomas A. MD Segal

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Buscariollo Daniela L. b MD Gross Cary P. c MD Makarov Danil V. d MD, MHS Yu James B. a MD 08 2013 11 11 8 8 928 928 936 936 0110928 10.6004/jnccn.2013.0114 Diagnostic Strategies for Invasive Fungal Infections in Patients With

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Lindsey Robert Baden, Sankar Swaminathan, Michael Angarone, Gayle Blouin, Bernard C. Camins, Corey Casper, Brenda Cooper, Erik R. Dubberke, Ashley Morris Engemann, Alison G. Freifeld, John N. Greene, James I. Ito, Daniel R. Kaul, Mark E. Lustberg, Jose G. Montoya, Ken Rolston, Gowri Satyanarayana, Brahm Segal, Susan K. Seo, Shmuel Shoham, Randy Taplitz, Jeffrey Topal, John W. Wilson, Karin G. Hoffmann and Courtney Smith

–induced gastrointestinal tract GVHD. 21 Other studies of nontransplant patients with acute leukemia showed no significant benefit of fluconazole in preventing invasive fungal infections, reducing mortality, or reducing the requirement for amphotericin B. 22 , 23

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Lindsey Robert Baden, William Bensinger, Michael Angarone, Corey Casper, Erik R. Dubberke, Alison G. Freifeld, Ramiro Garzon, John N. Greene, John P. Greer, James I. Ito, Judith E. Karp, Daniel R. Kaul, Earl King, Emily Mackler, Kieren A. Marr, Jose G. Montoya, Ashley Morris-Engemann, Peter G. Pappas, Ken Rolston, Brahm Segal, Susan K. Seo, Sankar Swaminathan, Maoko Naganuma and Dorothy A. Shead

invasive fungal infections, reducing mortality, or reducing the requirement for amphotericin B. 101 , 102 The panel recognizes that strong evidence exists for the use of fluconazole as prophylaxis in neutropenic allogeneic HSCT recipients (category 1). 22

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Sophia Koo and Lindsey R. Baden

. Marty FM Lee SJ Fahey MM . Infliximab use in patients with severe graft-versus-host disease and other emerging risk factors of non-Candida invasive fungal infections in allogeneic hematopoietic stem cell transplant recipients: a cohort study . Blood

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Jacqueline N. Poston and Pamela S. Becker

incidence of bacteremia and invasive fungal infections. Furthermore, there was a marginal increase in adverse events with growth factors, leading to discontinuation of CSFs, compared with the control arm (RR, 1.33; 95% CI, 1.00–1.56). One pediatric trial