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Shilpa Grover and Sapna Syngal

-degree relative has CRC or a first-degree relative has a colorectal adenoma. 4 , 5 Among CRC cases, 3% to 5% are caused by highly penetrant inherited syndromes, including Lynch syndrome or hereditary nonpolyposis colorectal cancer (HNPCC), familial adenomatous

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Christina Rybak and Michael J. Hall

DNA mismatch repair . Cancer Res 2003 ; 63 : 5209 – 5212 . 36 Domingo E Laiho P Ollikainen M . BRAF screening as a low-cost effective strategy for simplifying HNPCC genetic testing . J Med Genet 2004 ; 41 : 664 – 668 . 37

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Randall W. Burt, James S. Barthel, Kelli Bullard Dunn, Donald S. David, Ernesto Drelichman, James M. Ford, Francis M. Giardiello, Stephen B. Gruber, Amy L. Halverson, Stanley R. Hamilton, Mohammad K. Ismail, Kory Jasperson, Audrey J. Lazenby, Patrick M. Lynch, Edward W. Martin Jr., Robert J. Mayer, Reid M. Ness, Dawn Provenzale, M. Sambasiva Rao, Moshe Shike, Gideon Steinbach, Jonathan P. Terdiman and David Weinberg

with a positive family history of CRC or advanced adenomas are considered at increased risk for developing CRC. High-Risk Syndromes Individuals with family history of Lynch syndrome (also known as hereditary nonpolyposis colorectal cancer [HNPCC

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Stephen B. Gruber and Wendy Kohlmann

Collaborative Group on Hereditary NonPolyposis Colorectal Cancer (ICG-HNPCC) . Dis Colon Rectum 1991 ; 34 : 424 – 425 . 5 Vasen HF Watson P Mecklin JP Lynch HT . New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch

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Patrick M. Lynch

performance of genetic counselor–driven germline mutation testing, in patients with hereditary nonpolyposis colorectal cancer (HNPCC)–related tumors, also known as Lynch syndrome. Suitably aggressive colorectal neoplasm surveillance is shown to be critical

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Brandie Heald, Shanna Gustafson, Jessica Mester, Patricia Arscott, Katherine Lynch, Jessica Moline and Charis Eng

breast-ovarian cancer syndrome; HNPCC, hereditary nonpolyposis colorectal cancer; PHTS, PTEN hamartoma tumor syndrome. Table 2 Average Time Spent on Activities for Each Encounter Discussion Traditional cancer genetics services

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Patrick M. Lynch

of 24 kindreds in the Netherlands . Int J Cancer 1990 ; 46 : 31 – 34 . 43. Aarnio M Mecklin JP Aaltonen LA . Life-time risk of different cancers in hereditary non-polyposis colorectal cancer (HNPCC) syndrome . Int J Cancer 1995 ; 64

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Patrick M. Lynch

guidelines, visit NCCN.org ). 1 These patients include the 2 broad categories of patients with familial adenomatous polyposis (FAP) and its variants, and those with hereditary nonpolyposis CRC (HNPCC), otherwise known as Lynch syndrome (LS). This commentary

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Joleen M. Hubbard and Axel Grothey

, Crohn disease, and regional enteritis), familial adenomatous polyposis (FAP), or hereditary nonpolyposis colorectal cancer (HNPCC) syndrome, and 22% had family history of CRC. 6 The 2 major known familial syndromes associated with CRC in young adults

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Wells A. Messersmith

) are typically acquired, rather than inherited, such as in cases of hereditary nonpolyposis CRC (HNPCC) or Lynch syndrome. According to Dr. Messersmith, it is important to recognize the relationship between BRAF mutations and MSI: the presence of a